Special

MmuEX0015489 @ mm9

Exon Skipping

Gene
ENSMUSG00000022102 | Dok2
Description
docking protein 2 [Source:MGI Symbol;Acc:MGI:1332623]
Coordinates
chr14:71175273-71176804:+
Coord C1 exon
chr14:71175273-71175554
Coord A exon
chr14:71175791-71175878
Coord C2 exon
chr14:71176623-71176804
Length
88 bp
Sequences
Splice sites
3' ss Seq
CCCGGGACCTGCCTCCTCAGGGA
3' ss Score
7.13
5' ss Seq
CAGGTGAGA
5' ss Score
9.22
Exon sequences
Seq C1 exon
AAGTGGCGCCGGTTCGCAGCCGTGTTATATGGAGAGTCTGGCTGTGCCCTAGCCAGACTAGAGCTCCAGGATGTCCCCGAGAAGACACGGCGAGGAGAGGCCACTCGGAAGGTTGTCCGCCTCAGTGACTGCTTACGGGTAGCAGAGGTAGGCAGTGAGGCCAGCAGCCCCCGGGACACCAGTGCCTTCATCCTGGAGACCAAGGAGCGCCTGTACCTACTGGCAGCCCCCTCGGCAGAGCGCAGTGACTGGATACAGGCCATCTGCCTGTTGGCTTTCCCG
Seq A exon
GGACAGAGGAAAGGGTCACCAGGACTGGAGGAAAAGAGCGGCAGTCCCTGCATGGAGGAGAACGAGTTGTATAGCAGCTCCACCACAG
Seq C2 exon
GGCTCTGCAAGGAATATATGGTGACCATACGACCCACAGAAGCCAGTGAGCGCTGCCGGCTCCGAGGGTCCTATACTCTCCGGACCGGGGTGAGTGCCCTGGAGCTGTGGGGTGGCCCTGAGCCAGGCACACAGCTATATGACTGGCCCTACAGGTTTCTTCGACGCTTTGGGCGTGACAAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000022102-'8-17,'8-13,11-17
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact





	

	
ORF disruption upon sequence exclusion





No structure available

		

			
Features


			

				
Disorder rate (Iupred):
  C1=0.032 A=0.433 C2=0.000
 
                        

				
Domain overlap (PFAM):

					





						

							
C1:
PF0016924=PH=PD(83.5=96.8)

							
A:
NO

							
C2:
PF0217412=IRS=PU(58.0=95.1)

						

					

				








    
Main Inclusion Isoform:
ENSMUSP00000022698





     
                   









    
Main Skipping Isoform:
NA





     
      









    
Other Inclusion Isoforms:
NA
          









    
Other Skipping Isoforms:
NA
  



Associated events






Other assemblies


mm10




Conservation


Human
(hg38)
chr8:21911901-21911988 
ALTERNATIVE
HsaEX0020682
(DOK2)
Human
(hg19)
chr8:21769412-21769499 
ALTERNATIVE
HsaEX0020682
(DOK2)
Rat
(rn6)
chr15:52452868-52452955 
HIGH PSI
RnoEX0029426
(Dok2)
Cow
(bosTau6)
chr8:69727564-69727651 
HIGH PSI
BtaEX6034647
(DOK2)
Chicken
(galGal4)
chr22:1378678-1378778 
Chicken
(galGal3)
chr22:1373646-1373744 
Zebrafish
(danRer10)
chr8:42565305-42565407 
HIGH PSI
DreEX6051166
(dok2)
Fruitfly
(dm6)
No conservation detected




Primers PCR

	

		

			
Suggestions for RT-PCR validation

			

				
F: 
GGTAGCAGAGGTAGGCAGTGA

				
R: 
TGTGGGTCGTATGGTCACCAT

				
Band lengths: 
183-271

			

		

	





	
Functional annotations
(Submit an annotation)

	


There are 0 annotated functions for this event 


		










GENOMIC CONTEXT[edit]












INCLUSION PATTERN[edit]






SPECIAL DATASETS
  • Pre-implantation embryo development
  • Neural differentiation time course
  • Muscular differentiation time course
  • Spermatogenesis cell types
  • Reprogramming of fibroblasts to iPSCs
  • Hematopoietic precursors and cell types






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