Special

MmuEX0051296 @ mm9

Exon Skipping

Gene
ENSMUSG00000033721 | Vav3
Description
vav 3 oncogene [Source:MGI Symbol;Acc:MGI:1888518]
Coordinates
chr3:109366022-109431085:+
Coord C1 exon
chr3:109366022-109366122
Coord A exon
chr3:109381237-109381282
Coord C2 exon
chr3:109430949-109431085
Length
46 bp
Sequences
Splice sites
3' ss Seq
TTGCTTTGTTTTTCTTACAGAAA
3' ss Score
10.41
5' ss Seq
CAGGTCTGT
5' ss Score
6.84
Exon sequences
Seq C1 exon
GGGAACATTTTATCAAGGCTACTTATGTTTTAAGTGTGGAGCAAAAGCACATAAAGAATGTTTGGGAAGAGTAGACAATTGTGGCAGAGTTAATTCCGTTG
Seq A exon
AAACGGACCAATGGACTTCGGAGAGCTTCCAGACAGGTGGACCCAG
Seq C2 exon
GTTTGCCGAAGATGCAGGTCATTAGGAACTACACTGGCACCCCGGCCCCAGGGCTTCATGAAGGACCACCATTGCATATCCAGGCAGGCGACACTGTTGAACTTCTGAGAGGAGATGCACACAGTGTGTTCTGGCAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000033721_MULTIEX1-2/2=C1-C2
Average complexity
C2
Mappability confidence:
100%=100=100%
Protein Impact





	

	
ORF disruption upon sequence exclusion





No structure available

		

			
Features


			

				
Disorder rate (Iupred):
  C1=0.086 A=0.875 C2=0.478
 
                        

				
Domain overlap (PFAM):

					





						

							
C1:
PF0013017=C1_1=PD(58.5=88.6),PF0063014=Filamin=FE(14.0=100)

							
A:
PF0063014=Filamin=PU(6.5=56.2)

							
C2:
PF0765312=SH3_2=PU(66.7=91.3),PF0063014=Filamin=FE(18.6=100)

						

					

				








    
Main Inclusion Isoform:
ENSMUSP00000036270





     
                   









    
Main Skipping Isoform:
NA





     
      









    
Other Inclusion Isoforms:
ENSMUSP00000102186, ENSMUSP00000132280
          









    
Other Skipping Isoforms:
NA
  



Associated events







Other assemblies


mm10




Conservation


Human
(hg38)
chr1:107683488-107683533 
ALTERNATIVE
HsaEX0070272
(VAV3)
Human
(hg19)
chr1:108226110-108226155 
ALTERNATIVE
HsaEX0070272
(VAV3)
Rat
(rn6)
chr2:212487509-212487554 
HIGH PSI
RnoEX6011166
(Vav3)
Cow
(bosTau6)
chr3:35721844-35721889 
HIGH PSI
BtaEX6016212
(VAV3)
Chicken
(galGal4)
chr8:1033880-1033925 
HIGH PSI
GgaEX1062994
(VAV3)
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
chr2:16382769-16382802 
HIGH PSI
DreEX6026193
(vav3b)
Fruitfly
(dm6)
No conservation detected




Primers PCR

	

		

			
Suggestions for RT-PCR validation

			

				
F: 
AAGTGTGGAGCAAAAGCACAT

				
R: 
GTGGTCCTTCATGAAGCCCTG

				
Band lengths: 
139-185

			

		

	





	
Functional annotations
(Submit an annotation)

	


There are 0 annotated functions for this event 


		










GENOMIC CONTEXT[edit]












INCLUSION PATTERN[edit]






SPECIAL DATASETS
  • Pre-implantation embryo development
  • Neural differentiation time course
  • Muscular differentiation time course
  • Spermatogenesis cell types
  • Reprogramming of fibroblasts to iPSCs
  • Hematopoietic precursors and cell types






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