GgaEX1015763 @ galGal4
Exon Skipping
Gene
ENSGALG00000014632 | CLK2
Description
dual specificity protein kinase CLK2 [Source:RefSeq peptide;Acc:NP_001026497]
Coordinates
JH375217.1:7449-9894:-
Coord C1 exon
JH375217.1:9660-9894
Coord A exon
JH375217.1:7877-7970
Coord C2 exon
JH375217.1:7449-7515
Length
94 bp
Sequences
Splice sites
3' ss Seq
CTGTCTGCCTGGGCCAGCAGCGG
3' ss Score
2.96
5' ss Seq
GATGTACAG
5' ss Score
-3.25
Exon sequences
Seq C1 exon
CTACGACGACCACTCAGCAGACAGGAGGGCCTACGACCGCCGTTACTGTGACAGCTACCGGCGCAACGATTACAGCCGTGAGCGAGGAGAGCCCTACTACGACCCCGAGTACCGGCATTCCTACGAGTACCGGCGCTCCCGGGACCGCGACGGCAGCTACCGGAGCTGCAAAAGCAGCCGGCGTAAGCACAGGCGGAGGCGGCGGCGCAGCCGGTCCTTTAGTCGCTCCTCATCG
Seq A exon
CGGAGTCGACAGAGCAGCAGAAGGGCCAAGAGTGTGGAGGACGACGACGAGGGGCATCTGATCTATCGCGTCGGCGACTGGCTACAAGAAAGAT
Seq C2 exon
ATGAGATTCTCAGCACTTTAGGGGAAGGCACGTTCGGCAGAGTGGTGCAGTGCATGGATCACCGGAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSGALG00000014632_CASSETTE4
Average complexity
S*
Mappability confidence:
100%=100=100%
Protein Impact
ORF disruption upon sequence exclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.835 A=0.406 C2=0.000
Domain overlap (PFAM):
C1:
NO
A:
PF0006920=Pkinase=PU(0.1=0.0)
C2:
PF0006920=Pkinase=PU(6.9=95.7)
Main Skipping Isoform:
NA
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
NA
Associated events
Conservation
Primers PCR
Suggestions for RT-PCR validation
F:
CTACTACGACCCCGAGTACCG
R:
GTGCCTTCCCCTAAAGTGCTG
Band lengths:
173-267
Functional annotations
There are 1 annotated functions for this event
PMID: 16371011
Skipping of exon 4 (HsaEX0015698) increases in brain areas affected by Alzheimer's Disease resulting in increased expression levels of clk2tr. Increased expression of clk2 full-length induces skipping of clk2 exon 4. Increased expression of clk2tr does not promote skipping of clk2 exon 4.
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]