Special

MmuEX0015767 @ mm10

Exon Skipping

Gene
ENSMUSG00000026131 | Dst
Description
dystonin [Source:MGI Symbol;Acc:MGI:104627]
Coordinates
chr1:34291787-34294546:+
Coord C1 exon
chr1:34291787-34291916
Coord A exon
chr1:34293320-34293483
Coord C2 exon
chr1:34294384-34294546
Length
164 bp
Sequences
Splice sites
3' ss Seq
CTGAAGTTGTGTTTTACCAGGGA
3' ss Score
5.21
5' ss Seq
GAGGTCAGA
5' ss Score
5.24
Exon sequences
Seq C1 exon
ACCTTCATGGAAGAAATGACCAGAAAACAGCCCGACGTTGATAAAGTTACCAAGACCTATAAGAGGAGGGCCACTGACCCTCCCTCGTTACAGTCTCACATCCCCGTCTTGGACAAGGGACGAGCCGGAA
Seq A exon
GGAAACGCTTCCCAGCCTCGGGCTTCTATCCATCTGGCTCACAGACGCAAATCGAGACCAAGAACCCCAGGGTTAACCTGCTGGTGAGCAAGTGGCAGCAGGTCTGGCTCCTGGCCTTGGAAAGGAGGAGGAAGCTCAACGACGCCCTGGACAGGCTGGAGGAG
Seq C2 exon
CTGAGGGAATTTGCCAACTTCGATTTCGACATCTGGCGGAAAAAATACATGAGGTGGATGAACCATAAGAAATCGAGAGTGATGGATTTCTTCCGGAGAATTGATAAGGACCAGGATGGGAAGATCACTCGACAGGAATTCATCGACGGGATTCTCTCCTCCA
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000026131-'174-163,'174-161,175-163
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact





	

	
ORF disruption upon sequence exclusion





No structure available

		

			
Features


			

				
Disorder rate (Iupred):
  C1=0.500 A=0.144 C2=0.000
 
                        

				
Domain overlap (PFAM):

					





						

							
C1:
PF0043516=Spectrin=PD(44.2=77.3)

							
A:
PF134991=EF-hand_7=PU(2.2=3.6)

							
C2:
PF134991=EF-hand_7=PU(55.4=74.5)

						

					

				








    
Main Inclusion Isoform:
ENSMUSP00000095392





     
                   









    
Main Skipping Isoform:
NA





     
      









    
Other Inclusion Isoforms:
ENSMUSP00000095393, ENSMUSP00000110756, ENSMUSP00000138308, ENSMUSP00000138426, ENSMUSP00000138570, ENSMUSP00000141127
          









    
Other Skipping Isoforms:
NA
  



Associated events






Other assemblies


mm9




Conservation


Human
(hg38)
chr6:56472059-56472222 
ALTERNATIVE
HsaEX0021046
(DST)
Human
(hg19)
chr6:56336857-56337020 
ALTERNATIVE
HsaEX0021046
(DST)
Rat
(rn6)
chr9:37917117-37917280 
HIGH PSI
RnoEX0030040
(Dst)
Cow
(bosTau6)
chr23:3672124-3672287 
HIGH PSI
BtaEX6096638
(DST)
Chicken
(galGal4)
chr3:86529924-86530087 
HIGH PSI
GgaEX7003298
(DST)
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
chr13:1561718-1561884 
HIGH PSI
DreEX6059673
(FQ311894.1)
Fruitfly
(dm6)
No conservation detected




Primers PCR

	

		

			
Suggestions for RT-PCR validation

			

				
F: 
ATGACCAGAAAACAGCCCGAC

				
R: 
TCCTGTCGAGTGATCTTCCCA

				
Band lengths: 
252-416

			

		

	





	
Functional annotations
(Submit an annotation)

	


There are 0 annotated functions for this event 


		










GENOMIC CONTEXT[edit]












INCLUSION PATTERN[edit]






SPECIAL DATASETS
  • Pre-implantation embryo development
  • Ribosome-engaged transcriptomes of neuronal types
  • Neural differentiation time course
  • Muscular differentiation time course
  • Spermatogenesis cell types
  • Reprogramming of fibroblasts to iPSCs
  • Hematopoietic precursors and cell types





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