HsaINT0056577 @ hg19
Intron Retention
Gene
ENSG00000100393 | EP300
Description
E1A binding protein p300 [Source:HGNC Symbol;Acc:3373]
Coordinates
chr22:41537052-41542820:+
Coord C1 exon
chr22:41537052-41537226
Coord A exon
chr22:41537227-41542742
Coord C2 exon
chr22:41542743-41542820
Length
5516 bp
Sequences
Splice sites
5' ss Seq
CTAGTAAGT
5' ss Score
8.78
3' ss Seq
ATTTCTCTTTTTTACTCTAGATG
3' ss Score
10.1
Exon sequences
Seq C1 exon
GCGGAATACTACCACCTTCTAGCTGAGAAAATCTATAAGATCCAGAAAGAACTAGAAGAAAAACGAAGGACCAGACTACAGAAGCAGAACATGCTACCAAATGCTGCAGGCATGGTTCCAGTTTCCATGAATCCAGGGCCTAACATGGGACAGCCGCAACCAGGAATGACTTCTA
Seq A exon
GTAAGTGGTTTTTGTTATATTTCTGTTTGAGAGAAATTGATAATAAAATAGTTTCTATCTAAAGTCATTAATTTCTGTAAGCTTGTGTAACTATTCTAGAGTTTTTTAAATAACCATTTGCCTTTGCAAAGAAAATAACTCATCTACTAGTAAAAACAGAAGCAGAACAAGTATATTTAAGATGTCTGGGCATGGTACTTAACATACCTTGATAATCTGGAATTGTTTTTAGAGCCCAAGGTGTAAACTTCTCTAATAGTGACATCTAGAAAGCAATAGCCTACATACAGATGTTCACAGATTTCTCTGAGACTGGCTTGTGTGGTAAGTAGCCAGTAAATGTTTGTAGGCTGACCAGGTTCAGGAGCCCTGTAACACACATAATATCATATTACACTGTCACACTTTCTACTTGACATAAAATATTCTAAGTCTAGGAACTCTTTTTTTTTTTTTCTTTTTCTTTTTTTTTGAGGCAGAGTCTCACTCCGTCACCCAGGCTGGAGTACGGTGGCATGATCTTGGATCACTGCAGCCTCCGCCTCCCAGGTTCAAGCAATTCTCCCACCTCAGCCTTCCGAGTAGCTGGGATTACAGGCACATGCCACCACGCCTGTCTAATTTTTGTATTTTTCGTAGAGACAGGGTTTTGCCATGTTGGCCTAGCTGATCTCAAACTCCTGGCCTCAAATGATCCGCCCACCTTGGCATCCCAAAGTACTAGGATTACAGGCATGAGCCACCACTCCCTGCCTAGAAGCATCATTTAAAATTACATTTTGACAGCTTCAGTTTCTGATTATAGCATCATTGTTGACCTGATGAATTAACCAGATAGCCAAGACTATGATAAATAGTCTTACTCAATCGTTGACTTATTGGTACGATCAAAGTAGTGAAATATGGAGCAGGCACACCATTTTCAGGAATGGCACAGGCTGTAAGTGCTGTGAGCAAGGCTGTGATAGGAAAAACCTGCATTTACTGAGTTAGGAAATGCTAATGACCTCTAAGAAGTGCCAACTGAGCCAGCGGGCAGTAAACCTCATACGATCAGTAGATTATAGGTGGGCTGAGAAGTTCATCTCTTTCATTCATTGAAGTAGTAAAGTAGAGAACCATTGGTTACCACTGGCCTTTAGCAGCCTCATTTGCTAACTGAAGTGTGCCAGGTACTGTTTTGTAATGTGTAAAAAGTTGGGAGGAGCAACATTGCTGAGGAAATAGTATACATGGAGGCTGCCCAATAGTAAGGAAAAACACAGATTTTTTGAGTAGTTAGAACAAATTTTCAGGAATGAAAAAGTCAAGATTAGAGTTGAGACTGCTTCAGTACATGATTTGGACTTGAGTAGTAACTAAAGATTAAAAAAAGTAGACAGGCTGGGTGCGGTGGTTCATGCCTGTACTCCCAGCACTTTGGGAGGCCGAGGCGGGTAGATCATGACGTCAGGAGATGGAGACCATCCTGGCTAACACGGTGAAACCCCATCTCTACTAAAAATACAAAACAATTAGCCGGGCATGGTGGCGGGCACCTGTAGTCCCAGCTACTCAAGAGGCTGAGGCAGGAGAACAGTGTGAACCCGGGAGGCGGAGCTTGCAGTGAGCCGAGATTGTGCCTCTGCACTCCAGCCTGGGCAACAGAGCGAGACTCTGTCTCAAAAAAAAAACAAGTGGACATACCTGAGATACTTGGTTTTGGTAGAATTTACTCAAGTTCTGGGTGAAGTTCTGAGCCAAGTTTAAAGTCTGTGAGATATTAAATTGTATTCTAATGTCAGTATAAACAGTATGGTACTGATGTAAGCAGGAATAAGTGGTAGTGGAACTGAGTATCAGCCTTAAGTATATGTTGACCTTTAGCTCGTACTAAATCTGACATTTTGTAGAATGAGATTCTTACCTTAACCTGATACACAGAAAATAATAGAAGCATAAAAGTGGTCGGGCATGGTGGTGGCTCACGCCTGTAATCCCAGCTCTTTGGGAGGCTGAGGCTGCAGATCACTTGAGCTTAGGAGTTCAGAACCAGCCTGGGCAACATGGTGAAACTCTGTCTCTATAAAAAATACAAAAATTAGCCAGGCATGGAGGTGTGTGCCTGTAGTCCCAGCTACTCAGGAGGATGAGGCAGGAACATCACTTGAGCCCAGGAGGTCAAGGCTGCAGTGAGCTGTGATTGTGCCACTGCACTTAAGCCTGGACAACAGAGTGAGATCCTGTCTTTAAATAAATAAATAAGGTTTGTAAACTTTGAAAAAACAAAATTGAAAGAACTACGTAGAATGTTGAAGAAAACATAACATTCTCATCTTCATGTTTCTTTAACATTTGTTTTTTTGTTGTTGGTTTTGTTTTTGTTTTTTTTTTGAAACAGTCTCTCTTTGTCACTCAGGCTGAAGTGCAGTGGCACCATCTAAGCTCACTGCAACCTCTGCCTCCCAGATTCAGTTGATTCTTGTACCTCAGCATCCCCAGCAGCTGGAATTACAGGCATGCATCACCACACCTAACTAATGTTTTGTATTTTCAGTAGAGACAGGGTTTCACACCATGTTGGCCAACCTAGTCTCGAACTCCCGGCCTCAAGTGATCCGCGTACCTTGGTCTTGCAAAGTGCTGGGATTACAGGCTTGAGCCATCACACCTGGCCACGTTTGATTTTTTTGTTTTAATACAAAGAATACAGTTATTATAGAATCAGAGAGTGGCAATGGCAGGACTATGTGTATTGGCCTAAAAATATGCCCATAGTAAACTTATGTAACGTGTACCATCTTGAAAAAATAATCCCGGTTGTTAATGGAGTTGAAGGTAGGTAACTCTTTCCTTATTAATTTTTTGCAAAGATACGAAGTTTCAGGAAAAGCTGATGACAGAAGTATGCATGTTATAGTCTGAGTTTTTTTAAGTGTGGCATATGCCCTAGAAAAAGTTCTGGAAGAAGTAAATACTAATCTCTGAACATGGGCTTCTGATGGGGGCAGTGGAATTCCAGGATACTTGTGTTGTGTGATAAAGGGTTTTTGATTATTTGACTTAATGCATATAGTTTGCATTAAGGGCATATATATTGAAATGTGAAAGATGGACATTTTTGTTTGTGTATATTTTCTTTACCTCTAAATATTTATATATATACATTTTTGAGATGGGGTCTGTTTCGCCCAGCCTGGAGTGCAGTGGTGTGATCTCGGCTCACTGCATCCTCCATGCCTCCCAAGCTCAAGCAATCCTCCCACTTCAGCCCCCCAAGTAGCTGGGACCACAGGCACACGCCACCATGCCTGGCTAATTTTTTTTTATTTTTTAGTAGAAACAGGGTTTCTGTATGTTGCCCAGACTAGTCTCGAACTCCTGAGCTCAAGATATCCACCCACCTCGGCCTCCCAAAATGCTGAAATTACAGGTGTGACCCACTGCGCCCAGCCTTTAAATATTTATCTTAAAAAATAGTATCAAGATGTTCCTTTAAATAATTCATCAAGTTTCCTTAAAATGACAAGAGCTGCCTCATGGAGCAATAATAGATACATTCGTATCTGCATCATATGGGGCAAATGTGGGCAGTAGGATTGCGGTTTTATTTTTAAACCATTTTCATTTGATTAGTCTCAAATACTTAAAAATCAGAAGATTTTGCATTTAAAAAGTCTGAATTTCTGGCTGCTTTAAAAAAAAAAGGACATGTCTGGCAGACTTGACCCCCTTTCTCCTACAGTGACACCTGTCTATAGCTGCACTCATGGCTGACTCTAGAAGAGCTGTGTTTTCTCTCCACTTCAGTCCTCACCATTCTCTATTGTTTTGGGTACTTAAAACAGTTTTACTTGGTATTAGCTGCTTGGCACTTGCCATTTAGCTTGGAACACCTATCCATATTGTTGACTTGAAAAAAAAGTTACTCATATCTTAGGTGAAAACATTGTTTTGTAGATAGTGTGCGTGAATACAGATATGTGTGGGGAGGAAGAGGAAAGGTTTATCTCAAGGTCATTTGTTGGATCCTGATTCATTTTTCTATTGATTTTTAATTTTTATGTAATGAGCATGGATTATGCATATACTTCTTATAAAGCTTGCAGAGTTACAGATAAAAGTTTATATGAATAAATGTTGAGCATTTCCTCTCTCAGTTTTGCTCATTTACTAAAGGTTGAAATTTGTCTGAAGGGATGGACATCTCCTTAGAAGAGCAGCAGGTCTTCCTCTCCTATGCCTGAGGCTTGAATGTACAGCCCTTGATGGAGGGTATGGCCAGGGTGGAGCCAGGTCACTACAGACATCTGTCCTTTCCGAGGGTGCTGTAAAAATATTTTCTCTGTGCACTATGTTGAAAGTACTACACTAGAGCATGTGCAGATAATCCAGGAAAAAGACCTTAGAATTTATGTATTTATATTTTAGGTTTTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCACGATCTCAGCTTACTGCAAGCTCCACCTCCCGGGGTCATGCCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCGCCTGCCACCACGCCCGGCTATTTTTTTGTATTTTTAGTAGAGACGGGTTTCACCGTGCTATCTAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGATATTTTATTTTTTTAAGAATTATTTCTGTTTTTGTATTTAAGAGGTACATGATATGTAGTGTGGTATAATATGCATATTATTTAAAATCAATGTTCACAGTTTATGTGCATAAAAACGTTGTGCTACATGATCAAATTCGGCCACCATTAGACATGATTCATAGCTATTATCCATGGAGATACTCTGTTGCATGCCAACCAGACTCAGACTTTGTTAAACAATAACATATTAAATGCTATGATGGCCTCAATTTTTTTTTTTTTTTTTGAGACAGAGTCTTGCTCCATCGCCCAGGCTGGAGTGCAGTCGTGTGATCTTGGCTCACTGCAACCTCCGCCTTCCAGGTTCATGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGTGCCTGCCACCACGCCTGGCTAATTTTTTTGTATTTTTAGTAGAGACAGGGTTTCGCCATGTTGGCTAGGCTGGTTTTGAACTCCTGACCTCAAGTGATCCACCCACCTCAGCCTCCCAAAGTGCCAGGATTACAGGCGTGAGCCACTGTGCCTGGCCTATAATGGCTTCAATAGCTTATTTTTCTATCAACATTGAAAGCACCCGGGCTCATAAAGGAATACCAACAAATCCACTTGGAGGCATTTTTCTGTATTCCAGAAATAACATTTTCTTCAAGCTTCTGTCTAGTTCAGAGCTTTATTTTGTGATTCATACTCAATTTTCAAAGGTATTATTAAAAATATTTTGTGGGGTTTGTGTGTGCAGTGAGTTTTTGTTTGGTTAAGGGAAGATGGTGCAAAGATACTTATTTCTCTTTTTTACTCTAG
Seq C2 exon
ATGGCCCTCTACCTGACCCAAGTATGATCCGTGGCAGTGTGCCAAACCAGATGATGCCTCGAATAACTCCACAATCTG
VastDB Features
Vast-tools module Information
Secondary ID
ENSG00000100393-EP300:NM_001429:10
Average complexity
IR-S
Mappability confidence:
NA
Protein Impact
ORF disruption upon sequence inclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.734 A=NA C2=0.915
Domain overlap (PFAM):
C1:
PF0217211=KIX=PD(23.5=32.2),PF068866=TPX2=PD(81.6=52.5)
A:
NA
C2:
PF139001=GVQW=PD(10.0=66.7)
Main Inclusion Isoform:
NA
Associated events
Other assemblies
Conservation
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
No suggested primer sequences
R:
No suggested primer sequences
Band lengths:
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Autistic and control brains
- Pre-implantation embryo development
Other AS DBs:
FasterDB (Includes CLIP-seq data)
AS-ALPS (AS-induced ALteration of Protein Structure, links to PINs)
APPRIS (Selection of principal isoform)
DEU primates (Only for human)