Special

MmuEX6066641 @ mm10

Exon Skipping

Gene
ENSMUSG00000036466 | Megf11
Description
multiple EGF-like-domains 11 [Source:MGI Symbol;Acc:MGI:1920951]
Coordinates
chr9:64653070-64679299:+
Coord C1 exon
chr9:64653070-64653282
Coord A exon
chr9:64660340-64660514
Coord C2 exon
chr9:64679179-64679299
Length
175 bp
Sequences
Splice sites
3' ss Seq
TCCTTCTGTCCTCTATTCAGCTG
3' ss Score
9.59
5' ss Seq
ATGGTAAGT
5' ss Score
11.01
Exon sequences
Seq C1 exon
GTGTCAAGAAGAATGTCCCTTTGGAACGTTCGGTTTCCTGTGCTCTCAACGCTGTGACTGCCACAATGGAGGTCAATGTTCACCAGCCACAGGGGCCTGTGAGTGTGAGCCTGGCTACAAGGGCCCTAGCTGCCAGGAGCGGCTATGCCCTGAGGGCCTGCATGGCCCAGGCTGCACCTTGCCCTGCCCCTGTGACACCGAGAACACTATCAG
Seq A exon
CTGCCATCCAGTTACTGGAGCTTGTACCTGCCAACCAGGCTGGTCTGGCCACTACTGCAATGAGTCCTGCCCCGCCGGCTACTATGGCAACGGTTGCCAGCTACCCTGCACCTGCCAGAACGGTGCTGACTGCCACAGTATCACCGGGAGCTGCACTTGTGCTCCAGGCTTCATG
Seq C2 exon
GGAGAGGTGTGTGCCGTCCCCTGTGCTGCAGGGACCTATGGTCCCAACTGTTCATCTGTATGTAGCTGTAGCAACGGCGGCACCTGTTCCCCAGTGGATGGCTCCTGCACCTGCCGAGAGG
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000036466-'21-22,'21-19,22-22
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact





	

	
ORF disruption upon sequence exclusion





No structure available

		

			
Features


			

				
Disorder rate (Iupred):
  C1=0.000 A=0.000 C2=0.000
 
                        

				
Domain overlap (PFAM):

					





						

							
C1:
PF0005319=Laminin_EGF=PD(39.5=23.6),PF0005319=Laminin_EGF=PU(18.8=12.5)

							
A:
PF0005319=Laminin_EGF=PD(79.2=64.4)

							
C2:
PF079748=EGF_2=PU(77.4=58.5)

						

					

				








    
Main Inclusion Isoform:
ENSMUSP00000128672





     
                   









    
Main Skipping Isoform:
NA





     
      









    
Other Inclusion Isoforms:
ENSMUSP00000065353, ENSMUSP00000091349, ENSMUSP00000114035, ENSMUSP00000120514
          









    
Other Skipping Isoforms:
NA
  



Associated events






Other assemblies


mm9




Conservation


Human
(hg38)
chr15:65957547-65957721 
ALTERNATIVE
HsaEX0038727
(MEGF11)
Human
(hg19)
chr15:66249885-66250059 
HIGH PSI
HsaEX0038727
(MEGF11)
Rat
(rn6)
chr8:70136462-70136636 
HIGH PSI
RnoEX6036180
(Megf11)
Cow
(bosTau6)
chr10:12787416-12787590 
HIGH PSI
BtaEX6051102
(MEGF11)
Chicken
(galGal4)
chr10:17735115-17735289 
HIGH PSI
GgaEX6008286
(MEGF11)
Chicken
(galGal3)
chr10:20396369-20396543 
HIGH PSI
GgaEX6008286
([1])
Zebrafish
(danRer10)
chr18:19239651-19239825 
HIGH PSI
DreEX6065227
(megf11)
Fruitfly
(dm6)
No conservation detected




Primers PCR

	

		

			
Suggestions for RT-PCR validation

			

				
F: 
GTGCTCTCAACGCTGTGACTG

				
R: 
CGCCGTTGCTACAGCTACATA

				
Band lengths: 
253-428

			

		

	





	
Functional annotations
(Submit an annotation)

	


There are 0 annotated functions for this event 


		










GENOMIC CONTEXT[edit]












INCLUSION PATTERN[edit]






SPECIAL DATASETS
  • Ribosome-engaged transcriptomes of neuronal types
  • Neural differentiation time course
  • Muscular differentiation time course
  • Spermatogenesis cell types
  • Reprogramming of fibroblasts to iPSCs
  • Hematopoietic precursors and cell types





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