DmeEX6007367 @ dm6

Exon Skipping

Gene

Description

The gene Myosin heavy chain is referred to in FlyBase by the symbol DmelMhc (CG17927, FBgn0264695). It is a protein_coding_gene from Dmel. It has 22 annotated transcripts and 22 polypeptides (20 unique). Gene sequence location is 2L:16766566..16788766. Its molecular function is described by 6 unique terms, many of which group under: nucleoside-triphosphatase activity; catalytic activity; hydrolase activity, acting on acid anhydrides; drug binding; actin filament binding. It is involved in the biological process described with 15 unique terms, many of which group under: epithelial cell development; adult somatic muscle development; regulation of biological quality; reproductive process; protein stabilization. 161 alleles are reported. The phenotypes of these alleles manifest in: somatic cell of ovariole; muscle attachment site; embryonic/larval heart; adult visceral muscle; germline cell. The phenotypic classes of alleles include: sterile; fertile; phenotype; increased mortality during development.

Coordinates

chr2L:16770457-16771141:+

Coord C1 exon

chr2L:16770457-16770837

Coord A exon

chr2L:16770911-16770974

Coord C2 exon

chr2L:16771043-16771141

Length

64 bp

Sequences

Splice sites

3' ss Seq

CTTATCCCCTTGCAAACCAGGGT

3' ss Score

5.64

5' ss Seq

CCTGTAAGT

5' ss Score

7.52

Exon sequences

Seq C1 exon

ACCTACTCCGGTCTTTTCTGCGTTGCCATCAATCCTTACAAGCGTTACCCCGTGTATACCAACCGTTGCGCTAAGATGTACCGTGGCAAGCGCCGTAATGAGGTGCCACCCCATATTTTCGCCATCTCTGACGGTGCCTACGTCGACATGTTGACCAACCACGTGAATCAATCTATGTTGATCACCGGTGAGTCTGGTGCCGGAAAGACTGAGAACACCAAGAAGGTCATTGCGTACTTCGCCACTGTTGGTGCCTCCAAGAAGACCGATGAGGCCGCCAAGAGCAAGGGCTCCCTGGAAGATCAGGTTGTGCAGACCAACCCTGTGCTTGAGGCCTTCGGTAACGCCAAGACCGTGCGTAACGATAACTCCTCTCGTTTC

Seq A exon

GGTAAATTCATCCGTATCCACTTCGGACCCACTGGTAAACTGGCTGGTGCTGATATTGAGACCT

Seq C2 exon

ATCTGCTGGAGAAGGCTCGTGTCATCTCCCAGCAGTCCCTGGAGCGTTCCTACCACATCTTCTACCAGATCATGTCTGGCTCCGTTCCCGGTGTTAAAG

VastDB Features

Vast-tools module Information

Secondary ID

FBgn0264695-'15-8,'15-7,16-8=AN

Average complexity

A_S

Mappability confidence:

100%=100=100%

Protein Impact

ORF disruption upon sequence exclusion

No structure available

Features

Disorder rate (Iupred):

C1=0.086 A=0.000 C2=0.000

Domain overlap (PFAM):

C1:

PF0006316=Myosin_head=FE(18.6=100)

A:

PF0006316=Myosin_head=FE(3.1=100)

C2:

PF0006316=Myosin_head=FE(4.9=100)

Main Inclusion Isoform:

FBpp0080452

Main Skipping Isoform:

NA

Other Inclusion Isoforms:

FBpp0080453, FBpp0080454, FBpp0080455, FBpp0080456, FBpp0080457, FBpp0080458, FBpp0080459, FBpp0080460, FBpp0080462, FBpp0080463, FBpp0080464, FBpp0291041, FBpp0291042, FBpp0291043, FBpp0298827, FBpp0298828, FBpp0298829, FBpp0298830, FBpp0298831, FBpp0312323

Other Skipping Isoforms:

NA

Associated events

Conservation

Human

(hg38)

chr17:10543098-10543161

HIGH PSI

HsaEX6021060

(MYH2)

Human

(hg19)