Special

MmuEX0015287 @ mm9

Exon Skipping

Gene
ENSMUSG00000026825 | Dnm1
Description
dynamin 1 [Source:MGI Symbol;Acc:MGI:107384]
Coordinates
chr2:32163991-32167862:-
Coord C1 exon
chr2:32167647-32167862
Coord A exon
chr2:32165971-32166007
Coord C2 exon
chr2:32163991-32164584
Length
37 bp
Sequences
Splice sites
3' ss Seq
GATTTCGTGCTGTCTTTCAGAAT
3' ss Score
9.63
5' ss Seq
ACGGTAGGT
5' ss Score
10.15
Exon sequences
Seq C1 exon
ATCGCCCACGTCCAGCCCCACGCCGCAGCGCCGAGCCCCCGCCGTGCCCCCAGCCCGGCCCGGATCGCGGGGCCCTGCTCCTGGGCCTCCGCCTGCTGGATCCGCCCTGGGGGGGGCGCCCCCCGTGCCCTCCAGGCCGGGGGCTTCCCCTGACCCCTTTGGCCCCCCTCCCCAGGTGCCCTCGCGCCCCAACCGCGCCCCGCCTGGGGTCCCCAG
Seq A exon
AATCACTATCAGTGACCCCTGAGGAGTGTCAGCTACG
Seq C2 exon
CCGATCGGGTCAGGCAAGTCCGTCCCGTCCTGAGAGCCCCAGGCCCCCCTTCGACCTCTAACCAGATCCCTCCTACTCCTCGGAGACCTCCCTTACCAAGCCTGCCTGGACAGCTGTTCTGTGACTTGACAGTGGCTCCCCCGGCCCCAAAGCGTCCTATTCATCATCTGTGACTTAGTCTGTTGTAGTGGTGAGCTGACACATCCAGATGTGATGTTGGTGAAAACTTGTGCCCCTCTGTGGTATTGCTCCTGCGACATTCTATAAATATCTATAAATATACCTATATATACATATATATACATATATATGGCTGACACAGCCTCGCCTGTAGTGTCAGAATCAACCACCATGCTGTCCTTGTGGAGTCTTGTGGTCCAACAAGGGAACGCTGTCATCCTGACAACCCCCCCTCCAGTGTACCACCTCCAGTGAGCCCCCCTGTCCTCCTGGCCTGTGAACAGCCATCCCCTTGGCCATCCCAACCCTGCAGCAAGGGG
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000026825_MULTIEX1-1/2=C1-C2
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact





	

	
ORF disruption upon sequence inclusion





No structure available

		

			
Features


			

				
Disorder rate (Iupred):
  C1=0.965 A=1.000 C2=1.000
 
                        

				
Domain overlap (PFAM):

					





						

							
C1:
NO

							
A:
NO

							
C2:
NO

						

					

				








    
Main Inclusion Isoform:
ENSMUSP00000077461





     
                   









    
Main Skipping Isoform:
ENSMUSP00000108992





     
      









    
Other Inclusion Isoforms:
ENSMUSP00000108977, ENSMUSP00000108979, ENSMUSP00000108981, ENSMUSP00000115523, ENSMUSP00000116054
          









    
Other Skipping Isoforms:
ENSMUSP00000088618
  



Associated events







Other assemblies


mm10




Conservation


Human
(hg38)
chr9:128253101-128253137 
ALTERNATIVE
HsaEX0020437
(DNM1)
Human
(hg19)
chr9:131015380-131015416 
ALTERNATIVE
HsaEX0020437
(DNM1)
Rat
(rn6)
chr3:11340145-11340181 
ALTERNATIVE
RnoEX0029037
(Dnm1)
Cow
(bosTau6)
chr11:98875740-98875776 
ALTERNATIVE
BtaEX0011730
(DNM1)
Chicken
(galGal4)
chr17:5021838-5021874 
ALTERNATIVE
GgaEX0006670
(DNM1)
Chicken
(galGal3)
chr17:5654437-5654473 
ALTERNATIVE
GgaEX0006670
(E1BV15_CHICK)
Zebrafish
(danRer10)
chr5:1358592-1358628 
ALTERNATIVE
DreEX0027748
(dnm1a)
Fruitfly
(dm6)
No conservation detected




Primers PCR

	

		

			
Suggestions for RT-PCR validation

			

				
F: 
GGCTTCCCCTGACCCCTTT

				
R: 
GGGCTCTCAGGACGGGAC

				
Band lengths: 
114-151

			

		

	





	
Functional annotations
(Submit an annotation)

	


There are 1 annotated functions for this event 


PMID: 21689596
HsaEX0020437
Partially encodes an experimentally validated Eukaryotic Linear Motif (ELM). Method: competition binding, glutathione s tranferase tag, mutation analysis, pull down. ELM ID: ELMI002614; ELM sequence: VPRITIS; Overlap: PARTIAL_LEFT


		










GENOMIC CONTEXT[edit]












INCLUSION PATTERN[edit]






SPECIAL DATASETS
  • Pre-implantation embryo development
  • Neural differentiation time course
  • Muscular differentiation time course
  • Spermatogenesis cell types
  • Reprogramming of fibroblasts to iPSCs
  • Hematopoietic precursors and cell types






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