Special

GgaEX1046983 @ galGal4

Exon Skipping

Gene
Description
protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) [Source:HGNC Symbol;Acc:HGNC:9646]
Coordinates
chr4:45272118-45292380:-
Coord C1 exon
chr4:45292287-45292380
Coord A exon
chr4:45280183-45280746
Coord C2 exon
chr4:45272118-45272213
Length
564 bp
Sequences
Splice sites
3' ss Seq
GAAATGTCTCCTTGTTCCAGGAA
3' ss Score
9.01
5' ss Seq
AAGGTTAGT
5' ss Score
8.54
Exon sequences
Seq C1 exon
ATGGATCAGCTTTCTTGCAATGGAGATAAAAAATTGCAGCCAGACAGGAGCCAGGCAATTCGGGAGAGGCTGAGGGGAAAAGGACTGCCCACAG
Seq A exon
GAAAAGCCTCAGTGGTTGATGCACGTGACGAACACAAGACTAATTTCTCTCAACAGACAATGCTTAACAAAGGGCTTAGCAAGTCGATGGGATTTCTGGCCATGAGAGGAACACAAGGCGAAGAGGAATTTTTCCAGGGCATTTCTTCAGATTACAACTCAGGACAGGAAGATTCTTTCTATCCTTACAGATGTAAAACCAATGAGTTTGAAAACAAAGGTCACCTCCATACAGATGCAGCTCCCAAGCGGAAGGTATGGGCTTCCTCCACAGACTTGCTTTGCACGACCAACAGAGCAACTGAAAGGGACCATGCTTCAGACTCTCACAGGCACAGTCATCAATGTGAGACCTTCGCGGTACGGACTTCTACTATGACCAGAAACAAAGAGGCTAGATACTCCGATGGGAGCATAGCACTGGATATCTTTGGACCTCAGAAAGTGGACCAAACGTGCCACGTGCCTGAGACATCAACTTCTGCAGCAATATCGAGTGCCTTTGACAGGATAAGGGAGAGACAGAAGAAGTTGCAGCTCCTGAGGGAAGCCATGAGTGTAGAAG
Seq C2 exon
AGCCTCTGAGAAGGTACAAATCATACCACAGCGATGTTTACAGTACTTCGAGTGAAAGTCCATCCATTATTTCTTCAGAAGCAGATTTCAGGCAAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSGALG00000011078-'13-13,'13-9,14-13
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact

Alternative protein isoforms (Ref)

No structure available
Features
Disorder rate (Iupred):
  C1=0.562 A=0.455 C2=0.479
Domain overlap (PFAM):

C1:
NO
A:
NO
C2:
NO


Main Inclusion Isoform:


Main Skipping Isoform:
NA


Other Inclusion Isoforms:
NA


Other Skipping Isoforms:
NA
Associated events
Other assemblies
Conservation
Zebrafish
(danRer10)
HIGH PSI
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
ATGGATCAGCTTTCTTGCAATGGA
R:
CTTGCCTGAAATCTGCTTCTGA
Band lengths:
190-754
Functional annotations
There are 1 annotated functions for this event
PMID: 12529439
Here the authors show that PTP-BL is involved in the regulation of cytokinesis. The authors demonstrate localization of endogenous PTP-BL at the centrosomes during inter- and metaphase and at the spindle midzone during anaphase. Finally PTP-BL is concentrated at the midbody in cytokinesis. The authors show that PTP-BL is targeted to the midbody and centrosome by a specific splicing variant of the N-terminus characterized by an insertion of 182 amino acids (HsaEX0050973). Additionally, the splice variant with the insert leads to multinucleated cells when overexpressed in HeLas.


GENOMIC CONTEXT[edit]

INCLUSION PATTERN[edit]