Special

MmuEX0014962 @ mm9

Exon Skipping

Gene
ENSMUSG00000021879 | Dnahc12
Description
dynein, axonemal, heavy chain 12 [Source:MGI Symbol;Acc:MGI:107720]
Coordinates
chr14:27542983-27544120:+
Coord C1 exon
chr14:27542983-27543117
Coord A exon
chr14:27543341-27543534
Coord C2 exon
chr14:27543877-27544120
Length
194 bp
Sequences
Splice sites
3' ss Seq
GGACATTTGTTTGCTTTTAGTAT
3' ss Score
5.5
5' ss Seq
ACGGTAATT
5' ss Score
7.31
Exon sequences
Seq C1 exon
CTCATTGAGAATGCTAAACATGCAAAAGAAAATGAACTAATAGCCAAGAGAGAAAAACTGATTTTGGAAATAGAAAAAGAATCACGTCGCATGGAGGAGTTCACCGAGTTTGCAGAACTGGACCGCATGCATCAG
Seq A exon
TATGTGGCAGATGTAAGACAACTGCAGAAACGGATTCAGGAATCGGAAGAAGCTGTTCAGTTTATTAATAAAGAAGAGGAACTTTTCAAATGGGAATTGACAAAGTATCCTGAGCTGGAAAAATTAAAAGTCACCATTGAGCCCTACCAGAAGTTTTTTAATTTTGTTCTGAAGTGGCAGCGAACAGAAAAACG
Seq C2 exon
GTGGATGGATGGAGGGTTTCTGGACCTTAATGGAGAAAGTATGGAAGCTGACATAGATGACTTTTCCAGAGAAGTTTTTAGGACACTGAAGTTCTTCCATGCTAAGCAAAAGAAAGAATTACAAGAAAGAAGAAAGGCAGCAAGAAAACGATCTTTGATGGAAGAGAAACCTGAAGAAGAACCAAAAGAGAATCCTACAATTACTATGTGTACCACAGTAATGGAGCAGATAAAGTCTTTTAAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000021879-'14-16,'14-15,15-16
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact





	

	
ORF disruption upon sequence exclusion





No structure available

		

			
Features


			

				
Disorder rate (Iupred):
  C1=0.022 A=0.000 C2=0.298
 
                        

				
Domain overlap (PFAM):

					





						

							
C1:
NO

							
A:
PF083938=DHC_N2=PU(6.3=43.1)

							
C2:
PF083938=DHC_N2=FE(18.3=100)

						

					

				








    
Main Inclusion Isoform:
ENSMUSP00000022433





     
                   









    
Main Skipping Isoform:
NA





     
      









    
Other Inclusion Isoforms:
ENSMUSP00000123745
          









    
Other Skipping Isoforms:
NA
  



Associated events






Other assemblies


mm10




Conservation


Human
(hg38)
chr3:57470443-57470636 
HIGH PSI
HsaEX6056765
(DNAH12)
Human
(hg19)
chr3:57456170-57456363 
HIGH PSI
HsaEX6056765
(DNAH12)
Rat
(rn6)
chr16:2409593-2409786 
HIGH PSI
RnoEX6054507
(Dnah12)
Cow
(bosTau6)
chr22:44240030-44240223 
HIGH PSI
BtaEX0000771
([1])
Chicken
(galGal4)
chr12:8689429-8689622 
ALTERNATIVE
GgaEX1001313
([2])
Chicken
(galGal3)
chr12:8937461-8937654 
HIGH PSI
GgaEX1001313
([3])
Zebrafish
(danRer10)
chr23:19622309-19622502 
HIGH PSI
DreEX6079809
(dnah12)
Fruitfly
(dm6)
No conservation detected




Primers PCR

	

		

			
Suggestions for RT-PCR validation

			

				
F: 
TTTGCAGAACTGGACCGCATG

				
R: 
TCTGCTCCATTACTGTGGTACA

				
Band lengths: 
257-451

			

		

	





	
Functional annotations
(Submit an annotation)

	


There are 0 annotated functions for this event 


		










GENOMIC CONTEXT[edit]












INCLUSION PATTERN[edit]






SPECIAL DATASETS
  • Pre-implantation embryo development
  • Neural differentiation time course
  • Muscular differentiation time course
  • Spermatogenesis cell types
  • Reprogramming of fibroblasts to iPSCs
  • Hematopoietic precursors and cell types






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