DreEX6038636 @ danRer10

Exon Skipping

Gene

ENSDARG00000086819 | scn1a

Description

sodium channel, voltage-gated, type I, alpha [Source:ZFIN;Acc:ZDB-GENE-040426-751]

Coordinates

chr9:50259642-50267419:-

Coord C1 exon

chr9:50267356-50267419

Coord A exon

chr9:50264625-50264766

Coord C2 exon

chr9:50259642-50259848

Length

142 bp

Sequences

Splice sites

3' ss Seq

GCCACATGTGTGCATTTCAGGCA

3' ss Score

7.51

5' ss Seq

CAGGTGTGT

5' ss Score

6.99

Exon sequences

Seq C1 exon

GTAATCAATATTTCCTACCAGGAAAAAAAGATGCACTGATCTGTGGAAATTCTTCTGATGCTGG

Seq A exon

GCAGTGTCCAGAGGGATATACGTGTTTAAAAGCAGGTAACAATCCAGATTATGGTTACACAAGCTTTGATTCGTTCGGCTGGGCTTTCCTTTCCTTGTTCAGACTGATGACTCAAGACTTCTGGGAGAATCTTTACCAACAG

Seq C2 exon

ACTCTTCGGGCCGCTGGGAAAACCTATATGATTTTTTTCGTGCTGGTCATTTTCTTGGGATCCTTCTACCTGGTGAACCTCATCCTGGCTGTAGTCGCCATGGCATACGACGAACAGAATCAAGCCACGATCGACGAGGCTTTGAAAAAAGAGGAAGAGTTCAACGCCATGCTTGAGCAGATCACGAGACAGGAGCAGGAAGCTGAG

VastDB Features

Vast-tools module Information

Secondary ID

ENSDARG00000086819-'14-14,'14-13,15-14=AN

Average complexity

A_S

Mappability confidence:

100%=100=100%

Protein Impact

ORF disruption upon sequence exclusion

No structure available

Features

Disorder rate (Iupred):

C1=0.000 A=0.000 C2=0.130

Domain overlap (PFAM):

C1:

PF146251=Lustrin_cystein=PU(50.0=86.4),PF0052026=Ion_trans=PU(18.4=81.8)

A:

PF146251=Lustrin_cystein=PD(47.4=37.5),PF0052026=Ion_trans=FE(48.0=100),PF0382411=NicO=PU(17.3=47.9),PF0253517=Zip=PU(14.4=47.9),PF057587=Ycf1=PU(11.2=41.7),PF0479111=LMBR1=PU(9.0=27.1)

C2:

PF0052026=Ion_trans=PD(32.7=45.7),PF0382411=NicO=FE(51.9=100),PF0253517=Zip=FE(43.1=100),PF057587=Ycf1=FE(38.5=100),PF0479111=LMBR1=FE(47.6=100),PF0293211=Neur_chan_memb=PU(34.2=90.0),PF074236=DUF1510=PU(49.6=88.6)

Main Inclusion Isoform:

ENSDARP00000138437