Special

MmuEX6090820 @ mm10

Exon Skipping

Gene
ENSMUSG00000041828 | Abca8a
Description
ATP-binding cassette, sub-family A (ABC1), member 8a [Source:MGI Symbol;Acc:MGI:2386846]
Coordinates
chr11:110057147-110060046:-
Coord C1 exon
chr11:110059880-110060046
Coord A exon
chr11:110058424-110058557
Coord C2 exon
chr11:110057147-110057284
Length
134 bp
Sequences
Splice sites
3' ss Seq
CTTTTACATTTTACTACTAGGAG
3' ss Score
7.15
5' ss Seq
AAGGTACGT
5' ss Score
10.75
Exon sequences
Seq C1 exon
GATTCTGGTTTTGGGGATTGGACTTCTGCATATTTTGTCAGCAAATATTTACAGGATGGTCCGTCAAAGTGACTACTGTTGGGAGCTTGCCCCTCATATGTACTTCCTCACACCAGGCCAGCAACCACAGCCGCCCCTCACGAACTTACTGATCGTCAACAAAACAG
Seq A exon
GAGCAAAAATCGATGACTTTATACATTCACTGGAACAACAGAACATAGCTTTGGAAGTTGATGCCTTTGGGACTAGAAATGGCACCGAGGACAGTCAGTATAATGGAGCTATCATCCTATCAGGTGACGAGAAG
Seq C2 exon
AATTACAACTTTACCCTGGCATGCAACACCAAGAGGCTGAATTGTTTTCCGGTTCTGGTGGATATTGTGAGTAATGGGCTACTTGGACTGTTCGCACCATCAGCACACATTCAAACTGACCGCAGCACATTTCCTGAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000041828-'29-33,'29-32,30-33=AN
Average complexity
A_S
Mappability confidence:
100%=100=100%
Protein Impact





	

	
ORF disruption upon sequence exclusion





No structure available

		

			
Features


			

				
Disorder rate (Iupred):
  C1=0.000 A=0.000 C2=0.022
 
                        

				
Domain overlap (PFAM):

					





						

							
C1:
PF126982=ABC2_membrane_3=FE(15.8=100)

							
A:
PF126982=ABC2_membrane_3=FE(12.4=100)

							
C2:
PF126982=ABC2_membrane_3=FE(12.7=100)

						

					

				








    
Main Inclusion Isoform:
ENSMUSP00000097860





     
                   









    
Main Skipping Isoform:
NA





     
      









    
Other Inclusion Isoforms:
ENSMUSP00000045808, ENSMUSP00000102275
          









    
Other Skipping Isoforms:
NA
  



Associated events






Other assemblies


mm9




Conservation


Human
(hg38)
chr17:69017656-69017789 
HIGH PSI
HsaEX6024427
(ABCA9)
Human
(hg19)
chr17:67178816-67178949 
HIGH PSI
HsaEX6024480
(ABCA10)
Rat
(rn6)
chr10:98352297-98352430 
HIGH PSI
RnoEX0004971
(Abca8a)
Cow
(bosTau6)
chr19:62129984-62130117 
HIGH PSI
BtaEX6091168
(ABCA9)
Chicken
(galGal4)
chr18:8215851-8215978 
HIGH PSI
GgaEX6016342
([1])
Chicken
(galGal3)
chr18:7951342-7951469 
HIGH PSI
GgaEX6016342
([2])
Zebrafish
(danRer10)
No conservation detected
Fruitfly
(dm6)
No conservation detected




Primers PCR

	

		

			
Suggestions for RT-PCR validation

			

				
F: 
ACAGGATGGTCCGTCAAAGTG

				
R: 
TGCTGCGGTCAGTTTGAATGT

				
Band lengths: 
244-378

			

		

	





	
Functional annotations
(Submit an annotation)

	


There are 0 annotated functions for this event 


		










GENOMIC CONTEXT[edit]












INCLUSION PATTERN[edit]






SPECIAL DATASETS
  • Ribosome-engaged transcriptomes of neuronal types
  • Neural differentiation time course
  • Muscular differentiation time course
  • Spermatogenesis cell types
  • Reprogramming of fibroblasts to iPSCs
  • Hematopoietic precursors and cell types





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