DmeEX6008511 @ dm6
Exon Skipping
Gene
FBgn0085421 | Epac
Description
The gene Exchange protein directly activated by cAMP is referred to in FlyBase by the symbol DmelEpac (CG34392, FBgn0085421). It is a protein_coding_gene from Dmel. It has 5 annotated transcripts and 5 polypeptides (4 unique). Gene sequence location is 2R:6759715..6798941. Its molecular function is described by: guanyl-nucleotide exchange factor activity. It is involved in the biological process described with: regulation of Rap protein signal transduction. 20 alleles are reported. No phenotypic data is available. The phenotypic classes of alleles include: fertile; viable. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 12-18 embryonic stages, at stages throughout the pupal period.
Coordinates
chr2R:6773640-6792621:-
Coord C1 exon
chr2R:6792479-6792621
Coord A exon
chr2R:6792316-6792410
Coord C2 exon
chr2R:6773640-6773786
Length
95 bp
Sequences
Splice sites
3' ss Seq
CAAACTTCTCCTCCCCGCAGTTT
3' ss Score
10.2
5' ss Seq
AAGGTAAGT
5' ss Score
11
Exon sequences
Seq C1 exon
TCCTTGCGACCGGAACCTGCGTGATGTGGAGCTAATTTCGTGCCGGTTGCGTCGCGTGGAGCCGCTGTGTCGCCTCCCGGGATCTGCGCTCCAGCAGTTGGCCATGTGCGGATTCTATGAGGACCTGGAGAAGGGGGTGACTC
Seq A exon
TTTTTCGCGCCGGCGAGCAGGGACGCTTCTGGTATGCAGTGCTCGGCGGATCGCTGGAGGTGCGATACCATGCCCACGCCGATGCCGATGGCAAG
Seq C2 exon
AGCGCAGTTACTCTGTGCAACCTGGGCGTGGGTGCCACATTCGGGGAGTCCGTACTGCATGACTTGCCGCGGGACAGCACCGTAGTGACGAAGACCACCTGCGAGCTGCTGCGGGTGGAGCAGCAGGACTTTCGACTCATCTGGGAG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0085421-'6-8,'6-3,7-8=AN
Average complexity
A_S
Mappability confidence:
100%=100=100%
Protein Impact
In the CDS, with uncertain impact
No structure available
Features
Disorder rate (Iupred):
C1=0.000 A=0.000 C2=0.000
Domain overlap (PFAM):
C1:
PF0002724=cNMP_binding=PU(22.0=18.4)
A:
PF0002724=cNMP_binding=FE(33.0=100)
C2:
PF0002724=cNMP_binding=FE(51.1=100)
Main Inclusion Isoform:
FBpp0302889
Main Skipping Isoform:
FBpp0302890
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
NA
Associated events
Conservation
Mouse
(mm9)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
TGGCCATGTGCGGATTCTATG
R:
GAGTCGAAAGTCCTGCTGCTC
Band lengths:
183-278
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)