Special

MmuEX0024723 @ mm10

Exon Skipping

Gene
ENSMUSG00000030102 | Itpr1
Description
inositol 1,4,5-trisphosphate receptor 1 [Source:MGI Symbol;Acc:MGI:96623]
Coordinates
chr6:108395976-108406218:+
Coord C1 exon
chr6:108395976-108396113
Coord A exon
chr6:108399250-108399375
Coord C2 exon
chr6:108406090-108406218
Length
126 bp
Sequences
Splice sites
3' ss Seq
CTGTTTCTCCTCTCACACAGGCC
3' ss Score
10.43
5' ss Seq
GGGGTGAGA
5' ss Score
4.74
Exon sequences
Seq C1 exon
ATTTTGATTCGACTTAGCAAGCTCTGCGTGCAGGAGAGCGCGTCGGTGAGGAAGAGCCGGAAGCAGCAGCAACGACTGCTGAGGAACATGGGCGCACACGCTGTGGTGCTGGAGCTGCTGCAGATCCCCTACGAGAAG
Seq A exon
GCCGAAGACACAAAGATGCAAGAGATCATGCGGCTGGCTCATGAATTTTTGCAGAATTTCTGTGCAGGCAACCAGCAGAATCAAGCTTTGCTGCATAAACACATAAACCTGTTTCTCAACCCAGGG
Seq C2 exon
GCCTGTAACAACACAAGCGACAGGAAGCACGCAGACTCCATTCTGGAGAAGTACGTCACTGAAATCGTGATGAGCATCGTCACCACCTTCTTCAGCTCTCCCTTCTCAGACCAGAGCACCACTCTGCAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000030102_MULTIEX1-29/59=28-33
Average complexity
C2
Mappability confidence:
96%=97=100%
Protein Impact





	

	
Alternative protein isoforms (Ref)





No structure available

		

			
Features


			

				
Disorder rate (Iupred):
  C1=0.065 A=0.000 C2=0.000
 
                        

				
Domain overlap (PFAM):

					





						

							
C1:
PF0136516=RYDR_ITPR=FE(25.0=100)

							
A:
PF0136516=RYDR_ITPR=FE(22.8=100)

							
C2:
NO

						

					

				








    
Main Inclusion Isoform:
ENSMUSP00000032192





     
                   









    
Main Skipping Isoform:
NA





     
      









    
Other Inclusion Isoforms:
ENSMUSP00000144880
          









    
Other Skipping Isoforms:
NA
  



Associated events







Other assemblies


mm9




Conservation


Human
(hg38)
chr3:4688495-4688620 
ALTERNATIVE
HsaEX0032550
(ITPR1)
Human
(hg19)
chr3:4730179-4730304 
HIGH PSI
HsaEX0032550
(ITPR1)
Rat
(rn6)
chr4:140432297-140432422 
HIGH PSI
RnoEX6014531
(Itpr1)
Cow
(bosTau6)
chr22:21772643-21772768 
HIGH PSI
BtaEX6093953
(ITPR1)
Chicken
(galGal4)
chr12:18452788-18452913 
HIGH PSI
GgaEX1030870
(ITPR1)
Chicken
(galGal3)
chr12:19096424-19096549 
HIGH PSI
GgaEX1030870
(Q9DEX2_CHICK)
Zebrafish
(danRer10)
chr11:35663384-35663509 
HIGH PSI
DreEX6092755
(itpr1b)
Fruitfly
(dm6)
No conservation detected




Primers PCR

	

		

			
Suggestions for RT-PCR validation

			

				
F: 
CAAGCTCTGCGTGCAGGAG

				
R: 
GAGTGGTGCTCTGGTCTGAGA

				
Band lengths: 
245-371

			

		

	





	
Functional annotations
(Submit an annotation)

	


There are 0 annotated functions for this event 


		










GENOMIC CONTEXT[edit]












INCLUSION PATTERN[edit]






SPECIAL DATASETS
  • Pre-implantation embryo development
  • Ribosome-engaged transcriptomes of neuronal types
  • Neural differentiation time course
  • Muscular differentiation time course
  • Spermatogenesis cell types
  • Reprogramming of fibroblasts to iPSCs
  • Hematopoietic precursors and cell types





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