DmeEX0008108 @ dm6
Exon Skipping
Gene
FBgn0001147 | gsb-n
Description
The gene gooseberry-neuro is referred to in FlyBase by the symbol Dmelgsb-n (CG2692, FBgn0001147). It is a protein_coding_gene from Dmel. It has 2 annotated transcripts and 2 polypeptides (1 unique). Gene sequence location is 2R:25040383..25052331. Its molecular function is described by: RNA polymerase II regulatory region sequence-specific DNA binding; DNA binding. It is involved in the biological process described with: segment polarity determination; neurogenesis; regulation of transcription, DNA-templated. 27 alleles are reported. The phenotypes of these alleles manifest in: Notch OFF hemilineage primary neuron; Keilin's organ; epidermis; abdominal 6 ventral denticle belt; developing embryonic structure. The phenotypic classes of alleles include: partially lethal; partially lethal - majority live; pair rule phenotype; visible; partially lethal - majority die; wild-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 06-18 hour embryonic stages.
Coordinates
chr2R:25048047-25052331:-
Coord C1 exon
chr2R:25051951-25052331
Coord A exon
chr2R:25051310-25051623
Coord C2 exon
chr2R:25048047-25048158
Length
314 bp
Sequences
Splice sites
3' ss Seq
TTGATCTAACTTGCCCACAGGAC
3' ss Score
9.64
5' ss Seq
AAGGTGAGT
5' ss Score
10.47
Exon sequences
Seq C1 exon
TTTAGTTGCTTTGCACGTCTCGTGCAGTTTGATCGCTGAAGCGCGCGTGATTCCAAGAAAAATCCCGCTTCTCACCACCGGACTGAGAGTTGCAAAGTACCGTCGGAATCGGGAGCCGCCCGTCGTAGTGATGAAGTGGGTCCTTTGGGCCAGCTTTAAGTGATTTCCCACAAGGAACGACAGCCTACTGATCATAGCTCATTTCAAATATAATTGTGCAATGGTATCGACTCGGATGCACTAACCTACCGAAAATAAAGAAAGTTTTTTGAGTGCAGCGTCGCTTAGATTCTCGATTGCTATAAGCTCTTTGCATTCGGACCATGGATATGTCCAGCGCGAACTCGTTGCGGCCCCTTTTCGCAGGGTATCCCTTTCAAG
Seq A exon
GACAAGGCCGGGTAAATCAGCTTGGGGGCGTCTTTATCAATGGACGTCCGTTGCCCAATCACATTCGACTGAAGATCGTGGAAATGGCGGCCAGTGGAGTGCGGCCTTGTGTAATATCGCGCCAGCTCCGCGTGTCTCACGGCTGCGTATCGAAGATTCTGAACCGATACCAGGAGACGGGTTCTATTAGACCGGGCGTAATAGGTGGATCTAAGCCCAAGGTGACCTCTCCCGAAATTGAAACGCGGATCGATGAGCTGCGAAAGGAAAACCCCAGCATATTCAGCTGGGAAATACGCGAAAAGCTGATAAAG
Seq C2 exon
GAGGGCTTTGCGGATCCACCATCAACATCGTCGATCAGTCGCTTATTGCGGGGAAGCGATCGCGGCAGCGAAGATGGTCGGAAGGACTATACCATAAATGGAATTCTTGGAG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0001147-'0-1,'0-0,1-1
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact
ORF disruption upon sequence exclusion
No structure available
Features
Disorder rate (disopred):
C1=1.000 A=0.152 C2=0.842
Domain overlap (PFAM):
C1:
PF0029213=PAX=PU(0.1=0.0)
A:
PF0029213=PAX=PU(85.2=99.0)
C2:
PF0029213=PAX=PD(13.1=42.1)
Main Inclusion Isoform:
FBpp0072363
Main Skipping Isoform:
NA
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
NA
Associated events
Conservation
Primers PCR
Suggestions for RT-PCR validation
F:
AAAATCCCGCTTCTCACCACC
R:
GATGTTGATGGTGGATCCGCA
Band lengths:
352-666
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)