BtaEX0028973 @ bosTau6
Exon Skipping
Gene
ENSBTAG00000014947 | PTPN13
Description
Bos taurus protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) (PTPN13), mRNA. [Source:RefSeq mRNA;Acc:NM_174590]
Coordinates
chr6:103415717-103442338:+
Coord C1 exon
chr6:103415717-103415804
Coord A exon
chr6:103426599-103427165
Coord C2 exon
chr6:103442243-103442338
Length
567 bp
Sequences
Splice sites
3' ss Seq
ATAGATTCTTATCATTCCAGGAA
3' ss Score
5.73
5' ss Seq
AAGGTTAGT
5' ss Score
8.54
Exon sequences
Seq C1 exon
ACGGATCAGCTTTCCCGTAGCAGCGAGCAAAAGCCTGATCGAAGCCAGGCTATCCGAGACCGATTGAGAGGAAAAGGATTACCAACAG
Seq A exon
GAAGAAGCTCTACTTCTGATGTTCTAGACACATACAAGTCTCCATTCTGTCATCAGGCCTTTCTTAACAAAGGGCTTAGTAAATCCATGGGATTTCTATCTATCAAAGATACACGAGATGAGGAAGATTATTTCAAGGACCTTTCATCAGATAATAACTCTGGACAAGAAGATTCGGAAAATTCCTGCTCCCCTTACCCGTTCAAATCTAGTGGCCCAGAAAAAAAAGCTGTCCCTGGCCTCGACGTGCTTCCCAAGAAGAAGATCTGGGCTTCGTCCATGGACTTGCTTTGTACAGGTGACAGAGACTTCTCTTCTGGGGAGACTGACAGATACCAACGCCGTCTCCCTGAGGCGGTTACCGTGCGGACTTCAACCACTCCTAGAAAAAAGGAGGCAAGATACTCAGATGGAAGCCTAGCCTTGGATATCTTCGGGCCTCAGAAAATGGATCCAGCATTTCACACACGAGACTTGCCCACCTCCTCGGCAATATCAAGTGCTTTGGACCGAATCCGAGAAAGACAAAAGAAACTTCAGGTTCTGAGAGAAGCCATGAATGTAGAAG
Seq C2 exon
AACCAGTTCAAAGATACAAAACTTACCACAGTGATCTCTTTAGTACATCCAGTGAAAGTCCATCTATTATTTCCTCTGAATCAGATTTCAGGCAAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSBTAG00000014947_CASSETTE1
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (Ref)
No structure available
Features
Disorder rate (Iupred):
C1=0.867 A=0.537 C2=0.697
Domain overlap (PFAM):
C1:
NO
A:
NO
C2:
NO
Main Skipping Isoform:
NA
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
NA
Associated events
Conservation
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
No suggested primer sequences
R:
No suggested primer sequences
Band lengths:
Functional annotations
There are 1 annotated functions for this event
PMID: 12529439
Here the authors show that PTP-BL is involved in the regulation of cytokinesis. The authors demonstrate localization of endogenous PTP-BL at the centrosomes during inter- and metaphase and at the spindle midzone during anaphase. Finally PTP-BL is concentrated at the midbody in cytokinesis. The authors show that PTP-BL is targeted to the midbody and centrosome by a specific splicing variant of the N-terminus characterized by an insertion of 182 amino acids (HsaEX0050973). Additionally, the splice variant with the insert leads to multinucleated cells when overexpressed in HeLas.
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Pre-implantation embryo development