Special

DmeEX6015350 @ dm6

Exon Skipping

Gene
FBgn0053276 | CG33276
Description
The gene Ubiquitin-related modifier 1 is referred to in FlyBase by the symbol DmelUrm1 (CG33276, FBgn0053276). It is a protein_coding_gene from Dmel. It has 2 annotated transcripts and 2 polypeptides (1 unique). Gene sequence location is 3L:7639811..7640446. Its molecular function is described by: protein tag; sulfur carrier activity. It is involved in the biological process described with: negative regulation of JNK cascade; tRNA wobble position uridine thiolation; protein urmylation. 14 alleles are reported. The phenotype of these alleles manifest in: anterior crossvein. The phenotypic classes of alleles include: increased mortality during development; phenotype; increased mortality; visible. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed within 00-18 hour embryonic stages, at stages throughout the larval period, during early pupal stages, in adult female stages.
Coordinates
chr3L:7639811-7640206:-
Coord C1 exon
chr3L:7640125-7640206
Coord A exon
chr3L:7640016-7640064
Coord C2 exon
chr3L:7639811-7639959
Length
49 bp
Sequences
Splice sites
3' ss Seq
TTTCTATTGTATGTTTTCAGGCG
3' ss Score
9.32
5' ss Seq
CTGGTAAGT
5' ss Score
10.65
Exon sequences
Seq C1 exon
GGACTATTGCTAATCTGCTTAAGTGGATGCATGCGAATATTTTAACGGAGCGTCCGGAACTTTTTCTTCAAGGAGATACTGT
Seq A exon
GCGACCTGGAATTTTAGTACTCATAAATGATACAGACTGGGAATTGCTG
Seq C2 exon
GGTGAACTGGACTACGAGCTGCAGCCCAACGACAATGTGTTGTTTATATCAACTTTACACGGTGGTTAAAAAACGTTCTGGAATCTAAATTATAGGAGAAAAGTTTATTTTTATACTACAACCCATTAAATTGTATTCAAAAAACAAAC
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0053276-'3-4,'3-3,4-4=AN
Average complexity
A_S
Mappability confidence:
100%=100=100%
Protein Impact

ORF disruption upon sequence exclusion

No structure available
Features
Disorder rate (Iupred):
  C1=0.000 A=0.000 C2=0.000
Domain overlap (PFAM):

C1:
PF091386=Urm1=FE(28.4=100)
A:
PF091386=Urm1=FE(16.8=100)
C2:
PF091386=Urm1=PD(22.1=91.3)


Main Inclusion Isoform:
FBpp0113022


Main Skipping Isoform:
NA


Other Inclusion Isoforms:
NA


Other Skipping Isoforms:
NA
Associated events
Primers PCR
Suggestions for RT-PCR validation
F:
TGCTTAAGTGGATGCATGCGA
R:
TTTTTAACCACCGTGTAAAGTTGA
Band lengths:
139-188
Functional annotations
There are 0 annotated functions for this event


GENOMIC CONTEXT[edit]

INCLUSION PATTERN[edit]


SPECIAL DATASETS

  • Neural diversity
  • Neurogenesis
  • Neuronal activity
  • Splicing factor regulation (brain)
  • Splicing factor regulation (SL2)