Special

MmuEX6069904 @ mm10

Exon Skipping

Gene
ENSMUSG00000006932 | Ctnnb1
Description
catenin (cadherin associated protein), beta 1 [Source:MGI Symbol;Acc:MGI:88276]
Coordinates
chr9:120957517-120958652:+
Coord C1 exon
chr9:120957517-120957667
Coord A exon
chr9:120957759-120957880
Coord C2 exon
chr9:120958592-120958652
Length
122 bp
Sequences
Splice sites
3' ss Seq
AGTTTCTTTTTTTATTCCAGCAA
3' ss Score
7.1
5' ss Seq
GAGGTAGGC
5' ss Score
8.99
Exon sequences
Seq C1 exon
TTGCTTTATTCTCCCATTGAAAATATCCAAAGAGTAGCTGCAGGGGTCCTCTGTGAACTTGCTCAGGACAAGGAGGCTGCAGAGGCCATTGAAGCTGAGGGAGCCACAGCTCCCCTGACAGAGTTACTCCACTCCAGGAATGAAGGCGTGG
Seq A exon
CAACATACGCAGCTGCTGTCCTATTCCGAATGTCTGAGGACAAGCCACAGGATTACAAGAAGCGGCTTTCAGTCGAGCTGACCAGTTCCCTCTTCAGGACAGAGCCAATGGCTTGGAATGAG
Seq C2 exon
ACTGCAGATCTTGGACTGGACATTGGTGCCCAGGGAGAAGCCCTTGGATATCGCCAGGATG
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000006932-'58-49,'58-42,62-49=AN
Average complexity
A_S
Mappability confidence:
NA
Protein Impact





	

	
ORF disruption upon sequence exclusion





No structure available

		

			
Features


			

				
Disorder rate (Iupred):
  C1=0.081 A=0.016 C2=0.213
 
                        

				
Domain overlap (PFAM):

					





						

							
C1:
PF0051418=Arm=PD(53.7=43.1),PF0051418=Arm=PU(65.9=52.9)

							
A:
PF0051418=Arm=PD(29.3=29.3)

							
C2:
NO

						

					

				








    
Main Inclusion Isoform:
ENSMUSP00000007130





     
                   









    
Main Skipping Isoform:
NA





     
      









    
Other Inclusion Isoforms:
ENSMUSP00000128564, ENSMUSP00000136294
          









    
Other Skipping Isoforms:
NA
  



Associated events







Other assemblies


mm9




Conservation


Human
(hg38)
chr3:41236588-41236709 
HIGH PSI
HsaEX6055279
(CTNNB1)
Human
(hg19)
chr3:41278079-41278200 
HIGH PSI
HsaEX6055279
(CTNNB1)
Rat
(rn6)
chr8:129625694-129625815 
HIGH PSI
RnoEX6038292
(Ctnnb1)
Cow
(bosTau6)
chr22:13886162-13886283 
HIGH PSI
BtaEX6093577
(CTNNB1)
Chicken
(galGal4)
chr2:44044577-44044698 
HIGH PSI
GgaEX6019675
(CTNNB1)
Chicken
(galGal3)
chr2:43476804-43476925 
HIGH PSI
GgaEX6019675
(CTNNB1)
Zebrafish
(danRer10)
chr16:6285008-6285129 
HIGH PSI
DreEX0024848
(ctnnb1)
Fruitfly
(dm6)
No conservation detected




Primers PCR

	

		

			
Suggestions for RT-PCR validation

			

				
F: 
TCTCCCATTGAAAATATCCAAAGAGT

				
R: 
CATCCTGGCGATATCCAAGGG

				
Band lengths: 
203-325

			

		

	





	
Functional annotations
(Submit an annotation)

	


There are 1 annotated functions for this event 


PMID: 16476742
HsaEX6055279
Encodes an experimentally validated Eukaryotic Linear Motif (ELM). Method: mutation analysis, protein kinase assay, western blot. ELM ID: ELMI001503; ELM sequence: KRLSVEL; Overlap: FULL


		










GENOMIC CONTEXT[edit]












INCLUSION PATTERN[edit]






SPECIAL DATASETS
  • Ribosome-engaged transcriptomes of neuronal types
  • Neural differentiation time course
  • Muscular differentiation time course
  • Spermatogenesis cell types
  • Reprogramming of fibroblasts to iPSCs
  • Hematopoietic precursors and cell types





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