Special

MmuEX6030298 @ mm9

Exon Skipping

Gene
ENSMUSG00000024913 | Lrp5
Description
low density lipoprotein receptor-related protein 5 [Source:MGI Symbol;Acc:MGI:1278315]
Coordinates
chr19:3614226-3620304:-
Coord C1 exon
chr19:3620015-3620304
Coord A exon
chr19:3615653-3615879
Coord C2 exon
chr19:3614226-3614410
Length
227 bp
Sequences
Splice sites
3' ss Seq
TTCTTTCCTCATCTTCGCAGACG
3' ss Score
9.93
5' ss Seq
AGGGTAAGG
5' ss Score
9.16
Exon sequences
Seq C1 exon
GAACCAACCCATGTGCGGATGGAAATGGAGGGTGCAGCCATCTGTGCTTCTTCACCCCACGTGCCACCAAGTGTGGCTGCCCCATTGGCCTGGAGCTGTTGAGTGACATGAAGACCTGCATAATCCCCGAGGCCTTCCTGGTATTCACCAGCAGAGCCACCATCCACAGGATCTCCCTGGAGACTAACAACAACGATGTGGCTATCCCACTCACGGGTGTCAAAGAGGCCTCTGCACTGGACTTTGATGTGTCCAACAATCACATCTACTGGACTGATGTCAGCCTCAAG
Seq A exon
ACGATCAGCCGAGCCTTCATGAATGGGAGCTCAGTGGAGCACGTGATTGAGTTTGGCCTCGACTACCCTGAAGGAATGGCTGTGGACTGGATGGGCAAGAACCTCTATTGGGCGGACACAGGGACCAACAGGATTGAGGTGGCCCGGCTGGATGGGCAGTTCCGGCAGGTGCTTGTGTGGAGAGACCTTGACAACCCCAGGTCTCTGGCTCTGGATCCTACTAAAGG
Seq C2 exon
CTACATCTACTGGACTGAGTGGGGTGGCAAGCCAAGGATTGTGCGGGCCTTCATGGATGGGACCAATTGTATGACACTGGTAGACAAGGTGGGCCGGGCCAACGACCTCACCATTGATTATGCCGACCAGCGACTGTACTGGACTGACCTGGACACCAACATGATTGAGTCTTCCAACATGCTGG
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000024913-'17-14,'17-13,18-14=AN
Average complexity
A_S
Mappability confidence:
100%=100=100%
Protein Impact





	

	
ORF disruption upon sequence exclusion





No structure available

		

			
Features


			

				
Disorder rate (Iupred):
  C1=0.000 A=0.000 C2=0.000
 
                        

				
Domain overlap (PFAM):

					





						

							
C1:
PF146701=FXa_inhibition=WD(100=37.1),PF0005812=Ldl_recept_b=PU(24.4=10.3)

							
A:
PF0005812=Ldl_recept_b=PD(70.7=38.2),PF0005812=Ldl_recept_b=WD(100=53.9),PF0005812=Ldl_recept_b=PU(0.1=0.0)

							
C2:
PF0005812=Ldl_recept_b=WD(100=65.1),PF0005812=Ldl_recept_b=PU(51.4=30.2)

						

					

				








    
Main Inclusion Isoform:
ENSMUSP00000025856





     
                   









    
Main Skipping Isoform:
NA





     
      









    
Other Inclusion Isoforms:
ENSMUSP00000025856f1653A, ENSMUSP00000134771
          









    
Other Skipping Isoforms:
NA
  



Associated events






Other assemblies


mm10




Conservation


Human
(hg38)
chr11:68409914-68410140 
HIGH PSI
HsaEX6003456
(LRP5)
Human
(hg19)
chr11:68177382-68177608 
HIGH PSI
HsaEX6003456
(LRP5)
Rat
(rn6)
chr1:218850355-218850581 
HIGH PSI
RnoEX6005906
(Lrp5)
Cow
(bosTau6)
chr29:46536500-46536726 
HIGH PSI
BtaEX6104007
(LRP5)
Chicken
(galGal4)
chr5:15799596-15799822 
HIGH PSI
GgaEX0009979
(LRP5)
Chicken
(galGal3)
chr5:17683100-17683326 
HIGH PSI
GgaEX0009979
(Q5ZKF9_CHICK)
Zebrafish
(danRer10)
chr25:10576832-10577058 
HIGH PSI
DreEX6101261
(lrp5)
Fruitfly
(dm6)
No conservation detected




Primers PCR

	

		

			
Suggestions for RT-PCR validation

			

				
F: 
GTATTCACCAGCAGAGCCACC

				
R: 
GGTGTCCAGGTCAGTCCAGTA

				
Band lengths: 
307-534

			

		

	





	
Functional annotations
(Submit an annotation)

	


There are 0 annotated functions for this event 


		










GENOMIC CONTEXT[edit]












INCLUSION PATTERN[edit]










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