Special

MmuEX0014206 @ mm9

Exon Skipping

Gene
ENSMUSG00000035392 | Dennd1a
Description
DENN/MADD domain containing 1A [Source:MGI Symbol;Acc:MGI:2442794]
Coordinates
chr2:37992446-38098992:-
Coord C1 exon
chr2:38098922-38098992
Coord A exon
chr2:38015327-38015370
Coord C2 exon
chr2:37992446-37992495
Length
44 bp
Sequences
Splice sites
3' ss Seq
TATCTGTCAATTATTTACAGATC
3' ss Score
7.84
5' ss Seq
CAGGTTTGG
5' ss Score
5.63
Exon sequences
Seq C1 exon
GCAAAACCCAGAGACTACATTTGAAGTGTATGTGGAAGTGGCTTATCCTAGGACAGGTGGCACTCTTTCAG
Seq A exon
ATCCTGAGGTGCAGAGGCAATTCCCAGAGGACTACAGTGACCAG
Seq C2 exon
GAAGTTCTACAGACTTTGACCAAGTTTTGTTTTCCCTTCTATGTGGACAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000035392-'3-8,'3-6,8-8
Average complexity
C1
Mappability confidence:
100%=100=100%
Protein Impact





	

	
ORF disruption upon sequence exclusion





No structure available

		

			
Features


			

				
Disorder rate (Iupred):
  C1=0.139 A=0.318 C2=0.000
 
                        

				
Domain overlap (PFAM):

					





						

							
C1:
PF0345613=uDENN=PU(0.1=0.0)

							
A:
PF0345613=uDENN=PU(23.0=93.3)

							
C2:
PF0345613=uDENN=FE(26.2=100)

						

					

				








    
Main Inclusion Isoform:
ENSMUSP00000099848f6225A





     
                   









    
Main Skipping Isoform:
ENSMUSP00000120998





     
      









    
Other Inclusion Isoforms:
ENSMUSP00000047498, ENSMUSP00000088520, ENSMUSP00000088520f3401A, ENSMUSP00000099848, ENSMUSP00000099848f3398A, ENSMUSP00000099848f3399A, ENSMUSP00000099848f3400A, ENSMUSP00000099848f3402A, ENSMUSP00000099848f6224A, ENSMUSP00000116018, ENSMUSP00000116396, ENSMUSP00000116723, ENSMUSP00000119892
          









    
Other Skipping Isoforms:
NA
  



Associated events







Other assemblies


mm10




Conservation


Human
(hg38)
chr9:123792587-123792630 
HIGH PSI
HsaEX0019091
(DENND1A)
Human
(hg19)
chr9:126554866-126554909 
HIGH PSI
HsaEX0019091
(DENND1A)
Rat
(rn6)
chr3:22413245-22413288 
HIGH PSI
RnoEX0027095
(Dennd1a)
Cow
(bosTau6)
chr11:94911066-94911109 
HIGH PSI
BtaEX0011023
(DENND1A)
Chicken
(galGal4)
chr17:9169571-9169614 
HIGH PSI
GgaEX0001242
(DENND1A)
Chicken
(galGal3)
chr17:9883148-9883191 
HIGH PSI
GgaEX0001242
(DENND1A)
Zebrafish
(danRer10)
No conservation detected
Fruitfly
(dm6)
chr2R:9126181-9126213 
ALTERNATIVE
DmeEX0001313
(CG18659)




Primers PCR

	

		

			
Suggestions for RT-PCR validation

			

				
F: 
ACCCAGAGACTACATTTGAAGTGT

				
R: 
CTGTCCACATAGAAGGGAAAACA

				
Band lengths: 
116-160

			

		

	





	
Functional annotations
(Submit an annotation)

	


There are 0 annotated functions for this event 


		










GENOMIC CONTEXT[edit]












INCLUSION PATTERN[edit]






SPECIAL DATASETS
  • Pre-implantation embryo development
  • Neural differentiation time course
  • Muscular differentiation time course
  • Spermatogenesis cell types
  • Reprogramming of fibroblasts to iPSCs
  • Hematopoietic precursors and cell types






Retrieved from "https://vastdb.crg.eu/wiki/Special:VastDB"