HsaEX0074408 @ hg19
Exon Skipping
Gene
ENSG00000102984 | ZNF821
Description
zinc finger protein 821 [Source:HGNC Symbol;Acc:28043]
Coordinates
chr16:71898806-71913926:-
Coord C1 exon
chr16:71913810-71913926
Coord A exon
chr16:71901815-71901940
Coord C2 exon
chr16:71898806-71898951
Length
126 bp
Sequences
Splice sites
3' ss Seq
TTTTTCCTTGTGACCACCAGGGG
3' ss Score
7.49
5' ss Seq
GCAGTGAGT
5' ss Score
7.39
Exon sequences
Seq C1 exon
GTTAGCATCTTGCAAGGAGGTAGTAACATATCCAGTCGTGAAACTGGGAAAGACCAGAGCTCTTGCATCAGGGAAACATGTCCCGTCGGAAACAGACAAATCCAAATAAAGTTCACT
Seq A exon
GGGATCAAGTATTTGCTGGGCTAGAAGAGCAAGCCCGCCAGGCGATGATGAAAACTGATTTTCCTGGAGACCTTGGCAGTCAGCGACAAGCTATCCAACAACTAAGAGATCAGGACTCCAGTAGCA
Seq C2 exon
GTGACAGTGAGGGTGATGAAGAGGAGACGACACAAGATGAAGTCTCTTCCCACACATCAGAGGAAGATGGAGGGGTGGTCAAAGTGGAGAAAGAGTTAGAAAATACAGAACAGCCTGTTGGTGGGAACGAAGTGGTAGAGCACGAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSG00000102984_MULTIEX1-1/4=C1-2
Average complexity
C1*
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (No Ref)
No structure available
Features
Disorder rate (Iupred):
C1=1.000 A=0.969 C2=1.000
Domain overlap (PFAM):
C1:
NO
A:
PF0105613=Myc_N=PU(33.0=83.7)
C2:
NO
Other Inclusion Isoforms:
Associated events
Other assemblies
Conservation
Zebrafish
(danRer10)
No conservation detected
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
GCATCTTGCAAGGAGGTAGTAACA
R:
CGTGCTCTACCACTTCGTTCC
Band lengths:
257-383
Functional annotations
There are 1 annotated functions for this event
PMID: 31911676
This event
[CRISPR screen]. Conserved poison exon with pro-oncogenic impact when depleted: HeLa No Change at 14 days (FC=0.846, FDR=0.038), PC9 No Change at 14 days (FC=0.953, FDR=0.584), Late Xenograft Enriched (FC=1.741, FDR=0.002).
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- The Cancer Genome Atlas (TCGA)
- Genotype-Tissue Expression Project (GTEx)
- Autistic and control brains
- Pre-implantation embryo development
Other AS DBs:
FasterDB (Includes CLIP-seq data)
AS-ALPS (AS-induced ALteration of Protein Structure, links to PINs)
APPRIS (Selection of principal isoform)
DEU primates (Only for human)