Special

MmuEX6102275 @ mm10

Exon Skipping

Gene
ENSMUSG00000042359 | Osbpl6
Description
oxysterol binding protein-like 6 [Source:MGI Symbol;Acc:MGI:2139014]
Coordinates
chr2:76577012-76584548:+
Coord C1 exon
chr2:76577012-76577119
Coord A exon
chr2:76579173-76579310
Coord C2 exon
chr2:76584461-76584548
Length
138 bp
Sequences
Splice sites
3' ss Seq
TCTGCTTCTTTCTCCTGTAGCCT
3' ss Score
10.49
5' ss Seq
GAGGTGGGT
5' ss Score
7.07
Exon sequences
Seq C1 exon
GCACTTAACCAGAACGCTGAGCTCCGGAGTCGGCTGAACAGAATACACTCAGAGTCTACCATTTGTGATCACGTTGTCAGTGTAAATATTATCCCTAGCCCCGATGAG
Seq A exon
CCTGGTGAGCAAATCCATGTCAGCCTCCCTCTGTCACAGCAGGTGGCCAACGAGAGCCGCCTCTCCATGTCAGAATCCGTGTCAGAATTCTTCGATGCCCAAGAGGTGCTCCTGTCTGCAAGCTCATCAGAGAATGAG
Seq C2 exon
GCTTCTGATGATGAGTCCTACATCAGCGACGTGAGTGACAACATATCTGAGGACAACACCAGTGTCGCCGACAACATTTCTCGGCAAA
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000042359-'46-60,'46-54,49-60=AN
Average complexity
A_C1
Mappability confidence:
NA
Protein Impact





	

	
Alternative protein isoforms (Ref)





No structure available

		

			
Features


			

				
Disorder rate (Iupred):
  C1=0.260 A=0.423 C2=0.800
 
                        

				
Domain overlap (PFAM):

					





						

							
C1:
NO

							
A:
NO

							
C2:
NO

						

					

				








    
Main Inclusion Isoform:
ENSMUSP00000077123





     
                   









    
Main Skipping Isoform:
NA





     
      









    
Other Inclusion Isoforms:
ENSMUSP00000107560, ENSMUSP00000107561, ENSMUSP00000139363
          









    
Other Skipping Isoforms:
NA
  



Associated events







Other assemblies


mm9




Conservation


Human
(hg38)
chr2:178373890-178374027 
HIGH PSI
HsaEX6016882
(OSBPL6)
Human
(hg19)
chr2:179238617-179238754 
HIGH PSI
HsaEX6016882
(OSBPL6)
Rat
(rn6)
chr3:63433679-63433816 
HIGH PSI
RnoEX6017496
(Osbpl6)
Cow
(bosTau6)
chr2:18500520-18500657 
HIGH PSI
BtaEX6008883
(OSBPL6)
Chicken
(galGal4)
chr7:14943786-14943923 
HIGH PSI
GgaEX6042217
(OSBPL6)
Chicken
(galGal3)
chr7:16541215-16541352 
HIGH PSI
GgaEX6042217
(E1BQU1_CHICK)
Zebrafish
(danRer10)
chr9:1407424-1407561 
HIGH PSI
DreEX6034687
(osbpl6)
Fruitfly
(dm6)
No conservation detected




Primers PCR

	

		

			
Suggestions for RT-PCR validation

			

				
F: 
CACTTAACCAGAACGCTGAGCT

				
R: 
TTTGCCGAGAAATGTTGTCG

				
Band lengths: 
195-333

			

		

	





	
Functional annotations
(Submit an annotation)

	


There are 2 annotated functions for this event 


PMID: 15212954
HsaEX6016882
Encodes an experimentally validated Eukaryotic Linear Motif (ELM). Method: glutathione s tranferase tag, pull down. ELM ID: ELMI001272; ELM sequence: ESVSEFFDAQE; Overlap: FULL


PMID: 17804640
HsaEX6016882
Encodes an experimentally validated Eukaryotic Linear Motif (ELM). Method: cross linking study, detection by mass spectrometry. ELM ID: ELMI001272; ELM sequence: ESVSEFFDAQE; Overlap: FULL


		










GENOMIC CONTEXT[edit]












INCLUSION PATTERN[edit]






SPECIAL DATASETS
  • Ribosome-engaged transcriptomes of neuronal types
  • Neural differentiation time course
  • Muscular differentiation time course
  • Spermatogenesis cell types
  • Reprogramming of fibroblasts to iPSCs
  • Hematopoietic precursors and cell types





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