Special

DmeEX6016395 @ dm6

Exon Skipping

Gene
Description
The gene sticky is referred to in FlyBase by the symbol Dmelsti (CG10522, FBgn0002466). It is a protein_coding_gene from Dmel. It has 3 annotated transcripts and 3 polypeptides (2 unique). Gene sequence location is 3L:12507998..12514815. Its molecular function is described by: ATP binding; protein serine/threonine kinase activity. It is involved in the biological process described with 12 unique terms, many of which group under: nervous system development; chromosome organization; regulation of cellular component biogenesis; metabolic process; central nervous system development. 29 alleles are reported. The phenotypes of these alleles manifest in: imaginal tissue; male-specific anatomical entity; follicle cell; intracellular organelle; spermatocyte. The phenotypic classes of alleles include: increased mortality; phenotype; sterile; modifier of variegation. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages.
Coordinates
chr3L:12513462-12514815:-
Coord C1 exon
chr3L:12514382-12514815
Coord A exon
chr3L:12513881-12514125
Coord C2 exon
chr3L:12513462-12513824
Length
245 bp
Sequences
Splice sites
3' ss Seq
TATCTAATTTCCTACTCCAGTTC
3' ss Score
7.12
5' ss Seq
CAGGTTTGT
5' ss Score
7.44
Exon sequences
Seq C1 exon
CTCTGGAAAGTGAGCACGCATCCCTGGCTCTTCGGCTTCCCTCGGCGCATTTTTTTCAAAGCGAAACGGCAGAAAAATGCTCTGGCATTTTACGGATTTCTAATTGTATTATTTATGTGAGAAAATTGCAAATAAAAGTGAGTCCATCATGCCACCCAAGATGGAGCCGATTAGCGTGCGCACCGCGCGTCTGAACAACCTGATTCTGGGCAAAGGAGCTGGCGTCTGTGCGAAGCCCGCTGGAAGCGCCTCCGGATCAGGTATTCCCGCCTCCACCAGGAGAAGCATTGTACCCGTGAGCACCACTAGCGCCGCCGTGGCCGAGGCCATCTGCCGCGAGGGACTCCTGGACGCCTTCTGTCTGCTGTACAACGAGTGCGACAAGGATACGCTGAAGAAGCGCGATCGCAACATCGCCGAGTTTGTCAACAAAT
Seq A exon
TTCGTCCCATCATAGAGGAGACCCGCAAACTCAGGGTCAACGCAGATGACTTCCTCATCAAGACGCTTATTGGCCAAGGATACTTTGGCAACGTTCACCTGGTGGTGGAGCGGCAAACCAACGACATATACGCCATGAAGAAGATCAAAAAGTCGGTGGTGACGACGTCACAAGTCAAGGAGGAGCGCGATATCATGTCCATTCGCAACTCTGAATGGCTAATCAATCTGCAGTATGCCTTTCAG
Seq C2 exon
GATAACGACAATCTGTACCTGGTCATGGAGTACATGCCCGGCGGAGACCTTCTCAGCTTGATGTCACGCCACGGCCCTTTCGATGAGGACTTGGCTCGTTTCTATCTGGCCGAGCTCACAGTGGCCCTGCACACATTGCACGAGATGGGCTATGTGCATCGGGATATAAAGCCTGAAAATATACTGATTGATCGTTTTGGCCATATTAAACTGGCTGATTTCGGTAATGCCGCTGCCTTGGATCGCGATGGCCATGTGCTGAGTTTGTCGCCGGTGGGAACACCGGATTACATAGCTCCAGAGCTGCTGCAAACCATATCCACCTACAAGCTGTCCAAGTCGATGCACGATGTGAGTAGAATT
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0002466-'0-1,'0-0,1-1=AN
Average complexity
A_S
Mappability confidence:
100%=100=100%
Protein Impact

ORF disruption upon sequence exclusion

No structure available
Features
Disorder rate (Iupred):
  C1=0.073 A=0.000 C2=0.000
Domain overlap (PFAM):

C1:
NO
A:
PF0006920=Pkinase=PU(24.0=78.0)
C2:
PF0006920=Pkinase=FE(44.3=100)


Main Inclusion Isoform:
FBpp0304889


Main Skipping Isoform:
NA


Other Inclusion Isoforms:
FBpp0075702


Other Skipping Isoforms:
NA
Associated events
Conservation
Mouse
(mm9)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
HIGH PSI
(CIT)
Chicken
(galGal3)
HIGH PSI
(CIT)
Zebrafish
(danRer10)
HIGH PSI
(CIT)
Primers PCR
Suggestions for RT-PCR validation
F:
GAAGCATTGTACCCGTGAGCA
R:
TAGCCCATCTCGTGCAATGTG
Band lengths:
305-550
Functional annotations
There are 0 annotated functions for this event


GENOMIC CONTEXT[edit]

INCLUSION PATTERN[edit]


SPECIAL DATASETS

  • Neural diversity
  • Neurogenesis
  • Neuronal activity
  • Splicing factor regulation (brain)
  • Splicing factor regulation (SL2)