HsaINT0146230 @ hg38
Intron Retention
Gene
ENSG00000146197 | SCUBE3
Description
signal peptide, CUB domain and EGF like domain containing 3 [Source:HGNC Symbol;Acc:HGNC:13655]
Coordinates
chr6:35228614-35231859:+
Coord C1 exon
chr6:35228614-35228739
Coord A exon
chr6:35228740-35231724
Coord C2 exon
chr6:35231725-35231859
Length
2985 bp
Sequences
Splice sites
5' ss Seq
TGGGTAAGC
5' ss Score
8.84
3' ss Seq
TGACTACCTATCCTGCACAGATG
3' ss Score
7.18
Exon sequences
Seq C1 exon
ACGTGGATGAGTGCGAGCGAGAGGATAATGCAGGTTGTGTGCATGACTGTGTCAACATCCCTGGCAATTACCGGTGTACCTGCTATGATGGATTCCACCTGGCACATGACGGACACAACTGTCTGG
Seq A exon
GTAAGCAAAGGAGAGGGGATTTGGTGGAGGGATGTCTTGTGGAGAAAGAGATCTTTTCAGCATTTCCTATTTCCCAGGGAAGGAGGAGAGAGTGATCAAGAAGAGCTACATTCACAAGAGAATAAGGTCAGCCTCCCCTTTGAGACTGGCCACTTAGGATGAAAAATCCTGCTGGATGAAAAACATTAGAGGAAAAGCTGCTACGAAATGCTCCTAGGGCAAGGGCCAGGAGATGGGAATAGTGGGTTTAGCCAGTGGTGAGGCATGGTAGGAAGCTGATTTGGCTCCACACAGATATCTTGGTTCTGCTGCTTACTAGCCTTGGGTCTTGGGCAAATCAGCCAATCTCTGGAAATCTCATCTTTCTCCTCTCTAAAATGGGGGTGGGACCAGGTGTGGTAGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGAGGGACTGCTAGAGCCCAGGAGTTCAAGACAGGCCTGGGCAACATAGTGAGACCCTGTTTCTACAAAAAATAATAATAATAAAAATTAGTCAGTCATGATGGTGCATACCTGTAGTCCCCAGCTACTTGGGAGCTCTTCCTTGGCTTGAGCCTAGGAAGTCGAGGCTGCAGTTAGCTGTGATTGTGTCACTGCGCTCCAGATCGAGCAATCTTATCTCAAAAAATAACAATAAAATAGAATGGGGTGGTAATAACCCACTTGAAGGCTGCTGTGCGGATCACCACAAGACAACATATGAAAAGAGCCCTGTACAATCCTTAGCACATGGTAGGAGCTCAGTAATGGGAAGAATGTTTTTGATGATGACGACAGTGCATCCCTATGCCCCAGGAAGCCTCTGACCCTTACAGGCTTGTTTTCTCCCAGTTCTTCCTGCAATCTCCAGTCTCACCCTCTCCTCACTGATCTCCTTTGTCCCAGGAGCTGGATCAGAGATAAGAGAATCTCTAAGGAACTGAACTCAACTTTGGTCTCTGTCATTTTGGAAAATTACTGGGACCAAGTCAGACTCTTCCCCAAGCAGAAAATCTGAAGCTCATAGCAGAAAAGGATTTGAAATTTGAACCCAGGGCCTTCTCCCAAATTACTTCACCCTGTAGCCACAACAGAAAACAGGCACTAGAAGCATAAAGGACCAGGAAAGGAAGAGAAACAAAAGGAATGATGCCCAGAAAAGCAGGCTGGGCTGGTCCTCACCCACCAATTGACCAAATAGATGAATTCTCTTAAGTCCTATTGGCTGAGAAGAGCCTCCTTACTGCAGAGCTGCCTCCAAACCTAGTCATAACCCATCATTGGACCCAGGCTATAGGTTTCTACACCCAACCCTGGCCTCCAAACCCTGATATCTGCTGGGCCCTTAATCCCAGCCCTGGTCACCTCTCCTACCATTTTAGCTTCCAGGGAAGGGCCTCATATCTGCCCAGTCACCCTTGAGGGCCTCTTATGAAACTCCTTTGGGAAGGGAAGCTGTGGCACTTAGACCAGGACAGTGAGTTGCCTACAGGACATGCACATAAGCTTCTGAGTTCTTTGGCTGCCTTTGACTTTTCTAGGCCCCTGATTGTCACCACATCTCATTTCCCTATAAGTGTTTTGGGGAGAACCAACCAGAGGGACAAGAGAATGATTAGGTATAGAGAGGGTCAAGGGACAAAGATTACCTAGGGTTAGGGTTCAAAGTCTCAATACTACCTTTGGCTCTTAGGGGAATTTTGAGAAAGTTGTCCATGCTCTGGGCCTTAGCTTCCCCACTGAGAATTGGAGGAAAGAGCTTGGCTAGAGTAGCAAAGCCACAAGGTTAGATAGTAAGGGAGCAGACAGAAGGATGGCATGTAGAATGTGGCAAGAGCAGGAAGACAGGGATGGGGAGAAGTCAAGAGAACAGCAAAAGACAGGGTAGAGACAGGAGCAAAGCACAGGAAAGTACACCTTAGCTCTTCCAACAGGTGCATCTCTTGGGCAAGAGCCAGCTGGATCTGGGCCTCTCTGCCCTGGCCAGAAGGGGAAGAGAAGGTTGCAGGATCTCAGCAGAGAGGATGGGAAGAGAGGGGCAGATGAAGCCCTCAGGAGCCCAGATTCTAGCTGCTCCATTTGACAACCAATCTACGTGATGCCTCCTGGGCCAAGGCAAACTGAGAAGGGCCATGGACTTGGGAGGGCAGTAGCTAGCATAGAGATGGAATCAAGGTGTTGAATTGGGGGCTCCAGGGTGAGCTTGGCTCTAGAACCTAGGGGTGGTGATTTGGGGGTGAGAGCCTACTGTTCTCCCTGCCCCCCACCCCCACCATCTAGGGTGTGGCCTGGCAGCTCTCCCCAGATCCCTCCCCGCCAAGTTGTCAGACTTTGTTTTGTTAAGCCAAAATAGGAGAAAGGCTAGGGAATATGGCAGCAAGCCCAGGCACAGGGGGGAGGGGAGGAAGGACAGGGCTGTGGCCTGTCCACAGAAATGGTCCCTGCTCCACAAGGAGGTGAGGCTCAGCTGCCTTTCCCCACCCTGCCCCTCCAACCTCAGCACCATGGCCATAGCTCTGCCTGCACCCAGAGCCACTTCCCAGGTTCCTACATTCCCTGGCTGCTCATTGCAACCAGCTGCAACCCCCAGTTACCTATCCGACCAATGTGACCAATCTCCATCCTTACCTTCATCACTGTTCCTCTTTCTCTGGCTTCTTTCCTGGTGTCCTCTGTCTTCATACCCAGTTTACACAGGTGAGGGAAAGGGAGGCATGGCTTCACCTAGGTGACATTTGAGGTTCAAAGGTCCCCTTTTCCCCCACTTGCTTAGCTTCCCAGCTCTGCCCTCAGGGCAGCCTTTTTACACTTAGTGAAATATTAGCTGACAAGGGTGTGAGGACTTCCTGGCTTAAGGCTGGGCTTAGGGGGTAGTAGTTCTTAAGACTGCCTTTGGTGCTGAAGTCTTGGGATATACCCTGGACCCTGCCTGTACCCCATGACCCCACTGACTACCTATCCTGCACAG
Seq C2 exon
ATGTGGACGAGTGTGCCGAGGGCAACGGCGGCTGTCAGCAGAGCTGTGTCAACATGATGGGCAGCTATGAGTGCCACTGCCGGGAAGGCTTCTTCCTCAGCGACAACCAGCATACCTGTATCCAGCGGCCAGAAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSG00000146197:ENST00000274938:3
Average complexity
IR
Mappability confidence:
NA
Protein Impact
ORF disruption upon sequence inclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.000 A=NA C2=0.050
Domain overlap (PFAM):
C1:
PF146701=FXa_inhibition=WD(100=86.0)
A:
NA
C2:
PF126622=cEGF=PD(12.5=6.5),PF146701=FXa_inhibition=WD(100=78.3)
Main Inclusion Isoform:
NA
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
NA
Associated events
Other assemblies
Conservation
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
No suggested primer sequences
R:
No suggested primer sequences
Band lengths:
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Genotype-Tissue Expression Project (GTEx)
- Autistic and control brains
- Pre-implantation embryo development