HsaEX6055704 @ hg19
Exon Skipping
Gene
ENSG00000164045 | CDC25A
Description
cell division cycle 25 homolog A (S. pombe) [Source:HGNC Symbol;Acc:1725]
Coordinates
chr3:48222211-48225326:-
Coord C1 exon
chr3:48225290-48225326
Coord A exon
chr3:48224419-48224520
Coord C2 exon
chr3:48222211-48222330
Length
102 bp
Sequences
Splice sites
3' ss Seq
TTCCTTTTTTACTTTGATAGCAG
3' ss Score
5.42
5' ss Seq
AATGTGAGT
5' ss Score
7.8
Exon sequences
Seq C1 exon
CCTTGAAAATCCTATGAGAAGAATACATTCCCTACCT
Seq A exon
CAGAAGCTGTTGGGATGTAGTCCAGCTCTGAAGAGGAGCCATTCTGATTCTCTTGACCATGACATCTTTCAGCTCATCGACCCAGATGAGAACAAGGAAAAT
Seq C2 exon
GAAGCCTTTGAGTTTAAGAAGCCAGTAAGACCTGTATCTCGTGGCTGCCTGCACTCTCATGGACTCCAGGAGGGTAAAGATCTCTTCACACAGAGGCAGAACTCTGCCCCAGCTCGGATG
VastDB Features
Vast-tools module Information
Secondary ID
ENSG00000164045-'4-8,'4-6,5-8=AN
Average complexity
A_C1
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (Ref)
No structure available
Features
Disorder rate (Iupred):
C1=0.885 A=0.537 C2=0.700
Domain overlap (PFAM):
C1:
PF066178=M-inducer_phosp=FE(20.0=100)
A:
PF066178=M-inducer_phosp=FE(55.0=100),PF066178=M-inducer_phosp=PU(0.1=0.0)
C2:
PF066178=M-inducer_phosp=FE(16.0=100)
Main Skipping Isoform:
NA
Other Skipping Isoforms:
NA
Associated events
Other assemblies
Conservation
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
CCTATGAGAAGAATACATTCCCTACC
R:
ATCCGAGCTGGGGCAGAG
Band lengths:
146-248
Functional annotations
There are 1 annotated functions for this event
PMID: 12411508
This event
Encodes an experimentally validated Eukaryotic Linear Motif (ELM). Method: alanine scanning, detection by mass spectrometry, inhibitor, protein kinase assay. ELM ID: ELMI003208; ELM sequence: LGCSPALK; Overlap: FULL
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Autistic and control brains
Other AS DBs:
FasterDB (Includes CLIP-seq data)
AS-ALPS (AS-induced ALteration of Protein Structure, links to PINs)
APPRIS (Selection of principal isoform)
DEU primates (Only for human)