Special

MmuEX6101027 @ mm10

Exon Skipping

Gene
ENSMUSG00000049252 | Lrp1b
Description
low density lipoprotein-related protein 1B (deleted in tumors) [Source:MGI Symbol;Acc:MGI:2151136]
Coordinates
chr2:41375834-41408982:-
Coord C1 exon
chr2:41408902-41408982
Coord A exon
chr2:41408235-41408402
Coord C2 exon
chr2:41375834-41376016
Length
168 bp
Sequences
Splice sites
3' ss Seq
CTTTCAGTATTTCTTTCCAGATG
3' ss Score
8.62
5' ss Seq
AGGGTGAGT
5' ss Score
9.25
Exon sequences
Seq C1 exon
AATTTCCAACCTGTGAGCCTCTGACTCAGTTCATATGCAAGAGTGGGAGATGCATCAGCAACAAATGGCACTGCGACACTG
Seq A exon
ATGATGACTGTGGAGACAGGAGTGATGAGGTGGGCTGTGTTCACTCCTGCCTTGATGACCAGTTCAGATGTTCAAGTGGCCGGTGTATCCCAGGGCACTGGGCCTGTGATGGTGACAATGACTGCGGAGACTTCAGTGATGAAACACATATCAATTGTACAAAAGAGG
Seq C2 exon
AAGCTCGTTCTCCTGCTGGTTGCATCGGGAATGAATTTCAGTGCCGTCCTGATGGAAACTGCATCCCTGATCTGTGGCGCTGTGATGGAGAGAAAGACTGTGAGGATGGCAGTGATGAGAAGGGCTGCAATGGTACCATTCGACTGTGTGACCACAAAACCAAGTTTTCCTGCAGGAGTACAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000049252-'38-33,'38-32,39-33=AN
Average complexity
A_C3
Mappability confidence:
NA
Protein Impact





	

	
Alternative protein isoforms (Ref)





No structure available

		

			
Features


			

				
Disorder rate (Iupred):
  C1=0.000 A=0.000 C2=0.000
 
                        

				
Domain overlap (PFAM):

					





						

							
C1:
PF0005713=Ldl_recept_a=PU(65.8=89.3)

							
A:
PF0005713=Ldl_recept_a=PD(31.6=21.1),PF0005713=Ldl_recept_a=WD(100=68.4)

							
C2:
PF0005713=Ldl_recept_a=WD(100=61.3),PF0005713=Ldl_recept_a=PU(35.9=22.6)

						

					

				








    
Main Inclusion Isoform:
ENSMUSP00000054275





     
                   









    
Main Skipping Isoform:
NA





     
      









    
Other Inclusion Isoforms:
ENSMUSP00000129192, ENSMUSP00000145278
          









    
Other Skipping Isoforms:
NA
  



Associated events







Other assemblies


mm9




Conservation


Human
(hg38)
chr2:140950235-140950402 
HIGH PSI
HsaEX0036409
(LRP1B)
Human
(hg19)
chr2:141707804-141707971 
HIGH PSI
HsaEX0036409
(LRP1B)
Rat
(rn6)
chr3:26024509-26024676 
HIGH PSI
RnoEX6016696
(AABR07051892.1)
Cow
(bosTau6)
chr2:56171131-56171292 
Chicken
(galGal4)
chr7:31527791-31527958 
ALTERNATIVE
GgaEX1033880
(LRP1B)
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
chr22:14603657-14603821 
HIGH PSI
DreEX6098162
(lrp1ba)
Fruitfly
(dm6)
No conservation detected




Primers PCR

	

		

			
Suggestions for RT-PCR validation

			

				
F: 
TTCTTTCTTTCCTTCTTTCTTCCTTC

				
R: 
CATAGCAGGTTTTCTTGTCAGAGGA

				
Band lengths: 
210-378

			

		

	





	
Functional annotations
(Submit an annotation)

	


There are 0 annotated functions for this event 


		










GENOMIC CONTEXT[edit]












INCLUSION PATTERN[edit]






SPECIAL DATASETS
  • Ribosome-engaged transcriptomes of neuronal types
  • Neural differentiation time course
  • Muscular differentiation time course
  • Spermatogenesis cell types
  • Reprogramming of fibroblasts to iPSCs
  • Hematopoietic precursors and cell types





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