HsaINT0089854 @ hg19
Intron Retention
Gene
ENSG00000115919 | KYNU
Description
kynureninase [Source:HGNC Symbol;Acc:6469]
Coordinates
chr2:143743517-143746473:+
Coord C1 exon
chr2:143743517-143743590
Coord A exon
chr2:143743591-143746413
Coord C2 exon
chr2:143746414-143746473
Length
2823 bp
Sequences
Splice sites
5' ss Seq
TGCGTGAGT
5' ss Score
7.55
3' ss Seq
TTGTACTTCATTTGCATTAGGAG
3' ss Score
5.48
Exon sequences
Seq C1 exon
TATTTAAATGCAGGAGCAGGAGGAATTGCTGGTGCCTTCATTCATGAAAAGCATGCCCATACGATTAAACCTGC
Seq A exon
GTGAGTACCATCTTCAGCTAATTCTTTGGTGATGAACAAATTAATTTGCATTAATAATATGTTAAATTTACATGAGTTCCTTAAGATGCTATCCAATAGGAATTAGGATTGGATTATAATTATTTTCCTACTCTGCTAACAACAATATACTTCATTTGAAATACATGCTTTCCAAAGAATTCAATTGGTTGAACAAGAAATTTAATCAAAAAGGGAAGCTTCAGTGCTAAAAACAAGTCACTGCAATCATGTAAAGCGGATGGTTTAATGCAAAGAGACCACTTGAATATTTTTTTTCAAAAATTAGACTTTAGAAAATTTCAGATTCCTCACGTTGATGAATAAATCAAAGGCAACCAGAGCTGTGCCTAATAGAGCCTTAAATGTGGCATGTTATTATTAAAATTACATCTACCTTTAAAGCTGTAAATGTTACATGATAGCTTGTAGGGAATATCTTCTGTCCTAAAAGACTTTATAATCCATGAAACCCGAAGAAGCTGAACACTGAACAACAGACTGACTACATAAAAAGTAATACTTTTCTGTTTTATAGAACTCTTCATATTTTAGAGCAAGTATAAATGCAAATATAATACACCAACAAACTTACACATTTTTATTTGACTGGGGAATTCATAAGTGTTCCTTTTACTTTTTTCTGGTATGGAAATAAAGAAATAATATGCTGGGAAGAAAAAAAAAAACCCTTTTCATAGTTGTTGTATTGGAGTATGTGTGGTGAGGAGACTGTCTAGACTCCTAATAGATAATGTAATAATGTTTGATTAGTTTTCTGAATTTCCTCAGCCACTGACTGAGTGGTAAAATCTTTACAAGAATTGAAGCTGAATTAGTAATAGGCTTTGGAGCACCTCACATTTCTGAAGTTCTGTGCATATAAATCCTAGGAATTTAAGATGATTTTCTATAGTTTCTTTAATTGTGTCTAAATTTTTTTCAAGGTTTTAAGGTTTTAAACTTAAGACAACATTTGTCTTAAGTTTAAATATCTTTGGACAGATATTTAGTCAACCAGACATCTTACTTGAATATCATTATCAGTACATTAGATTTCCCTCCATGTATGTCCCAACATCTCTGAGAAGATTAAAAAGCAAATATTATAAGAATACCATGTTTTCCACATAGACAGTATGTAAGATATTGCTTGCTTTTGTATGATGACTCACAACCCTGGCCATTTCTCAGTCTCCATTTATTTAAATTGAAATAGAGGATCTCATGTATTATATCAACCCAAAGGGTGAGCCAGTGCCCGGATAGAAGGAGGTGGGGTGGGGGGGAAGAAGTAATATACATAAATTCTAGAGAATGTCAGTGTTCGGAGTTAAGCTTTGACCTCCTAGCACACACAGGTCTTGTACTTGAGATTTCTCTCAGCATGGACAAGGAACAAGGACAAAGGGATTGTATTGTGCTCACATATGCCTCATTTTGTGGAATTTCAAAATCTTCTAGACAATGTTTAAATCTATGTTAAGTCTAAGCTCCCAAGAGAAAGACCATCTAGGCAGACCAGGTTCACAGTTCAGCTTGGTCTTTCAGGGGTCTGTCACCTGGAGAATCTTCTATGATTGTTCAGTATTCTGGTCTCTGAGCTGAGGTAGTACCAGCCCCTACTCATAAGCAGTTATTGTGAGAATAAAATGAGATGATGTATGTAAAACACTAAGTGTATCACTTGAACATTTAATATGGTTTGGATTTGTGTCCCCACCCAAATCTCATGTAGAATTGTAATCCCCAGTGTTGGAGCAGGGGCCTGGTGGGAGGTGATGGGACAATGGGGCCTTTCCCTTTGCTATTCTCATGATGGTGAGTTCTTAATGAAATATAGTTGTTTAAAAGTGTGTAGCACCTTCTCCTTCTCTCTCTTCCTCCTGCTCTGGCCATGAAAGATGTTCCTGCCTCCCCCTTCACCCTCTGCCATGGTTGTAAGTTTCCTGAGGCCTTCCCAGTCATGCTTCCTGCACAGCCTGCAAAACCATGAACAAATTAAACCTCTTTTCTTTATAAATTACCCAGTCTCAGGCAGTTGTTTGTAGCAGTGAGAGAATGGACTAATACAGCATTATATGTGATCAATAGGTATGGGGTTATATGAAAAAAAAAATCCAAAATTTACAATATACAGGAAAAAGATGGGTGACATTCTGTAACACCCTAGCCCAAGTATTGTTTGGTAATTATTTAGTACTGACCCCTAAGTACTTCGTTGACTCACTGAGAATGTGCATAGTAACATGTAGACTTTGCCCAGTGGAGATCATTTCTCTTAAGCAGAAAATATAACCTCAAAGTTTATGGTTTGTGACTTTGTAGGACATTAGTTTGTAACTATCACCAAGTTTATTTTAGCAGACCTTTGATGAGCTGACTGTAGAATATAATCTCCATTCCTTGGAGATATAATCTCTCTTATATGCTATAAGAAAGAATTCTGGCCTTCCTACCATCTTACTGATTCCGCCACTATTTAGTGGGTTGAATGAGATCTTTCATGGCTGTTTATTTTGTGTGTGTATGAGAACCTTGCTTTTAAGTTTTTTGGAAAATTATATGTTATTAGCTGTTGTTGCATTTTAACAATTTAGCCATGGAAATTTATGGGACTTAAATTAGGCTTGACTCATGAAGGCCACGTTAAGGAAAACCTTGGTTGTTTTTCTGTTTATTGTTTTCTCACACTCCTAAGCTTCTTTTTAAGTGATGTCAGTGACTGATCTCAGTGCTGTCAACTTCTAGCCTTGGCTCTCTATTCTGTACCAAGTATCTTATATTGTACTTCATTTGCATTAG
Seq C2 exon
GAGATCGGAGTTCTTTAATTAGGAATGGAATGCAACAGATTTGGACAAGTCAAGGACAAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSG00000115919-KYNU:NM_001032998:10
Average complexity
IR-C
Mappability confidence:
NA
Protein Impact
ORF disruption upon sequence inclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.000 A=NA C2=0.000
Domain overlap (PFAM):
C1:
PF0026614=Aminotran_5=FE(10.2=100)
A:
NA
C2:
PF0026614=Aminotran_5=PD(1.3=37.5)
Main Inclusion Isoform:
NA
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
NA
Associated events
Other assemblies
Conservation
Zebrafish
(danRer10)
No conservation detected
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
No suggested primer sequences
R:
No suggested primer sequences
Band lengths:
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Genotype-Tissue Expression Project (GTEx)
- Autistic and control brains
- Pre-implantation embryo development
Other AS DBs:
FasterDB (Includes CLIP-seq data)
AS-ALPS (AS-induced ALteration of Protein Structure, links to PINs)
APPRIS (Selection of principal isoform)
DEU primates (Only for human)