Special

MmuEX0024685 @ mm9

Exon Skipping

Gene
ENSMUSG00000026971 | Itgb6
Description
integrin beta 6 [Source:MGI Symbol;Acc:MGI:96615]
Coordinates
chr2:60507159-60511768:-
Coord C1 exon
chr2:60511459-60511768
Coord A exon
chr2:60510689-60510768
Coord C2 exon
chr2:60507159-60507363
Length
80 bp
Sequences
Splice sites
3' ss Seq
CTTGCTGGCTTTGCTCTTAGGTG
3' ss Score
9.21
5' ss Seq
GAGGTAAAT
5' ss Score
8.39
Exon sequences
Seq C1 exon
GAAGTTGCTTTTAAACACAGCTTTTCTGCTTTGCCTGTCCAGGTAGCTTCTGTTTTCATTTTAGTCTTAGTGAAAGGTTTTGAATTTACAGCTCAAGTTACTTTTCAAAGCAGTGTGAGTAGTTTTACTTAAAAAACAAAACAAAACCAAAAACCCCGGCAAGAAAGACTTTCACGGCTTCCAGCTTTGGTCTTGTAACCCTGAAGGTAATTCATTTTTAATCTGTCTGCACAGTGAAAACTGAACCGAATGGGGATTGAGCTGGTCTGCCTGTTTCTGCTACTTCTAGGAAGGAATGATCACGTCCAAG
Seq A exon
GTGGCTGTGCCTGGGGTGGTGCAGAAAGCTGCTCAGACTGCCTGCTCACAGGACCCCACTGCGCCTGGTGCTCCCAGGAG
Seq C2 exon
AATTTCACCCACCTGTCTGGAGCTGGCGAGAGGTGCGACACCCCAGCGAATCTTTTAGCCAAAGGATGTCAACTACCCTTCATTGAAAACCCTGTCTCCCGCATAGAAGTCCTTCAAAATAAGCCTCTCAGCGTGGGCCGACAGAAGAACAGTTCTGACATTGTTCAGATTGCTCCTCAAAGCTTGGTTCTTAAATTGAGACCAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000026971_CASSETTE1
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact





	

	
ORF disruption upon sequence exclusion





No structure available

		

			
Features


			

				
Disorder rate (Iupred):
  C1=0.000 A=0.000 C2=0.000
 
                        

				
Domain overlap (PFAM):

					





						

							
C1:
NO

							
A:
PF0036213=Integrin_beta=PU(4.0=63.0)

							
C2:
PF0036213=Integrin_beta=FE(16.0=100)

						

					

				








    
Main Inclusion Isoform:
ENSMUSP00000028348





     
                   









    
Main Skipping Isoform:
NA





     
      









    
Other Inclusion Isoforms:
ENSMUSP00000054944, ENSMUSP00000108136, ENSMUSP00000117815
          









    
Other Skipping Isoforms:
NA
  



Associated events






Other assemblies


mm10




Conservation


Human
(hg38)
chr2:160199179-160199258 
ALTERNATIVE
HsaEX0032479
(ITGB6)
Human
(hg19)
chr2:161055690-161055769 
ALTERNATIVE
HsaEX0032479
(ITGB6)
Rat
(rn6)
chr3:46725971-46726050 
HIGH PSI
RnoEX0045249
(Itgb6)
Cow
(bosTau6)
chr2:36257395-36257474 
HIGH PSI
BtaEX0018553
(ITGB6)
Chicken
(galGal4)
chr7:21294433-21294512 
HIGH PSI
GgaEX1030797
(ITGB6)
Chicken
(galGal3)
chr7:23383007-23383086 
HIGH PSI
GgaEX1030797
(E1C6K8_CHICK)
Zebrafish
(danRer10)
chr11:11002449-11002528 
HIGH PSI
DreEX0040188
(itgb6)
Fruitfly
(dm6)
No conservation detected




Primers PCR

	

		

			
Suggestions for RT-PCR validation

			

				
F: 
CGAATGGGGATTGAGCTGGTC

				
R: 
TCTATGCGGGAGACAGGGTTT

				
Band lengths: 
171-251

			

		

	





	
Functional annotations
(Submit an annotation)

	


There are 0 annotated functions for this event 


		










GENOMIC CONTEXT[edit]












INCLUSION PATTERN[edit]






SPECIAL DATASETS
  • Pre-implantation embryo development
  • Neural differentiation time course
  • Muscular differentiation time course
  • Spermatogenesis cell types
  • Reprogramming of fibroblasts to iPSCs
  • Hematopoietic precursors and cell types






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