DmeEX0008110 @ dm6
Exon Skipping
Gene
FBgn0001147 | gsb-n
Description
The gene gooseberry-neuro is referred to in FlyBase by the symbol Dmelgsb-n (CG2692, FBgn0001147). It is a protein_coding_gene from Dmel. It has 2 annotated transcripts and 2 polypeptides (1 unique). Gene sequence location is 2R:25040383..25052331. Its molecular function is described by: RNA polymerase II regulatory region sequence-specific DNA binding; DNA binding. It is involved in the biological process described with: segment polarity determination; neurogenesis; regulation of transcription, DNA-templated. 27 alleles are reported. The phenotypes of these alleles manifest in: Notch OFF hemilineage primary neuron; Keilin's organ; epidermis; abdominal 6 ventral denticle belt; developing embryonic structure. The phenotypic classes of alleles include: partially lethal; partially lethal - majority live; pair rule phenotype; visible; partially lethal - majority die; wild-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 06-18 hour embryonic stages.
Coordinates
chr2R:25041333-25051623:-
Coord C1 exon
chr2R:25051310-25051623
Coord A exon
chr2R:25048047-25048158
Coord C2 exon
chr2R:25041333-25041926
Length
112 bp
Sequences
Splice sites
3' ss Seq
TTATTTTTTCGATGATGCAGGAG
3' ss Score
6.46
5' ss Seq
GAGGTAAGG
5' ss Score
10.28
Exon sequences
Seq C1 exon
GACAAGGCCGGGTAAATCAGCTTGGGGGCGTCTTTATCAATGGACGTCCGTTGCCCAATCACATTCGACTGAAGATCGTGGAAATGGCGGCCAGTGGAGTGCGGCCTTGTGTAATATCGCGCCAGCTCCGCGTGTCTCACGGCTGCGTATCGAAGATTCTGAACCGATACCAGGAGACGGGTTCTATTAGACCGGGCGTAATAGGTGGATCTAAGCCCAAGGTGACCTCTCCCGAAATTGAAACGCGGATCGATGAGCTGCGAAAGGAAAACCCCAGCATATTCAGCTGGGAAATACGCGAAAAGCTGATAAAG
Seq A exon
GAGGGCTTTGCGGATCCACCATCAACATCGTCGATCAGTCGCTTATTGCGGGGAAGCGATCGCGGCAGCGAAGATGGTCGGAAGGACTATACCATAAATGGAATTCTTGGAG
Seq C2 exon
GGCGAGACTCAGATATAAGTGACACGGAATCGGAGCCTGGGATTCCGCTGAAACGCAAGCAGCGTCGCTCCCGCACCACCTTCACCGCCGAGCAGCTAGAGGCACTCGAGCGAGCCTTTTCCCGCACCCAATACCCGGACGTCTACACCCGGGAAGAGCTGGCTCAGACCACGGCCCTCACCGAAGCCCGTATCCAGGTATGGTTCTCCAACCGCAGGGCACGCCTTCGCAAGCACTCTGGCGGCTCAAACTCCGGGCTTTCGCCCATGAACAGTGGAAGCTCTAATGTGGGCGTGGGTGTTGGGCTCAGTGGGGCGACAGCACCACTTGGCTACGGCCCTTTGGGAGTTGGTTCGATGGCGGGCTACAGTCCTGCGCCGGGAACCACTGCCACTGGAGCTGGGATGAACGACGGAGTTCACCACGCCGCACACGCACCAAGCTCCCACCACAGCGCAGCAACGGCTGCTGCAGCGGCACACCATCACACACAGATGGGT
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0001147_CASSETTE1
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact
ORF disruption upon sequence exclusion
No structure available
Features
Disorder rate (disopred):
C1=0.152 A=0.842 C2=0.749
Domain overlap (PFAM):
C1:
PF0029213=PAX=PU(85.2=99.0)
A:
PF0029213=PAX=PD(13.1=42.1)
C2:
PF0004624=Homeobox=WD(100=28.6)
Main Inclusion Isoform:
FBpp0072363
Main Skipping Isoform:
NA
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
NA
Associated events
Conservation
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
TAAGCCCAAGGTGACCTCTCC
R:
TAGACGTCCGGGTATTGGGTG
Band lengths:
248-360
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)