HsaINT0176823 @ hg19
Intron Retention
Gene
ENSG00000144357 | UBR3
Description
ubiquitin protein ligase E3 component n-recognin 3 (putative) [Source:HGNC Symbol;Acc:30467]
Coordinates
chr2:170863500-170865450:+
Coord C1 exon
chr2:170863500-170863700
Coord A exon
chr2:170863701-170865313
Coord C2 exon
chr2:170865314-170865450
Length
1613 bp
Sequences
Splice sites
5' ss Seq
CCAGTAAGC
5' ss Score
5.34
3' ss Seq
ATGTTTGCATTTTTTTATAGTCA
3' ss Score
7.09
Exon sequences
Seq C1 exon
AATGACCAGGTTCTTCAGGGCTTCTCGGTGGACAAAGGAGAATTCACGTGTCCACTCTGTAGGCAGTTTGCTAACAGTGTTCTTCCATGTTATCCTGGAAGCAATGTGGAAAATAACCCTTGGCAACGTCCTAGCAACAAAAGCATACAAGATCTCATAAAGGAAGTGGAGGAGCTGCAGGGACGACCGGGAGCTTTCCCA
Seq A exon
GTAAGCATCAGTGTAAGGCATAAATATCCTGGTTAACTCAGCTCTGATTTTCTGCTTTCATTTTAATTCAGTTTATAAATTACTCTGGACTTTTACATATTTAGTAGAAATTGCTTTTAGAGGTTTTGTTCTCTTCTATTTATACTTAAATAAAAGTAATAGAACAAATTATTATCAAAGGCTATACTTCTCTTTAGGCTAAATTCTGAGTTTTAATATACGTCTTCTAGGTCAAGAACCCCTATAGGTTTAGATGGAGTTAGCCTCTTTTAAGATGTTCAAATAGGCCAGGCACGGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGACAGATAACTTAAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGCAAAACCCCGTCTCTACTAAAAATACAAAAATTAGCCAGGCGTGGTGGCGCTGAGACAGACAGATCACTTAAGGTCAGGAGTTTGAAACCAGCCTGACCAACATGGCAAAACCGCATCTCTACTAAAAATACAAAAATTGGCCGGGCACAGTGGCACACACATGTAATCCCAGCTACACGGGAGGCTGAGGCAGGAGAATTGCTTAAACCCAGGAGCCGGAGGTTGCAGGGAGCTGGGATCGTGCCACTCCACTCCAGTCTAGGCAGCAGAGCGAGACTCCCTCTCAAAATAAAAAAGATGTTGAATTATTTAAAAAACAAGCTATATATACTCTGTGTGTGTGTGTGTGTGTATGTATCTCAATATAAAACACAATTTAATCACTTAAAAATATGCCCATTAGGTATATTAGGATTAAGAAGATATATTTACACAGACATGCACATGTATTTACTGTGTGTATGTGTATTCGAGAGATAAAATATTGTGTAATTGATTGAACTGTTCATCACAAGTCAGACTACTGTAGGGGGGAACTCATCTTTTATCCCATCCAGTAGGATTTGTTTGGTCTAAATTCTTAAAATATTTCACCTTCATAAAAAAAAATTTCACCTTCATTATAGATTTGTGATATGGTCTCTGAGAGAAGTGACAGCTGTGTCTGGTTTATGTAGTAAATTTGTGAAAATTGTGAATATTTGACTTTTGAAACAGAAATGCATACTTTAAACCTAGATAGATTCATCTGGCAATTCCCTTTCTCAAGCGAAGACTAATTTTAGAATTTGTGGTCTTTTTAAAATTTTATAAATCCAAATTCTTATGTGTTTAAAATATGCTTAAACTTACGGGACATTGATATTATTCTTTGAAAAATGAACTTAAATGAAAGTCAGGTTTTTTATAGACATGGAAACTTTGTTCTAACATATTATTTTAATACCATCATCTCATTGGCTTAGCATAATTTATGTGGTTAATTCATAGTTGGATTACAGTGTTACCAGTCACAATGTAGAATTAGAATAAAAGATCACTGTTTAGAGAGTATTTTTTGATTGGTTTAACTTTGTACACTAAATATATTTATAATAGATAATGTTCTGTTTTGACTTTTTAATTTTAATTTCCTACTATGTTCATATAATAAACATTCTAGTTTCAGACCATTATTAAAGAAAGTGAATATAAACTTTATATGTATGTTTGCATTTTTTTATAG
Seq C2 exon
TCAGAAACAAATTTAAGTAAAGAAATGGAATCTGTAATGAAAGATATAAAAAATACCACTCAGAAGAAATATAGAGACTATAGCAAGACCCCGGGCTCACCAGACAATGATTTTCTCTTTATGTACTCTGTTGCTAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSG00000144357-UBR3:NM_172070:28
Average complexity
IR-S
Mappability confidence:
NA
Protein Impact
ORF disruption upon sequence inclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.142 A=NA C2=0.365
Domain overlap (PFAM):
C1:
PF136391=zf-RING_2=PD(35.1=29.9),PF0080420=Syntaxin=PU(47.1=35.8)
A:
NA
C2:
PF0080420=Syntaxin=PD(49.0=54.3)
Main Inclusion Isoform:
NA
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
Associated events
Other assemblies
Conservation
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
ATGACCAGGTTCTTCAGGGCT
R:
AGCAACAGAGTACATAAAGAGAAAAT
Band lengths:
335-1948
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Autistic and control brains
Other AS DBs:
FasterDB (Includes CLIP-seq data)
AS-ALPS (AS-induced ALteration of Protein Structure, links to PINs)
APPRIS (Selection of principal isoform)
DEU primates (Only for human)