Special

MmuEX0022712 @ mm9

Exon Skipping

Gene
ENSMUSG00000020721 | Helz
Description
helicase with zinc finger domain [Source:MGI Symbol;Acc:MGI:1925705]
Coordinates
chr11:107507364-107517562:+
Coord C1 exon
chr11:107507364-107507547
Coord A exon
chr11:107510426-107510654
Coord C2 exon
chr11:107517358-107517562
Length
229 bp
Sequences
Splice sites
3' ss Seq
TTCTTTCAATGTTTTTCTAGGAA
3' ss Score
10.53
5' ss Seq
TAGGTAAGT
5' ss Score
9.66
Exon sequences
Seq C1 exon
GTATTTGAAGTGGTGGAGCGTGTAGAAGAGCTAAGACGGAAGTGGCCAGTGGCATGGGGAAAGTTAGATGACGGCAGCATCGGTGTGGTGACGCCATACGCTGACCAGGTGTTTAGAATCCGAGCTGAGCTTCGGAAGAAGAGGCTCTCGGATGTGAATGTGGAAAGGGTGCTCAATGTCCAAG
Seq A exon
GAAAGCAGTTCAGAGTTCTGTTTCTTAGCACAGTGCGTACACGCCACACTTGCAAGCACAAGCAGACGCCAATTAAAAAGAAAGAGCAACTCCTGGAAGACTCCACCGAGGACTTAGATTATGGTTTTCTATCCAACTACAAACTTCTCAATACGGCCATCACCAGAGCACAGTCCTTGGTTGCTGTGGTGGGTGACCCTGTTGCTCTGTGCTCTATTGGAAGGTGTAG
Seq C2 exon
AAAGTTTTGGGAGCGGTTTATTGCCCTGTGTCATGAAAACCACAGCTTGCACGGGATCACGTTCGAACAGATCAAGGCACAGTTAGAGGCTTTAGAACTCAAGAAGACTTACGTGTTGAATCCACTGGCTCCTGAGTTTATCCCCCGGGCTTTACGACTGCAGCATTCAGGAAACAGTAGCAGACAGCAGCAGTCACCACCCAAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000020721-'28-28,'28-27,29-28
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact





	

	
ORF disruption upon sequence exclusion





No structure available

		

			
Features


			

				
Disorder rate (Iupred):
  C1=0.000 A=0.013 C2=0.232
 
                        

				
Domain overlap (PFAM):

					





						

							
C1:
PF130871=AAA_12=FE(28.6=100)

							
A:
PF130871=AAA_12=PD(31.5=87.0)

							
C2:
PF0714510=PAM2=WD(100=26.1)

						

					

				








    
Main Inclusion Isoform:
ENSMUSP00000074533f826A





     
                   









    
Main Skipping Isoform:
NA





     
      









    
Other Inclusion Isoforms:
ENSMUSP00000074533, ENSMUSP00000097878, ENSMUSP00000102357, ENSMUSP00000117498
          









    
Other Skipping Isoforms:
NA
  



Associated events






Other assemblies


mm10




Conservation


Human
(hg38)
chr17:67135970-67136198 
ALTERNATIVE
HsaEX0029676
(HELZ)
Human
(hg19)
chr17:65132086-65132314 
ALTERNATIVE
HsaEX0029676
(HELZ)
Rat
(rn6)
chr10:95869694-95869889 
HIGH PSI
RnoEX0041510
(Helz)
Cow
(bosTau6)
chr19:63815284-63815512 
HIGH PSI
BtaEX6091294
(HELZ)
Chicken
(galGal4)
chr18:7168658-7168886 
Chicken
(galGal3)
chr18:7210972-7211200 
HIGH PSI
GgaEX6016286
(HELZ)
Zebrafish
(danRer10)
chr3:60771676-60771904 
HIGH PSI
DreEX0037287
(helz)
Fruitfly
(dm6)
No conservation detected




Primers PCR

	

		

			
Suggestions for RT-PCR validation

			

				
F: 
AGTGGTGGAGCGTGTAGAAGA

				
R: 
GAGCCAGTGGATTCAACACGT

				
Band lengths: 
307-536

			

		

	





	
Functional annotations
(Submit an annotation)

	


There are 0 annotated functions for this event 


		










GENOMIC CONTEXT[edit]












INCLUSION PATTERN[edit]






SPECIAL DATASETS
  • Pre-implantation embryo development
  • Neural differentiation time course
  • Muscular differentiation time course
  • Spermatogenesis cell types
  • Reprogramming of fibroblasts to iPSCs
  • Hematopoietic precursors and cell types






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