Special

MmuEX0028763 @ mm9

Exon Skipping

Gene
ENSMUSG00000041975 | Mettl8
Description
methyltransferase like 8 [Source:MGI Symbol;Acc:MGI:2385142]
Coordinates
chr2:70802618-70805213:-
Coord C1 exon
chr2:70805107-70805213
Coord A exon
chr2:70804505-70804570
Coord C2 exon
chr2:70802618-70803736
Length
66 bp
Sequences
Splice sites
3' ss Seq
TCTCTTTTGTCATATTTTAGGGC
3' ss Score
11.24
5' ss Seq
AAGGTATGC
5' ss Score
9.55
Exon sequences
Seq C1 exon
GATGCAAGCTGTTGCCCACCGACTGTCCAGGTTGCTGAAGCCCGGAGGAATGCTATTGTTTCGGGATCATGGAAGATACGATAATGCTCAGCTTCGTTTTAAGAAAG
Seq A exon
GGCGTTGTTTATCTGAAAATTTTTATGTCCGAGGAGATGGTACCAGAGCTTATTTCTTTACAAAAG
Seq C2 exon
GGGAAATCCGCCGTATGTTCTGCGAGGCTGGATTACACGAAAAGCAAAATCTGGTTGATCATCGCTTGCAAGTGAACAGGAAAAAGCAAGTGCAGATGCACCGAGTGTGGATTCAAGGAAAATTCCAGAAACCATCGCCCTGGACTCCACAGAGTGGAAATTAGCATTCACTGCATTCTCAGGACCGAACTATGTGTCATGTTAAAGTATGAACCCAGGGCCTGATACTGTTCAAAGACTTCTCTTCCAGAGATGAGCAGAAGAGCATCCGCAGCTCTGCTGGTCTGCTGTCAGTGCTCTCAGGACATTTTAAGAACAAGGATGTGACTTGAAAGAGTCTCCCACCCTCTGGGTTTCCAGAACTTGAAATGTATGTTTGGTTTTGTTTCATCTAACCATGTTCCCTTGAATTGTATGACTTTGAATTAAGAAGCGTATAGTTTTGAGAAATGTAACCCGTCCATGTTTTAGAAGTGGAAAAATGATCTACTTTATTGTTG
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000041975-'15-20,'15-18,18-20
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact





	

	
Alternative protein isoforms (Ref)





No structure available

		

			
Features


			

				
Disorder rate (Iupred):
  C1=0.000 A=0.000 C2=0.106
 
                        

				
Domain overlap (PFAM):

					





						

							
C1:
PF082417=Methyltransf_11=PD(18.7=54.1)

							
A:
PF134891=Methyltransf_23=FE(11.6=100)

							
C2:
PF134891=Methyltransf_23=PD(8.4=29.1)

						

					

				








    
Main Inclusion Isoform:
ENSMUSP00000107804





     
                   









    
Main Skipping Isoform:
NA





     
      









    
Other Inclusion Isoforms:
ENSMUSP00000068750, ENSMUSP00000097615, ENSMUSP00000118026
          









    
Other Skipping Isoforms:
NA
  



Associated events






Other assemblies


mm10




Conservation


Human
(hg38)
No conservation detected
Human
(hg19)
chr2:172182351-172182416 
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
chr2:25153835-25153900 
HIGH PSI
BtaEX6009087
(METTL8)
Chicken
(galGal4)
chr7:17560013-17560078 
HIGH PSI
GgaEX1035995
(METTL8)
Chicken
(galGal3)
chr7:19512352-19512417 
HIGH PSI
GgaEX1035995
(METTL8)
Zebrafish
(danRer10)
chr9:3560993-3561058 
HIGH PSI
DreEX0046149
(mettl8)
Fruitfly
(dm6)
No conservation detected




Primers PCR

	

		

			
Suggestions for RT-PCR validation

			

				
F: 
CGACTGTCCAGGTTGCTGAAG

				
R: 
TTCCTGTTCACTTGCAAGCGA

				
Band lengths: 
170-236

			

		

	





	
Functional annotations
(Submit an annotation)

	


There are 0 annotated functions for this event 


		










GENOMIC CONTEXT[edit]












INCLUSION PATTERN[edit]






SPECIAL DATASETS
  • Pre-implantation embryo development
  • Neural differentiation time course
  • Muscular differentiation time course
  • Spermatogenesis cell types
  • Reprogramming of fibroblasts to iPSCs
  • Hematopoietic precursors and cell types






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