HsaINT0107853 @ hg19
Intron Retention
Gene
ENSG00000092054 | MYH7
Description
myosin, heavy chain 7, cardiac muscle, beta [Source:HGNC Symbol;Acc:7577]
Coordinates
chr14:23890167-23891534:-
Coord C1 exon
chr14:23891389-23891534
Coord A exon
chr14:23890258-23891388
Coord C2 exon
chr14:23890167-23890257
Length
1131 bp
Sequences
Splice sites
5' ss Seq
AAAGTACTG
5' ss Score
-0.75
3' ss Seq
CCATCCCTCCTTCCCCACAGAAA
3' ss Score
11.17
Exon sequences
Seq C1 exon
CTGGAAGGATCCCTGGAGCAAGAGAAGAAGGTGCGCATGGACCTGGAGCGAGCGAAGCGGAAGCTGGAGGGCGACCTGAAGCTGACCCAGGAGAGCATCATGGACCTGGAGAATGACAAGCAGCAGCTGGATGAGCGGCTGAAAAA
Seq A exon
GTACTGTGTCCCCTCCCTGCTGCCCTTCCTCCTCCCCAGCCCATAACAGTACAAGCAGACCCAAGACAGCCATCCTCTGAGGCAACAACCTCACGCAGCCTCCACAAGTGGAGGCGCAAACCATGGGAAAAGGCCTCCCAGGCAAGGGCTTTCCTCCCCTAGTCCCAGATATCAGGGTTAGTTAGATGGTCCTCCCTGGCAAAAAGTCCATTGTATCCCATGAGTCCTTTCTTCTTGTTAGGCACTCAGTGGGAATGAAAATAACAGCCTTCCCCCTTCATACACATCTCTCTTTGGAGACCAGTTCCTTGACATGGAGGAAGGCTCCACATGAGAGCCTCTTAGGAAAGTCCCTTTGTGGCTTTTCACAGAGAGCCCACAGGGCACCAAGAAATGCCCTCACATTAAAGAAGTCAGGGGATCAGGGCCATTTCTTTGTTTTGCTTAACTTGTGGTTCCAATTCTTAGTGTAAGTTCTTCCAAAATGTATAGACTTTCCAGACTTGGTAAACAGTGAGCTTGCAGAACATATTTTGATAATTGAAGGTCTTATGGTGTTTCAGGCTCAGGACTTTGAAAGGCTTTGAGAATCATCATAATCTACATCCTCATCAAGTTTGTGTTTGCACAGGAATCTTCATACCTTCCCAGGCACAGAATGTGTTGAATAAATGAATAAATACACGATCCTATTTGATTCTCAAAACACCTTTTAAGGATGGTATCTTTAATTTCACTTTACCAAAGAGGAAAATAAGTTTCAGAAAGGTTAGCTGAGTTACCCAAAGCAATAGTGACAAAATTAAAGACCATCAGAGCTAAAAAGGACCTTTGAAACAATCTAGTCCGACCCCCTCATTTTACATTATGAGAAAACAAGGACCAAAGATGGGAATGTCCTGTAGAGCCCAGGCCCCATCACCCTGTCTACAGCACTCCTCCCATTACATTCTTGTTGGATTTCAATCTCACCGCAGGTGTTACACTTCCAGGGATCCTACATCACCCCCAGAAGCTGTTTTTCTAATGAAATCCTACTCTTTACCTGTATCATTACCATTTTCAACCACTGGTGGACCCTCCTGAGGCCCCACGAGTCTCCCTTACCTCACCATCCCTCCTTCCCCACAG
Seq C2 exon
AAAAGACTTTGAGCTGAATGCTCTCAACGCAAGGATTGAGGATGAACAGGCCCTCGGCAGCCAGCTGCAGAAGAAGCTCAAGGAGCTTCAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSG00000092054-MYH7:NM_000257:25
Average complexity
IR-S
Mappability confidence:
NA
Protein Impact
ORF disruption upon sequence inclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.449 A=NA C2=0.032
Domain overlap (PFAM):
C1:
PF0157614=Myosin_tail_1=PD(26.4=69.4),PF0003816=Filament=FE(17.0=100),PF0157614=Myosin_tail_1=PU(1.6=28.6)
A:
NA
C2:
PF0003816=Filament=FE(10.6=100),PF0157614=Myosin_tail_1=FE(3.5=100)
Main Inclusion Isoform:
NA
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
NA
Associated events
Other assemblies
Conservation
Zebrafish
(danRer10)
No conservation detected
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
CTGGAAGGATCCCTGGAGCAA
R:
TCCTTGAGCTTCTTCTGCAGC
Band lengths:
230-1361
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Autistic and control brains
- Pre-implantation embryo development
Other AS DBs:
FasterDB (Includes CLIP-seq data)
AS-ALPS (AS-induced ALteration of Protein Structure, links to PINs)
APPRIS (Selection of principal isoform)
DEU primates (Only for human)