Special

MmuEX6100607 @ mm9

Exon Skipping

Gene
ENSMUSG00000059013 | Sh2d3c
Description
SH2 domain containing 3C [Source:MGI Symbol;Acc:MGI:1351631]
Coordinates
chr2:32600271-32602666:+
Coord C1 exon
chr2:32600271-32600399
Coord A exon
chr2:32601355-32601809
Coord C2 exon
chr2:32602542-32602666
Length
455 bp
Sequences
Splice sites
3' ss Seq
TTTCTCCGTTCCTTCTGTAGGTC
3' ss Score
13.56
5' ss Seq
CAGGTCAGC
5' ss Score
7.16
Exon sequences
Seq C1 exon
TTCTCCAAGGAGAAGTACATTCTTGACTCCTCGCCAGAGAAACTGCACAAGGAGCTGGAAGAGGAACTGAAGCTCAGCAGCACGGACCTCCGTAGCCATGCCTGGTACCACGGACGCATCCCTCGTGAG
Seq A exon
GTCTCTGAGACTCTGGTGCAGCGGAACGGCGACTTCCTCATCCGAGACTCACTCACCAGCCTAGGGGACTATGTGCTCACGTGCCGCTGGCACAATCAGGCCTTGCACTTCAAGATCAACAAGGTGGTGGTGAAGGCCGGAGAGAGCTACACCCACATCCGGTACCTCTTCGAGCAGGAGAGCTTCGACCACGTGCCTGCCCTCGTGCGCTACCACGTGGGCAGCCGTAAGGCCGTGTCCGAACAGAGCGGGGCTATCATCTACTGCCCTGTCAACCGCACCTTCCCACTGCGCTACCTCGAGGCCAGCTATGGCCTGAGCCAGGGCAGCAGCAAGACTGCCAGCCCAGCCAGCCCCTCAGGCTCCAAGGGCAGCCACATGAAGAGGCGAAGCATTACCATGACTGATGGACTCACCACTGACAAGGTCACCCGCAGCGATGGCTGCCCCAACAG
Seq C2 exon
CACCTCATTACCCCATCCTCGAGACTCCATCCGAAACTGTGCCCTCAGCATGGACCAGATCCCAGATCTCCACTCACCCCTGTCTCCTATCTCCGAGAGCCCCAGCTCTCCTGCCTATAGCACTG
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000059013-'11-11,'11-10,12-11=AN
Average complexity
A_S
Mappability confidence:
100%=100=100%
Protein Impact





	

	
ORF disruption upon sequence exclusion





No structure available

		

			
Features


			

				
Disorder rate (Iupred):
  C1=0.054 A=0.283 C2=1.000
 
                        

				
Domain overlap (PFAM):

					





						

							
C1:
PF0001719=SH2=PU(9.9=18.6)

							
A:
PF0001719=SH2=PD(87.7=46.7),PF0500012=RNA_pol_Rpb1_4=PU(74.5=25.0)

							
C2:
PF0500012=RNA_pol_Rpb1_4=PD(23.5=80.0)

						

					

				








    
Main Inclusion Isoform:
ENSMUSP00000073866





     
                   









    
Main Skipping Isoform:
NA





     
      









    
Other Inclusion Isoforms:
ENSMUSP00000108868, ENSMUSP00000122613
          









    
Other Skipping Isoforms:
NA
  



Associated events






Other assemblies


mm10




Conservation


Human
(hg38)
chr9:127749211-127749665 
HsaEX6063126
(SH2D3C)
Human
(hg19)
chr9:130511490-130511944 
HIGH PSI
HsaEX6063126
(SH2D3C)
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
chr11:98444974-98445428 
HIGH PSI
BtaEX6046286
(SH2D3C)
Chicken
(galGal4)
chr17:4917568-4918016 
ALTERNATIVE
GgaEX0006885
(SH2D3C)
Chicken
(galGal3)
chr17:5545758-5546206 
HIGH PSI
GgaEX0006885
(SH2D3C)
Zebrafish
(danRer10)
chr10:10296313-10296740 
HIGH PSI
DreEX6087248
(sh2d3ca)
Fruitfly
(dm6)
No conservation detected




Primers PCR

	

		

			
Suggestions for RT-PCR validation

			

				
F: 
GAAGTACATTCTTGACTCCTCGCC

				
R: 
CTATAGGCAGGAGAGCTGGGG

				
Band lengths: 
238-693

			

		

	





	
Functional annotations
(Submit an annotation)

	


There are 0 annotated functions for this event 


		










GENOMIC CONTEXT[edit]












INCLUSION PATTERN[edit]










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