HsaEX0026562 @ hg38
Exon Skipping
Gene
ENSG00000162613 | FUBP1
Description
far upstream element binding protein 1 [Source:HGNC Symbol;Acc:HGNC:4004]
Coordinates
chr1:77968165-77970015:-
Coord C1 exon
chr1:77969925-77970015
Coord A exon
chr1:77969022-77969084
Coord C2 exon
chr1:77968165-77968203
Length
63 bp
Sequences
Splice sites
3' ss Seq
TCTTTTTATTTTATGTGTAGATG
3' ss Score
7.62
5' ss Seq
AAGGCAGGA
5' ss Score
1.7
Exon sequences
Seq C1 exon
ATTGCAGCAAAAATTGGAGGTGATGCAGGGACATCACTGAATTCAAATGACTATGGTTATGGGGGACAAAAAAGACCTTTAGAAGATGGAG
Seq A exon
ATGGCTCTTGGACAAGTCCGAGCAGTACAACACACTGGGAGGGAATGCCCTCTCCTTTTAAAG
Seq C2 exon
ATCAACCAGATGCTAAGAAAGTTGCTCCTCAAAATGACT
VastDB Features
Vast-tools module Information
Secondary ID
ENSG00000162613_CASSETTE1
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (No Ref)
Show PDB structure
Features
Disorder rate (Iupred):
C1=0.941 A=1.000 C2=1.000
Domain overlap (PFAM):
C1:
NO
A:
NO
C2:
NO
Other Inclusion Isoforms:
NA
Associated events
Other assemblies
Conservation
Zebrafish
(danRer10)
No conservation detected
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
TGCAGCAAAAATTGGAGGTGA
R:
AGTCATTTTGAGGAGCAACTTTCT
Band lengths:
128-191
Functional annotations
There are 1 annotated functions for this event
PMID: 31911676
[CRISPR screen]. Conserved poison exon with negative fitness/survivability impact when depleted: HeLa Depleted at 14 days (FC=0.748, FDR=0.000), PC9 Depleted at 14 days (FC=0.663, FDR=0.000), Late Xenograft No change (FC=0.803, FDR=0.015).
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- The Cancer Genome Atlas (TCGA)
- Genotype-Tissue Expression Project (GTEx)
- Autistic and control brains
- Pre-implantation embryo development