Special

MmuEX0014891 @ mm9

Exon Skipping

Gene
ENSMUSG00000030409 | Dmpk
Description
dystrophia myotonica-protein kinase [Source:MGI Symbol;Acc:MGI:94906]
Coordinates
chr7:19674260-19677193:+
Coord C1 exon
chr7:19674260-19674345
Coord A exon
chr7:19676278-19676389
Coord C2 exon
chr7:19677030-19677193
Length
112 bp
Sequences
Splice sites
3' ss Seq
TAGCCTCTTCCTCTTCTCAGAGA
3' ss Score
7.94
5' ss Seq
GTGGTGAGT
5' ss Score
8.95
Exon sequences
Seq C1 exon
GAGACGCTGTCAGACATGCAGGAAGACATGCCCCTTGGGGTGCGCCTGCCCTTCGTGGGCTACTCCTACTGCTGCATGGCCTTCAG
Seq A exon
AGACAATCAGGTCCCGGACCCCACCCCTATGGAACTAGAGGCCCTGCAGTTGCCTGTGTCAGACTTGCAAGGGCTTGACTTGCAGCCCCCAGTGTCCCCACCGGATCAAGTG
Seq C2 exon
GCTGAAGAGGCTGACCTAGTGGCTGTCCCTGCCCCTGTGGCTGAGGCAGAGACCACGGTAACGCTGCAGCAGCTCCAGGAAGCCCTGGAAGAAGAGGTTCTCACCCGGCAGAGCCTGAGCCGCGAGCTGGAGGCCATCCGGACCGCCAACCAGAACTTCTCCAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000030409_CASSETTE5
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact





	

	
ORF disruption upon sequence exclusion





No structure available

		

			
Features


			

				
Disorder rate (Iupred):
  C1=0.202 A=0.684 C2=0.745
 
                        

				
Domain overlap (PFAM):

					





						

							
C1:
NO

							
A:
PF104814=CENP-F_N=PU(21.9=55.3),PF041569=IncA=PU(26.2=84.2)

							
C2:
PF104814=CENP-F_N=FE(55.7=100),PF041569=IncA=FE(43.2=100),PF0003816=Filament=PU(57.1=80.0),PF088265=DMPK_coil=PU(50.8=56.4),PF139491=ALIX_LYPXL_bnd=PU(41.1=70.9)

						

					

				








    
Main Inclusion Isoform:
ENSMUSP00000032568





     
                   









    
Main Skipping Isoform:
ENSMUSP00000104111





     
      









    
Other Inclusion Isoforms:
ENSMUSP00000104112, ENSMUSP00000104113, ENSMUSP00000104114, ENSMUSP00000104115, ENSMUSP00000118459
          









    
Other Skipping Isoforms:
NA
  



Associated events







Other assemblies


mm10




Conservation


Human
(hg38)
chr19:45772641-45772752 
HIGH PSI
HsaEX6095707
(DMPK)
Human
(hg19)
chr19:46275899-46276010 
HIGH PSI
HsaEX6095707
(DMPK)
Rat
(rn6)
chr1:79996436-79996547 
HIGH PSI
RnoEX0028278
(Dmpk)
Cow
(bosTau6)
chr18:53762864-53762972 
HIGH PSI
BtaEX6083029
(DMPK)
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Fruitfly
(dm6)
No conservation detected




Primers PCR

	

		

			
Suggestions for RT-PCR validation

			

				
F: 
GAGACGCTGTCAGACATGCAG

				
R: 
GAGAAGTTCTGGTTGGCGGTC

				
Band lengths: 
247-359

			

		

	





	
Functional annotations
(Submit an annotation)

	


There are 0 annotated functions for this event 


		










GENOMIC CONTEXT[edit]












INCLUSION PATTERN[edit]






SPECIAL DATASETS
  • Pre-implantation embryo development
  • Neural differentiation time course
  • Muscular differentiation time course
  • Spermatogenesis cell types
  • Reprogramming of fibroblasts to iPSCs
  • Hematopoietic precursors and cell types






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