Special

MmuEX0019435 @ mm10

Exon Skipping

Gene
ENSMUSG00000075415 | Fnbp1
Description
formin binding protein 1 [Source:MGI Symbol;Acc:MGI:109606]
Coordinates
chr2:31036542-31040514:-
Coord C1 exon
chr2:31040405-31040514
Coord A exon
chr2:31037156-31037288
Coord C2 exon
chr2:31036542-31036663
Length
133 bp
Sequences
Splice sites
3' ss Seq
TCTTGTTATCCCTTTCTCAGAGA
3' ss Score
8.87
5' ss Seq
GAGGTGTGG
5' ss Score
4.48
Exon sequences
Seq C1 exon
GGTGTCACACCAGAAGACTTCAGCAACTTCCCACCTGAGCAGAGAAGGAAAAAACTACAACAGAAAGTTGACGATCTCAATAGAGAGATACAGAAGGAGACGGACCAGAG
Seq A exon
AGATGCCATCACCAAAATGAAAGATGTGTACCTAAAGAACCCTCAGATGGGAGACCCAGCCAGCCTGGACCAGAAGCTCACCGAAGTCACCCAGAACATAGAGAAACTGCGGCTGGAGGCTCAGAAGTTTGAG
Seq C2 exon
GCCTGGCTGGCTGAGGTAGAAGGCAGACTCCCAGCTCGGAGTGAGCAGGCACGCCGGCAGAGTGGACTGTATGATGGCCAGACACACCAGACGGTCACTAACTGTGCCCAGGACCGGGAGAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000075415-'57-49,'57-47,59-49=AN
Average complexity
A_S
Mappability confidence:
100%=100=100%
Protein Impact





	

	
ORF disruption upon sequence exclusion





Show structural model

		

			
Features


			

				
Disorder rate (Iupred):
  C1=0.933 A=0.699 C2=0.779
 
                        

				
Domain overlap (PFAM):

					





						

							
C1:
PF104814=CENP-F_N=FE(24.7=100),PF143891=Lzipper-MIP1=PU(32.5=73.0),PF154561=Uds1=PU(29.6=64.9),PF0218511=HR1=PU(24.2=40.5)

							
A:
PF104814=CENP-F_N=PD(21.9=71.1),PF143891=Lzipper-MIP1=FE(53.0=100),PF154561=Uds1=FE(54.3=100),PF0218511=HR1=FE(71.0=100)

							
C2:
PF143891=Lzipper-MIP1=PD(10.8=22.0),PF154561=Uds1=PD(12.3=24.4),PF0218511=HR1=PD(0.1=0.0)

						

					

				








    
Main Inclusion Isoform:
ENSMUSP00000109190





     
                   









    
Main Skipping Isoform:
NA





     
      









    
Other Inclusion Isoforms:
ENSMUSP00000074796, ENSMUSP00000097781, ENSMUSP00000097782, ENSMUSP00000109184, ENSMUSP00000109188, ENSMUSP00000109189, ENSMUSP00000109192, ENSMUSP00000109194, ENSMUSP00000115013, ENSMUSP00000141681
          









    
Other Skipping Isoforms:
NA
  



Associated events






Other assemblies


mm9




Conservation


Human
(hg38)
chr9:129902869-129903001 
HIGH PSI
HsaEX0026110
(FNBP1)
Human
(hg19)
chr9:132665148-132665280 
HIGH PSI
HsaEX0026110
(FNBP1)
Rat
(rn6)
chr3:9869345-9869477 
HIGH PSI
RnoEX0036512
(Fnbp1)
Cow
(bosTau6)
chr11:100298314-100298446 
HIGH PSI
BtaEX6046673
(FNBP1)
Chicken
(galGal4)
chr17:5741199-5741331 
HIGH PSI
GgaEX6015183
(FNBP1)
Chicken
(galGal3)
chr17:6297918-6298050 
HIGH PSI
GgaEX6015183
(FNBP1)
Zebrafish
(danRer10)
chr21:6269976-6270108 
HIGH PSI
DreEX6083062
(fnbp1b)
Fruitfly
(dm6)
No conservation detected




Primers PCR

	

		

			
Suggestions for RT-PCR validation

			

				
F: 
GTGTCACACCAGAAGACTTCAGC

				
R: 
CCGGTCCTGGGCACAGTTAG

				
Band lengths: 
226-359

			

		

	





	
Functional annotations
(Submit an annotation)

	


There are 0 annotated functions for this event 


		










GENOMIC CONTEXT[edit]












INCLUSION PATTERN[edit]






SPECIAL DATASETS
  • Pre-implantation embryo development
  • Ribosome-engaged transcriptomes of neuronal types
  • Neural differentiation time course
  • Muscular differentiation time course
  • Spermatogenesis cell types
  • Reprogramming of fibroblasts to iPSCs
  • Hematopoietic precursors and cell types





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