Special

MmuEX6052934 @ mm10

Exon Skipping

Gene
ENSMUSG00000022272 | Myo10
Description
myosin X [Source:MGI Symbol;Acc:MGI:107716]
Coordinates
chr15:25778081-25780412:+
Coord C1 exon
chr15:25778081-25778187
Coord A exon
chr15:25779583-25779810
Coord C2 exon
chr15:25780364-25780412
Length
228 bp
Sequences
Splice sites
3' ss Seq
CTGGCCGCTCTCTCTTGCAGAAA
3' ss Score
12.09
5' ss Seq
AAGGTATGT
5' ss Score
9.79
Exon sequences
Seq C1 exon
GTCTTCCTTCGAGAATCCTTGGAGCAGAAACTGGAAAAGAGGCGGGAAGAGGAGATTGACCGTGCGGCCATGGTGATCCGAGCTCACATCTTAGGCTACTTGGCACG
Seq A exon
AAAGCAATATAGAAAGGTCCTCTGTGGTGTGGTGACCATACAGAAGAATTACAGAGCTTTCCTTGCGAGGAAGAAATTTTTGCACCTGAAAAAGGCAGCCATCGTGTTCCAGAAGCAACTGCGAGGACAGCTGGCACGCAGGGTTTACAGGCAGCTGTTGGCTGAGAAACGGGAGCTGGAGGAAAAGAAGAGGCGGGAGGAAGAGAAGAAGAGAGAGGAAGAGGAAAG
Seq C2 exon
AGAAAGAGAGCGAGCGCAAAGAGAAGCTGACCTCCTCCGTGCCCATCAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000022272-'49-50,'49-47,52-50
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact





	

	
Alternative protein isoforms (Ref)





No structure available

		

			
Features


			

				
Disorder rate (Iupred):
  C1=0.000 A=0.167 C2=0.860
 
                        

				
Domain overlap (PFAM):

					





						

							
C1:
PF0006316=Myosin_head=FE(43.4=100),PF0061222=IQ=PU(76.2=43.2)

							
A:
PF0006316=Myosin_head=PD(7.2=7.8),PF0061222=IQ=PD(19.0=5.2),PF0061222=IQ=WD(100=26.0),PF0061222=IQ=WD(100=27.3)

							
C2:
NO

						

					

				








    
Main Inclusion Isoform:
ENSMUSP00000106087





     
                   









    
Main Skipping Isoform:
NA





     
      









    
Other Inclusion Isoforms:
ENSMUSP00000022882, ENSMUSP00000118280, ENSMUSP00000118744, ENSMUSP00000120566, ENSMUSP00000120817, ENSMUSP00000123057
          









    
Other Skipping Isoforms:
NA
  



Associated events







Other assemblies


mm9




Conservation


Human
(hg38)
chr5:16702925-16703158 
HIGH PSI
HsaEX6097489
(MYO10)
Human
(hg19)
chr5:16703034-16703267 
HIGH PSI
HsaEX6097489
(MYO10)
Rat
(rn6)
chr2:78037348-78037575 
HIGH PSI
RnoEX6009019
(Myo10)
Cow
(bosTau6)
chr20:56538874-56539107 
HIGH PSI
BtaEX6075916
(MYO10)
Chicken
(galGal4)
chr2:75608892-75609101 
HIGH PSI
GgaEX7002063
(MYO10)
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
chr2:42779085-42779309 
HIGH PSI
DreEX6028687
(myo10)
Fruitfly
(dm6)
No conservation detected




Primers PCR

	

		

			
Suggestions for RT-PCR validation

			

				
F: 
GTCTTCCTTCGAGAATCCTTGGA

				
R: 
CTGATGGGCACGGAGGAGG

				
Band lengths: 
156-384

			

		

	





	
Functional annotations
(Submit an annotation)

	


There are 2 annotated functions for this event 


PMID: 20731332
HsaEX6097489
Encodes an experimentally validated Eukaryotic Linear Motif (ELM). Method: comigration in gel electrophoresis, competition binding. ELM ID: ELMI001883; ELM sequence: LYCVVIIQKNYRAFLLRRRF; Overlap: FULL


PMID: 20731332
HsaEX6097489
Encodes an experimentally validated Eukaryotic Linear Motif (ELM). Method: comigration in gel electrophoresis, competition binding. ELM ID: ELMI001884; ELM sequence: KKAAIVFQKQLRGQIARRVY; Overlap: FULL


		










GENOMIC CONTEXT[edit]












INCLUSION PATTERN[edit]






SPECIAL DATASETS
  • Ribosome-engaged transcriptomes of neuronal types
  • Neural differentiation time course
  • Muscular differentiation time course
  • Spermatogenesis cell types
  • Reprogramming of fibroblasts to iPSCs
  • Hematopoietic precursors and cell types





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