HsaEX0015698 @ hg38
Exon Skipping
Gene
ENSG00000176444 | CLK2
Description
CDC like kinase 2 [Source:HGNC Symbol;Acc:HGNC:2069]
Coordinates
chr1:155268293-155269716:-
Coord C1 exon
chr1:155269488-155269716
Coord A exon
chr1:155268708-155268795
Coord C2 exon
chr1:155268293-155268359
Length
88 bp
Sequences
Splice sites
3' ss Seq
CCCCCCCTGCCCCCCGACAGCAG
3' ss Score
7.45
5' ss Seq
GATGTACAA
5' ss Score
-5.41
Exon sequences
Seq C1 exon
CAGTTATGATGATCGTTCGTCCGACCGGAGGGTGTATGACCGGCGATACTGTGGCAGCTACAGACGCAACGATTATAGCCGGGATCGGGGAGATGCCTACTATGACACAGACTATCGGCATTCCTATGAATATCAGCGGGAGAACAGCAGTTACCGCAGCCAGCGCAGCAGCCGGAGGAAGCACAGACGGCGGAGGAGGCGCAGCCGGACATTTAGCCGCTCATCTTCG
Seq A exon
CAGCACAGCAGCCGGAGAGCCAAGAGTGTAGAGGACGACGCTGAGGGCCACCTCATCTACCACGTCGGGGACTGGCTACAAGAGCGAT
Seq C2 exon
ATGAAATCGTTAGCACCTTAGGAGAGGGGACCTTCGGCCGAGTTGTACAATGTGTTGACCATCGCAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSG00000176444-'15-17,'15-13,17-17
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact
ORF disruption upon sequence exclusion
Show PDB structure
Features
Disorder rate (Iupred):
C1=0.803 A=0.311 C2=0.000
Domain overlap (PFAM):
C1:
NO
A:
PF0006920=Pkinase=PU(0.1=0.0)
C2:
PF0006920=Pkinase=PU(6.9=95.7)
Main Skipping Isoform:
NA
Other Skipping Isoforms:
NA
Associated events
Other assemblies
Conservation
Primers PCR
Suggestions for RT-PCR validation
F:
CGGGGAGATGCCTACTATGACA
R:
CGAAGGTCCCCTCTCCTAAGG
Band lengths:
180-268
Functional annotations
There are 1 annotated functions for this event
PMID: 16371011
Skipping of exon 4 (HsaEX0015698) increases in brain areas affected by Alzheimer's Disease resulting in increased expression levels of clk2tr. Increased expression of clk2 full-length induces skipping of clk2 exon 4. Increased expression of clk2tr does not promote skipping of clk2 exon 4.
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- The Cancer Genome Atlas (TCGA)
- Genotype-Tissue Expression Project (GTEx)
- Autistic and control brains
- Pre-implantation embryo development