Special

MmuEX1025330 @ mm10

Exon Skipping

Gene
ENSMUSG00000067629 | Syngap1
Description
synaptic Ras GTPase activating protein 1 homolog (rat) [Source:MGI Symbol;Acc:MGI:3039785]
Coordinates
chr17:26941253-26952653:+
Coord C1 exon
chr17:26941253-26941518
Coord A exon
chr17:26946633-26946738
Coord C2 exon
chr17:26952562-26952653
Length
106 bp
Sequences
Splice sites
3' ss Seq
CACACTCCCCAATCCCCTAGATA
3' ss Score
8.02
5' ss Seq
ATGGTACGG
5' ss Score
8.21
Exon sequences
Seq C1 exon
TCTCTGCTGCCGCTGCTGCCGTTGGCTCTTATTCTCCTCCTCCTCCTCCTCTCTCCTCCTCTCTGCTCCTCTCCGCTCCTCTCTCCTCCTCTCTCCTCCTCCTCCTCCTCCTCCACCTCCTCCTTCTCCCCCTTTCTCTCCCCCTCTTTCTCTCTTCTTTTTCTCCCCCCGTCCCCCCGCCCCCTCCCCCTCAGGCCTGATGAGCAGGTCTCGAGCCTCCATCCATCGGGGGAGCATCCCCGCGATGTCCTATGCCCCCTTCAGAG
Seq A exon
ATACACCCCCTTCTGATCCGCGACCGGAGGAGCGAGTCCAGCCGAAACAAACTGCTGAGACGCACCGTCTCTGTGCCAGTGGAGGGGCGGCCCCACGGCGAGCATG
Seq C2 exon
AATACCACTTGGGTCGCTCGAGGAGGAAGAGTGTCCCAGGGGGGAAACAGTACAGCATGGAGGCCGCCCCCGCTGCGCCCTTCCGGCCCTCG
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000067629_MULTIEX1-4/4=C1-C2
Average complexity
C3
Mappability confidence:
100%=100=100%
Protein Impact





	

	
ORF disruption upon sequence exclusion





No structure available

		

			
Features


			

				
Disorder rate (Iupred):
  C1=0.421 A=0.813 C2=0.779
 
                        

				
Domain overlap (PFAM):

					





						

							
C1:
NO

							
A:
PF0016924=PH=FE(15.8=100)

							
C2:
PF0016924=PH=FE(13.5=100)

						

					

				








    
Main Inclusion Isoform:
ENSMUSP00000141686





     
                   









    
Main Skipping Isoform:
ENSMUST00000194598fB17769





     
      









    
Other Inclusion Isoforms:
ENSMUSP00000137587, ENSMUSP00000141245, ENSMUSP00000144248, ENSMUSP00000144666
          









    
Other Skipping Isoforms:
NA
  



Associated events







Conservation


Human
(hg38)
chr6:33425798-33425903 
HIGH PSI
HsaEX6046665
(SYNGAP1)
Human
(hg19)
chr6:33393575-33393680 
HIGH PSI
HsaEX6046665
(SYNGAP1)
Rat
(rn6)
chr20:5540714-5540819 
ALTERNATIVE
RnoEX0088088
(Syngap1)
Cow
(bosTau6)
chr23:7543388-7543493 
HIGH PSI
BtaEX0035375
(SYNGAP1)
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Fruitfly
(dm6)
No conservation detected




Primers PCR

	

		

			
Suggestions for RT-PCR validation

			

				
F: 
CTCCTCCTCTCTCCTCCTCCT

				
R: 
CCATGCTGTACTGTTTCCCCC

				
Band lengths: 
244-350

			

		

	





	
Functional annotations
(Submit an annotation)

	


There are 0 annotated functions for this event 


		










GENOMIC CONTEXT[edit]












INCLUSION PATTERN[edit]






SPECIAL DATASETS
  • Ribosome-engaged transcriptomes of neuronal types
  • Neural differentiation time course
  • Muscular differentiation time course
  • Spermatogenesis cell types
  • Reprogramming of fibroblasts to iPSCs
  • Hematopoietic precursors and cell types





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