Special

MmuEX0024722 @ mm9

Exon Skipping

Gene
ENSMUSG00000030102 | Itpr1
Description
inositol 1,4,5-trisphosphate receptor 1 [Source:MGI Symbol;Acc:MGI:96623]
Coordinates
chr6:108186972-108289616:+
Coord C1 exon
chr6:108186972-108187079
Coord A exon
chr6:108191258-108191328
Coord C2 exon
chr6:108289501-108289616
Length
71 bp
Sequences
Splice sites
3' ss Seq
ATTTGTTTTTCTTTTTGCAGCTT
3' ss Score
10.59
5' ss Seq
GAGGTAAAG
5' ss Score
8.27
Exon sequences
Seq C1 exon
GCTTTCCAACACGGACATGTCTGACAAAATGTCGAGTTTCCTACATATTGGAGACATTTGTTCTCTGTATGCGGAGGGATCTACGAATGGATTTATCAGCACCTTAGG
Seq A exon
CTTGGTTGATGACCGTTGTGTTGTACAGCCAGAAGCCGGGGACCTTAACAATCCACCCAAGAAATTCAGAG
Seq C2 exon
ACTGCCTCTTTAAGCTATGTCCTATGAATCGATACTCCGCACAGAAACAGTTCTGGAAAGCTGCTAAGCCCGGGGCCAACAGCACTACAGATGCAGTGCTGCTCAACAAATTGCAT
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000030102-'3-6,'3-2,4-6
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact





	

	
ORF disruption upon sequence exclusion





No structure available

		

			
Features


			

				
Disorder rate (Iupred):
  C1=0.000 A=0.000 C2=0.000
 
                        

				
Domain overlap (PFAM):

					





						

							
C1:
PF087096=Ins145_P3_rec=PU(11.9=87.1)

							
A:
PF087096=Ins145_P3_rec=FE(10.6=100)

							
C2:
PF087096=Ins145_P3_rec=FE(16.8=100)

						

					

				








    
Main Inclusion Isoform:
ENSMUSP00000032192





     
                   









    
Main Skipping Isoform:
ENSMUSP00000127802





     
      









    
Other Inclusion Isoforms:
ENSMUSP00000032192f2673A, ENSMUSP00000032192f2674A, ENSMUSP00000108830, ENSMUSP00000108833, ENSMUSP00000108834, ENSMUSP00000130211
          









    
Other Skipping Isoforms:
NA
  



Associated events







Other assemblies


mm10




Conservation


Human
(hg38)
chr3:4521024-4521094 
HIGH PSI
HsaEX0032562
(ITPR1)
Human
(hg19)
chr3:4562708-4562778 
HIGH PSI
HsaEX0032562
(ITPR1)
Rat
(rn6)
chr4:140272570-140272640 
HIGH PSI
RnoEX6014546
(Itpr1)
Cow
(bosTau6)
chr22:21938581-21938651 
Chicken
(galGal4)
chr12:18402504-18402574 
HIGH PSI
GgaEX1030849
(ITPR1)
Chicken
(galGal3)
chr12:19046140-19046210 
HIGH PSI
GgaEX1030849
(Q9DEX2_CHICK)
Zebrafish
(danRer10)
chr6:39935557-39935627 
HIGH PSI
DreEX6023201
(itpr1a)
Fruitfly
(dm6)
No conservation detected




Primers PCR

	

		

			
Suggestions for RT-PCR validation

			

				
F: 
CCAACACGGACATGTCTGACA

				
R: 
GGGCTTAGCAGCTTTCCAGAA

				
Band lengths: 
174-245

			

		

	





	
Functional annotations
(Submit an annotation)

	


There are 1 annotated functions for this event 


PMID: 9808459
HsaEX0032562
Encodes an experimentally validated Eukaryotic Linear Motif (ELM). Method: western blot. ELM ID: ELMI001694; ELM sequence: PPKKF; Overlap: FULL


		










GENOMIC CONTEXT[edit]












INCLUSION PATTERN[edit]






SPECIAL DATASETS
  • Pre-implantation embryo development
  • Neural differentiation time course
  • Muscular differentiation time course
  • Spermatogenesis cell types
  • Reprogramming of fibroblasts to iPSCs
  • Hematopoietic precursors and cell types






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