DmeEX6007488 @ dm6
Exon Skipping
Gene
FBgn0013810 | Dhc36C
Description
The gene Dynein heavy chain at 36C is referred to in FlyBase by the symbol DmelDhc36C (CG5526, FBgn0013810). It is a protein_coding_gene from Dmel. It has 3 annotated transcripts and 3 polypeptides (2 unique). Gene sequence location is 2L:17501401..17525515. Its molecular function is described by: ATP binding; dynein light intermediate chain binding; ATP-dependent microtubule motor activity, minus-end-directed; dynein intermediate chain binding. It is involved in the biological process described with: cilium movement; microtubule-based movement; sensory perception of sound. 9 alleles are reported. No phenotypic data is available. The phenotypic classes of alleles include: neurophysiology defective; viable; auditory perception defective. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed at stages throughout the pupal period, in adult male stages.
Coordinates
chr2L:17506875-17508857:+
Coord C1 exon
chr2L:17506875-17508170
Coord A exon
chr2L:17508230-17508676
Coord C2 exon
chr2L:17508744-17508857
Length
447 bp
Sequences
Splice sites
3' ss Seq
AACATATTGTGGCGTTCTAGGCT
3' ss Score
7.12
5' ss Seq
CAGGTGCGT
5' ss Score
9.73
Exon sequences
Seq C1 exon
TGGATACGAGGATGATAAACTGCTCGTTGCCGTATGGCTATGAATATTTGGGAAACACCCCACGACTGGTGGTTACTCCACTCACAGATCGTTGCTATCGTACCCTGTTCGCTGCCTTGAATCTGCATTTGGGTGGTGCGCCTGAAGGTCCTGCCGGCACTGGCAAAACGGAGACCACCAAGGATCTGGCCAAGGCTGTTGCCAAACAATGTGTGGTATTTAATTGTTCGGATGGTTTGGATTACCTCGCTTTGGGTAAGTTCTTTAAGGGGCTGGCATCTTGCGGTGCATGGTCCTGCTTCGATGAGTTCAACCGAATCGATCTGGAGGTGCTCTCTGTGGTGGCACAGCAGATCTTGACCATTCAGCGTGGCATCAACTCGGGCAGCCCCACGTTGGTCTTCGAAGGCACCACTTTGACACTGGATCCTACTTGTGCTGTGTTCATTACCATGAATCCTGGTTACGCCGGACGTTCTGAGTTGCCCGATAACCTCAAG
Seq A exon
GCTCTCTTCCGTTCGGTGGCCATGATGGTGCCGGATTATGCCCTGATCTCGGAGATTGAGCTGTACTCTTATGGTTTCCTGACCGCCAAACCGCTGTCCGTTAAGATTGTGGCCACATATCGCCTGTGTTCCGAGCAGTTGAGTACACAGTGCCACTACGATTATGGCATGAGAGCCGTAAAGTCGGTGCTGAAAGCAGCCGGTGCTTTGAAACTTCGCTATCGGGATGAGAACGAGGATATCCTGGTGTTGCGCTCCATTAAGGATGTAAATTTGCCCAAGTTTCTTAACCAGGATATTCCCCTGTTCCAGGGCATCACCTCTGATCTGTTTCCTGGAACAGTTTTGCCGGAAGCGGACTACGTACTATTCAATAAATGTACACAGATGGCTTGTGAAAGACAAAATAAGCAGTGCACTCCATTTGTGCTGGAGAAGGTGCAACAG
Seq C2 exon
TTGTATGAGATGATAGTGGTGCGGCATGGTCTTATGTTGGTGGGTTATCCATTTGGGGGCAAGACAACCACATATCGCGTCCTAGCGGAGGCCTTGGAGTGTATGGAGAAAACG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0013810-'7-8,'7-7,8-8=AN
Average complexity
A_S
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (Ref)
No structure available
Features
Disorder rate (Iupred):
C1=0.021 A=0.000 C2=0.000
Domain overlap (PFAM):
C1:
PF083938=DHC_N2=PD(36.6=35.0),PF127742=AAA_6=PU(67.1=35.9)
A:
PF127742=AAA_6=PD(32.0=49.7)
C2:
PF077289=AAA_5=PU(19.6=73.7)
Main Inclusion Isoform:
FBpp0293284
Main Skipping Isoform:
NA
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
NA
Associated events
Conservation
Mouse
(mm9)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
TTTAAGGGGCTGGCATCTTGC
R:
TCCATACACTCCAAGGCCTCC
Band lengths:
344-791
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)