Special

MmuEX6101030 @ mm9

Exon Skipping

Gene
ENSMUSG00000049252 | Lrp1b
Description
low density lipoprotein-related protein 1B (deleted in tumors) [Source:MGI Symbol;Acc:MGI:2151136]
Coordinates
chr2:41167996-41200138:-
Coord C1 exon
chr2:41199938-41200138
Coord A exon
chr2:41197211-41197456
Coord C2 exon
chr2:41167996-41168193
Length
246 bp
Sequences
Splice sites
3' ss Seq
AAGTATCTGTCCCTTTACAGATG
3' ss Score
10.34
5' ss Seq
TGGGTGAGT
5' ss Score
8.73
Exon sequences
Seq C1 exon
GGAGATGCATCAACAATGCCTGGGTATGTGATGGAGATGTTGACTGTGAAGATCAGTCTGATGAAGAAGACTGTGACAGTTTCTTGTGTGGACCACCCAAGTACCCTTGTGCTAATGACACCTCTGTGTGCCTGCAGCCAGAGAAACTCTGCAATGGGAGGAAGGACTGTCCAGATGGGTCAGATGAAGGCGACCTTTGTG
Seq A exon
ATGAGTGTTCTCTGAACAATGGAGGGTGTAGCAACCACTGTTCTGTTGTTCCTGGAAGAGGAATTGTCTGTTCCTGCCCAGAAGGACATCAGCTCAAGAAAGACAATAGAACATGTGAAATCGTGGACTACTGTGCCTCCCACCTGAGGTGCAGCCAAGTGTGTGAGCAGCAAAAACATATGGTCAAGTGCTCCTGCTATGAAGGCTGGGCGTTGGGGACTGATGGGGAAAGCTGCACCAGTGTGG
Seq C2 exon
ATTCTTTTGAGGCATTCATCATCTTTTCTATACGCCATGAAATTCGAAGGATTGATCTGCATAAAGGAGACTACAGCCTACTTGTTCCTGGACTGAGAAATACCATAGCACTTGATTTTCACTTCAATCAAAGTTTACTTTACTGGACAGATGTTGTGGAAGACAGAATATACAGGGGCAAGCTGTCAGAGAGTGGAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000049252-'25-26,'25-25,26-26=AN
Average complexity
A_S
Mappability confidence:
100%=100=100%
Protein Impact





	

	
Alternative protein isoforms (Ref)





No structure available

		

			
Features


			

				
Disorder rate (Iupred):
  C1=0.000 A=0.000 C2=0.000
 
                        

				
Domain overlap (PFAM):

					





						

							
C1:
PF0005713=Ldl_recept_a=PD(61.5=35.3),PF0005713=Ldl_recept_a=PU(92.9=57.4)

							
A:
PF0005713=Ldl_recept_a=PD(4.8=2.4),PF146701=FXa_inhibition=WD(100=44.6),PF146701=FXa_inhibition=WD(100=41.0)

							
C2:
PF0005812=Ldl_recept_b=PU(48.9=32.8)

						

					

				








    
Main Inclusion Isoform:
ENSMUSP00000054275f4696A





     
                   









    
Main Skipping Isoform:
NA





     
      









    
Other Inclusion Isoforms:
ENSMUSP00000054275, ENSMUSP00000129192
          









    
Other Skipping Isoforms:
NA
  



Associated events






Other assemblies


mm10




Conservation


Human
(hg38)
chr2:140902920-140903165 
ALTERNATIVE
HsaEX6015732
(LRP1B)
Human
(hg19)
chr2:141660489-141660734 
HIGH PSI
HsaEX6015732
(LRP1B)
Rat
(rn6)
chr3:25962947-25963192 
HIGH PSI
RnoEX6016698
(AABR07051892.1)
Cow
(bosTau6)
chr2:56235585-56235830 
Chicken
(galGal4)
chr7:31518556-31518801 
HIGH PSI
GgaEX6043154
(LRP1B)
Chicken
(galGal3)
chr7:33634383-33634628 
HIGH PSI
GgaEX6043154
(LRP1B)
Zebrafish
(danRer10)
chr9:36658482-36658727 
HIGH PSI
DreEX0043704
(lrp1bb)
Fruitfly
(dm6)
No conservation detected




Primers PCR

	

		

			
Suggestions for RT-PCR validation

			

				
F: 
GACCACCCAAGTACCCTTGTG

				
R: 
TCTGACAGCTTGCCCCTGTAT

				
Band lengths: 
301-547

			

		

	





	
Functional annotations
(Submit an annotation)

	


There are 0 annotated functions for this event 


		










GENOMIC CONTEXT[edit]












INCLUSION PATTERN[edit]










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