HsaEX0014006 @ hg19

Exon Skipping

Gene

ENSG00000164045 | CDC25A

Description

cell division cycle 25 homolog A (S. pombe) [Source:HGNC Symbol;Acc:1725]

Coordinates

chr3:48219344-48224520:-

Coord C1 exon

chr3:48224419-48224520

Coord A exon

chr3:48222211-48222330

Coord C2 exon

chr3:48219344-48219478

Length

120 bp

Sequences

Splice sites

3' ss Seq

GTCTCAACTATGTCTTGCAGGAA

3' ss Score

8.06

5' ss Seq

ATGGTATGT

5' ss Score

8.35

Exon sequences

Seq C1 exon

CAGAAGCTGTTGGGATGTAGTCCAGCTCTGAAGAGGAGCCATTCTGATTCTCTTGACCATGACATCTTTCAGCTCATCGACCCAGATGAGAACAAGGAAAAT

Seq A exon

GAAGCCTTTGAGTTTAAGAAGCCAGTAAGACCTGTATCTCGTGGCTGCCTGCACTCTCATGGACTCCAGGAGGGTAAAGATCTCTTCACACAGAGGCAGAACTCTGCCCCAGCTCGGATG

Seq C2 exon

CTTTCCTCAAATGAAAGAGATAGCAGTGAACCAGGGAATTTCATTCCTCTTTTTACACCCCAGTCACCTGTGACAGCCACTTTGTCTGATGAGGATGATGGCTTCGTGGACCTTCTCGATGGAGAGAATCTGAAG

VastDB Features

Vast-tools module Information

Secondary ID

ENSG00000164045_CASSETTE1

Average complexity

S

Mappability confidence:

100%=100=100%

Protein Impact

Alternative protein isoforms (Ref)

No structure available

Features

Disorder rate (Iupred):

C1=0.537 A=0.700 C2=0.985

Domain overlap (PFAM):

C1:

PF066178=M-inducer_phosp=FE(55.0=100),PF066178=M-inducer_phosp=PU(0.1=0.0)

A:

PF066178=M-inducer_phosp=FE(16.0=100)

C2:

PF066178=M-inducer_phosp=PD(1.7=2.2),PF066178=M-inducer_phosp=FE(29.9=100)

Main Inclusion Isoform:

ENSP00000303706

Main Skipping Isoform:

ENSP00000343166

Other Inclusion Isoforms:

ENSP00000416483

Other Skipping Isoforms:

NA

Associated events

HsaEX6055704

Other assemblies

hg38

Conservation

Mouse

(mm10)

chr9:109881473-109881577

HIGH PSI

MmuEX0010349

(Cdc25a)

Mouse

(mm9)

chr9:109783977-109784081

HIGH PSI

MmuEX0010349

(Cdc25a)

Rat

(rn6)

chr8:117959371-117959490

HIGH PSI

RnoEX0018899

(Cdc25a)

Cow

(bosTau6)

chr22:52249875-52249994

HIGH PSI

BtaEX0008042

(CDC25A)

Chicken

(galGal4)

chr2:572107-572223

ALTERNATIVE

GgaEX0006750

(CDC25A)

Chicken

(galGal3)

chr2:478311-478427

ALTERNATIVE

GgaEX0006750

(CDC25A)

Zebrafish

(danRer10)

No conservation detected

Fruitfly

(dm6)

No conservation detected

Primers PCR

Suggestions for RT-PCR validation

F:

CAGAAGCTGTTGGGATGTAGTC

R:

CTCCATCGAGAAGGTCCACGA

Band lengths:

226-346

Functional annotations

(Submit an annotation)

There are 0 annotated functions for this event

GENOMIC CONTEXT[edit]

INCLUSION PATTERN[edit]

SPECIAL DATASETS

The Cancer Genome Atlas (TCGA)
Genotype-Tissue Expression Project (GTEx)
Autistic and control brains
Pre-implantation embryo development

Other AS DBs:

FasterDB (Includes CLIP-seq data)

AS-ALPS (AS-induced ALteration of Protein Structure, links to PINs)

APPRIS (Selection of principal isoform)

DEU primates (Only for human)

Special

HsaEX0014006 @ hg19

GENOMIC CONTEXT[edit]

INCLUSION PATTERN[edit]

SPECIAL DATASETS