GgaEX0021336 @ galGal3
Exon Skipping
Gene
ENSGALG00000014632 | Q5ZJ82_CHICK
Description
NA
Coordinates
chr25:1645975-1648420:+
Coord C1 exon
chr25:1645975-1646209
Coord A exon
chr25:1647896-1647992
Coord C2 exon
chr25:1648354-1648420
Length
97 bp
Sequences
Splice sites
3' ss Seq
TCCCTGTCTGCCTGGGCCAGCAG
3' ss Score
3.69
5' ss Seq
GATGTACAG
5' ss Score
-3.25
Exon sequences
Seq C1 exon
CTACGACGACCACTCAGCAGACAGGAGGGCCTACGACCGCCGTTACTGTGACAGCTACCGGCGCAACGATTACAGCCGTGAGCGAGGAGAGCCCTACTACGACCCCGAGTACCGGCATTCCTACGAGTACCGGCGCTCCCGGGACCGCGACGGCAGCTACCGGAGCTGCAAAAGCAGCCGGCGTAAGCACAGGCGGAGGCGGCGGCGCAGCCGGTCCTTTAGTCGCTCCTCATCG
Seq A exon
CAGCGGAGTCGACAGAGCAGCAGAAGGGCCAAGAGTGTGGAGGACGACGACGAGGGGCATCTGATCTATCGCGTCGGCGACTGGCTACAAGAAAGAT
Seq C2 exon
ATGAGATTCTCAGCACTTTAGGGGAAGGCACGTTCGGCAGAGTGGTGCAGTGCATGGATCACCGGAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSGALG00000014632_CASSETTE1
Average complexity
S*
Mappability confidence:
NA
Protein Impact
ORF disruption upon sequence exclusion
Show structural model
Features
Disorder rate (Iupred):
C1=0.835 A=0.406 C2=0.000
Domain overlap (PFAM):
C1:
NO
A:
PF0006920=Pkinase=PU(0.1=0.0)
C2:
PF0006920=Pkinase=PU(6.9=95.7)
Main Skipping Isoform:
NA
Other Skipping Isoforms:
NA
Associated events
Conservation
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
CTACTACGACCCCGAGTACCG
R:
GTGCCTTCCCCTAAAGTGCTG
Band lengths:
173-270
Functional annotations
There are 1 annotated functions for this event
PMID: 16371011
Skipping of exon 4 (HsaEX0015698) increases in brain areas affected by Alzheimer's Disease resulting in increased expression levels of clk2tr. Increased expression of clk2 full-length induces skipping of clk2 exon 4. Increased expression of clk2tr does not promote skipping of clk2 exon 4.