DmeEX0008170 @ dm6
Exon Skipping
Gene
FBgn0010114 | hig
Description
The gene hikaru genki is referred to in FlyBase by the symbol Dmelhig (CG2040, FBgn0010114). It is a protein_coding_gene from Dmel. It has 5 annotated transcripts and 5 polypeptides (4 unique). Gene sequence location is 2R:9227785..9247249. Its molecular function is unknown. It is involved in the biological process described with: synaptic target recognition. 20 alleles are reported. The phenotype of these alleles manifest in: central nervous system. The phenotypic classes of alleles include: behavior defective; phenotype; locomotor behavior defective; increased mortality during development. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed within 12-24 hour embryonic stages, during early larval stages, during late pupal stages, in adult male stages.
Coordinates
chr2R:9227785-9230086:-
Coord C1 exon
chr2R:9229598-9230086
Coord A exon
chr2R:9229094-9229276
Coord C2 exon
chr2R:9227785-9228787
Length
183 bp
Sequences
Splice sites
3' ss Seq
CCGCTGCCCCCCCCCCGCAGTCA
3' ss Score
10.36
5' ss Seq
TTTGTAAGT
5' ss Score
7.4
Exon sequences
Seq C1 exon
GATGGTCTCCAGCCCAGGAGGAGAAAGCGGTGCGCTACCGGCTGAGCATCAAGAATATCGAGAACAACGACTCCGGCACCTTCACCTGCACCTCGCCGCGCGGACTGACCAACAGCATTGCCGTCGTGGTGGCCACTTCGACGTGTCCGCAGCTAACAGAGCCGCTGGCGCCGCTCAAGCTGCGCCTCGAGGGCAATAAGCTGGGCCAGCGGGCGCACTACGAGTGCCCCGAGGGCTTCCGGCTCGACGGCGCCTGGAACGCCACCTGCCTGGCCTCCGGCAATTGGTCATCGCCGACGCCGACCTGCCATGCCATTCAGTGTCCACGTCTGGAGCTGGACGACCCGCACCTCAGCCTGATCGAGCTGAACACCTCGGCATGGGGGCGGGCGGTGTTCAAATGCCAGTGGGGCTTCAAGCTGACCGGACCGGCGCAGCTGGACTGTGAGCCGTCGGGCGTCTGGAGTGGCCCCGTTCCGCGTTGCAAAG
Seq A exon
TCATTCAGTGCGTGATGCCAGTGGCGCCGCTCAACGGGCGCATCGGGGGCACCAGCCTGAGCCAGAGGCGCCTCACCGTGGGCGCCCTGGTCACGTTTAGCTGCAACGACGGGCACAGCCTGGTGGGCGAGTCGAGCATCATCTGCACGGAGAACGGACAGTGGTCGCACTCGCCGCCATTTT
Seq C2 exon
GCAAATCGCAGTGCCCCTATCCCGGCGATCCGCCCAACGGGCTGATAGCGCCGCTCAAGTTCAACTACGACGCCGGAGACTACCTGAGCGTCCAGTGCCGGCCCGGATTTGTCCAGAGTTACGAGGGTCCACCCGAGCGGCCCAAATGCCAGCCGGATGGCCGGTGGTCCGGTCCGATGCCGAAGTGCAAGAGCTACGAGGAGGTGTAACCTCCAGGACCACCAGAGATTGAAGCCAAGGGCCAAGGATTCGCCGCCAAGTCAGCATTACGGGTCCTCCATCTGAGCGGATGCTGTAATTCCGAATGCAGATCGAAACCGAGTGATATTTAGATTAACTTAGTGAGAGGTATCAAAATTAATAGATATTTTATCAGATAGGTTCAATTCAAATCATTGTCTTTCTGTGGCCCACGAATCTTTCAAGAACTCTCCTTTTGAAACTATGTATGTATGTACTCTAAACAGATCAAGTTGATCTTGCACACTCTACAGATATTT
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0010114-'8-10,'8-9,9-10
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (Ref)
No structure available
Features
Disorder rate (Iupred):
C1=0.000 A=0.000 C2=0.111
Domain overlap (PFAM):
C1:
PF0767911=I-set=PD(51.3=23.8),PF0008415=Sushi=WD(100=45.1),PF0008415=Sushi=WD(100=23.8)
A:
PF0008415=Sushi=WD(100=95.2)
C2:
PF0008415=Sushi=PD(0.1=0.0),PF0008415=Sushi=WD(100=84.3)
Main Inclusion Isoform:
FBpp0087688
Main Skipping Isoform:
NA
Other Inclusion Isoforms:
FBpp0087687, FBpp0087689, FBpp0100157
Other Skipping Isoforms:
NA
Associated events
Conservation
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
ATGCCATTCAGTGTCCACGTC
R:
TCGTAGTTGAACTTGAGCGGC
Band lengths:
250-433
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)