Special

MmuEX0015708 @ mm9

Exon Skipping

Gene
ENSMUSG00000024331 | Dsc2
Description
desmocollin 2 [Source:MGI Symbol;Acc:MGI:103221]
Coordinates
chr18:20196554-20200454:-
Coord C1 exon
chr18:20200198-20200454
Coord A exon
chr18:20199936-20200078
Coord C2 exon
chr18:20196554-20196778
Length
143 bp
Sequences
Splice sites
3' ss Seq
TCCTTCACTGTGGTTAACAGGTA
3' ss Score
7.7
5' ss Seq
CAGGTAAGA
5' ss Score
10.77
Exon sequences
Seq C1 exon
CCTCTGGACTATGAAGAACGGCAACAGGTGACCCTGCAAATTGGAGTAGTTAATGAAGCTCCATACACTAGAGAGGCTAGCTCAAAGTCACCCATGAGCACAGCCACAGTGACTGTCACCGTGACAAATCAGGATGAGGGCCCCGAGTGTATCCCTCCAATGCAAACTGTGAGGATTCAAGAAAATGTACCAGTTGGGACTAGAAATGATGGATATAAGGCATATGACCCAGAGACCAGAAGCAGCAGTGGCATAAG
Seq A exon
GTACAGAAAGTTAAGTGACCCAAGAGGGTGGGTCACTGTTAATGAAGATTCAGGATCGATCACTATTTTCCGAGCGTTGGATCGAGAGGCTGAGACTGTCAGAAATGGCATTTACAATATTACAGTCCTTGCGTTAGATGCAG
Seq C2 exon
ATGGGAGAAGCTGTACTGGAACTCTGGGAATCATACTTGAAGATGTGAATGATAATGGCCCATTCATACCCAAGCAGACAGTGGTGATATGCAAGGCTACCATGTCCTCTGCTGAAATTGTTGCAGTTGATCTCGATGATCCAGTGAATGGCCCACCATTTGATTTCAGTTTGGAGAGCTCTGATTCGGAAGTTCAGAGGATGTGGAGGCTAACAAGAATCAATG
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000024331-'15-12,'15-11,16-12
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact





	

	
ORF disruption upon sequence exclusion





No structure available

		

			
Features


			

				
Disorder rate (Iupred):
  C1=0.698 A=0.020 C2=0.000
 
                        

				
Domain overlap (PFAM):

					





						

							
C1:
PF0002812=Cadherin=PD(39.4=47.7),PF0002812=Cadherin=PU(33.3=36.0)

							
A:
PF0002812=Cadherin=FE(51.6=100)

							
C2:
PF0002812=Cadherin=PD(14.0=17.1)

						

					

				








    
Main Inclusion Isoform:
ENSMUSP00000074702





     
                   









    
Main Skipping Isoform:
NA





     
      









    
Other Inclusion Isoforms:
ENSMUSP00000042905
          









    
Other Skipping Isoforms:
NA
  



Associated events






Other assemblies


mm10




Conservation


Human
(hg38)
chr18:31079847-31079989 
HIGH PSI
HsaEX6038497
(DSC2)
Human
(hg19)
chr18:28659813-28659955 
HIGH PSI
HsaEX6038497
(DSC2)
Rat
(rn6)
chr18:11837411-11837553 
HIGH PSI
RnoEX6058151
(Dsc2)
Cow
(bosTau6)
chr24:26364446-26364579 
HIGH PSI
BtaEX6091730
(DSC2)
Chicken
(galGal4)
chr2:105640874-105641016 
HIGH PSI
GgaEX6021412
([1])
Chicken
(galGal3)
chr2:109116035-109116177 
HIGH PSI
GgaEX6021412
(F1NJD7_CHICK)
Zebrafish
(danRer10)
chr20:7283952-7284094 
HIGH PSI
DreEX0028373
(dsc2l)
Fruitfly
(dm6)
No conservation detected




Primers PCR

	

		

			
Suggestions for RT-PCR validation

			

				
F: 
GACAAATCAGGATGAGGGCCC

				
R: 
AGCAGAGGACATGGTAGCCTT

				
Band lengths: 
248-391

			

		

	





	
Functional annotations
(Submit an annotation)

	


There are 0 annotated functions for this event 


		










GENOMIC CONTEXT[edit]












INCLUSION PATTERN[edit]






SPECIAL DATASETS
  • Pre-implantation embryo development
  • Neural differentiation time course
  • Muscular differentiation time course
  • Spermatogenesis cell types
  • Reprogramming of fibroblasts to iPSCs
  • Hematopoietic precursors and cell types






Retrieved from "https://vastdb.crg.eu/wiki/Special:VastDB"