HsaINT0005078 @ hg19
Intron Retention
Gene
ENSG00000181026 | AEN
Description
apoptosis enhancing nuclease [Source:HGNC Symbol;Acc:25722]
Coordinates
chr15:89172457-89175512:+
Coord C1 exon
chr15:89172457-89172657
Coord A exon
chr15:89172658-89173288
Coord C2 exon
chr15:89173289-89175512
Length
631 bp
Sequences
Splice sites
5' ss Seq
CAGGTGCGT
5' ss Score
9.73
3' ss Seq
GTGTTGGCTCTCGTCAGTAGGTG
3' ss Score
5.58
Exon sequences
Seq C1 exon
ATCCTTAAGCTCCTGAAGGGCAAGGTGGTGGTGGGGCACGCGCTGCACAACGACTTCCAGGCGCTCAAGTATGTCCACCCTCGGAGCCAGACCCGGGATACGACCTATGTCCCAAACTTCCTCAGCGAGCCCGGCCTCCACACCCGGGCCCGGGTCTCTCTAAAGGACCTGGCCCTGCAGCTGCTGCACAAGAAGATCCAG
Seq A exon
GTGCGTGGTGGGAGAGTGGCTGGAAGGGAGGGAGGCCCGCCTGGCCTCCATGCCACCTGAGCCACAGACAAGGCTTTGGGCTGTGTCTCCAGCCTCCTTGTCATTCTCTTCCCTAGTCCAGGTCCAGGGACCTTGCTTAAATGGGTCTCCCTCCTGTACACGCAGCTCCAGGTGTTTCTCTCCATGATCCTTCTTCCCCAGTGTGTACTGCGATTCTCCCAGAACACATTCTCCTAGGCCGATCTCTTCCAGATCTGTCCCCTCCCTAACTCTTGGTTCTTGCATCCCTGAAGCATGGTCTCCCATCCCCTACTAGCAGACATAGAGCCTTAGATCAGGAGGAGCCAGTACCTCTTGCTCCTGTTGGGCTTCACATTTATTATTCATCTGATCTGCAAGCCTTTGAAGCAAGAGATTTTTAGCATGCCTTATATTTGAGGAAAACAGGCTTGGAGAAGCTGCATGGCTTATGGTGTACAGTTGAGGTTCCATCCCTTTTCTGTGAACCTCCATTCTGAGCATACGTATTCTTGGGCCTGCACAAAGAGCCCTGGGAAACTGGCCTTGCTTCTTGGGGTAACAGGCCTCTCACTAGGCCTGCAGGCAGTGATGTGTTGGCTCTCGTCAGTAG
Seq C2 exon
GTGGGCCAGCACGGGCACTCATCAGTAGAAGATGCCACGACAGCCATGGAGCTCTACCGGCTGGTGGAGGTGCAGTGGGAACAGCAGGAGGCCCGCAGCCTCTGGACCTGCCCCGAGGACAGAGAACCTGACAGCAGCACAGACATGGAACAGTACATGGAGGACCAGTACTGGCCCGATGACCTGGCCCACGGCAGCAGAGGAGGAGCCAGGGAGGCACAGGACAGAAGGAATTGAGAAGGGGGCGGGGCTCCCTGGCTGGGCTTCCGGTGTGGCCGGTAGGAAGTGGGGGCCAGGAGAGCAGCGGGCACTCCTTCCTGGGCAGGGTGGGGCAGGATGCAGTGAGCCAGCCCCAGGGCCAGAGGAGTAGGGGTCATCTGTTACCTTGACACCCTCTGCACACAGCATAGCCCTCTCTCTCTCCAGGGCTGTTGGTTCTTTCTTCTGACTCCTGTGGTTTTGCTAATGGCACTTTACAGACTCCATGGAGATGTCAGGTGGACCATCTTCTAGGGCCCAGCAGGAGTAGGGAATGTGCCAACAGACTGCCCAGGTTGCCGTGGCCTTCCCCACCCCCCAGATCTCCTGAGTCATCATGCTGTGCTAATGAAAGGGATCATATCATCCTCTCTGGGGATGGTGGGTGGGGGTGTCAATATCCTGGAGCTCCCTTACCCCAACTCAATGACTTGGGGGTAAAGTTCTCTTCCTTTTGTTGCCTACCTCTTCCTCCACTCATTTGGGTTCAGAATAAACATGTCCTGAAGTTAAAGAGGAGTTAAGTCCTAAAGGAGGCATTTCTTCCCCACCTCCCTGACCTGGAACTCTGGCTACAGCCATTGTAGGAACTCCGTGCCTGGCCTGTCAGCTCCCTGCTAGGCTACAGTGGAATAGCAGAGCCCACAGGCTTCTCGTGGGGAGTTGGCTCCTTAACATTTCTTGGCAACAGAAAGCCCCAGGCACAGCTCAGGGAGGAGGGAAGGCAGGTAAGCTTTGGACGAGAACTGGCATATTTATTTTGACCCAAATCAGGGATTTCCCCAGTCCACCCAGTACTGGGCTCTTAAGCAAAAGTCTGAGAAACAAGACAGTGGTTTGAATTCTGGGGCCTTTGTGTAGGATTGTGCCTGACCTTTATTTATTTATTAACAGCAGGGCCACTCGTCTAGGGCAGTGGAGTCTGCGTGTCTCCTGGGGCTGGGGCAGGGCATTGGCAGTTACGCAGTGGCCCTGAACCTGGTCTGGTGCCCCCGAACCTGGTCTGATGCCCCCTCAGCTCTTTGACAATCACTGTGGCTGTTGGGTTTTCTCCTATTTCTAAAAATGTTCTCTTCTTTCCTAAGTGACAGTTTTGAAGTATTGGATAACCAAGAGCTCAGGTCACACAGACCTTGGAGCCCCATCTTTGCTTGCAGCTTAGCTTTGAGATACTAAGCAAGCGAGGGACTTCACTCTTGAGGCTGTTTTTTCCTCATCTGTAAAGTGGGGATAGTGGTACGGCCTACCTCATAGGGTTGTAATGAGCACTAAATGTGAAGTGCTTGGCACAGTGCCTGGCACATGGTGAGCCACAGCTACTGTGAGTTTCTGTTTATCCCCCTTTTTTTTTTTTAAGCCCATTGTTTATTCTTTGAGAATTTGTTGTAACTTCTTCAGGATAACACCTGAGTCCACAGGCTGAGCAGCTGTGGCCCAGACAGAACTGCTCCGGCTTGGCTGTTCCAGCAGGTGGGGCGCTGGCCTCGGTGAGGGCACAGCAGCAAGGTTCACGGATATCCGTGTGTCTTGTCTGTGGCCACCAGGCACAGGTTTGGCTTCCGGTCAGTGTCCCGACACTGTGCGGGAGGTGACAACAGAGCAAAGCAGCGCAGGGGTCAGGGAGGTACAGACACTGCTGAAATCACACTACCCCACCCTCAGCTGAAGCCCCACGTTCCACAAACTTGGGGTCATAGATTGTCCAGTCACTGGCTCCCTCCCTGTCAGCACAGCACAGAGGAAGGGGCTAACTGAATCTTTTACCACTTCTGGCCTGGCTCCAGAACTTTGTTCTAGATTCCTTAAAAGTCGGTAGCTGATGTCAAACTCAATTGAGCAGTAGCTTTGATCCCTTGGTCTGGGGGTCGAAGGAAGATGGTGCTGTTATCAGCGGGGAAATGTACTATTTAAGATCAGCTTTGTTGTAAAACCATTTGTTCTAGAATAAAACTCAATTGGAAACGTG
VastDB Features
Vast-tools module Information
Secondary ID
ENSG00000181026-AEN:NM_022767:3
Average complexity
IR-S
Mappability confidence:
NA
Protein Impact
Alternative protein isoforms
No structure available
Features
Disorder rate (Iupred):
C1=0.075 A=NA C2=0.590
Domain overlap (PFAM):
C1:
PF0092919=RNase_T=FE(42.3=100)
A:
NA
C2:
PF0092919=RNase_T=PD(11.5=22.8)
Main Inclusion Isoform:
NA
Other Inclusion Isoforms:
NA
Associated events
Other assemblies
Conservation
Zebrafish
(danRer10)
No conservation detected
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
CGGGATACGACCTATGTCCCA
R:
CGCCCCCTTCTCAATTCCTTC
Band lengths:
355-986
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Genotype-Tissue Expression Project (GTEx)
- Autistic and control brains
- Pre-implantation embryo development
Other AS DBs:
FasterDB (Includes CLIP-seq data)
AS-ALPS (AS-induced ALteration of Protein Structure, links to PINs)
APPRIS (Selection of principal isoform)
DEU primates (Only for human)