HsaEX6024519 @ hg38
Exon Skipping
Gene
ENSG00000108984 | MAP2K6
Description
mitogen-activated protein kinase kinase 6 [Source:HGNC Symbol;Acc:HGNC:6846]
Coordinates
chr17:69414698-69516903:+
Coord C1 exon
chr17:69414698-69415000
Coord A exon
chr17:69505780-69505846
Coord C2 exon
chr17:69516855-69516903
Length
67 bp
Sequences
Splice sites
3' ss Seq
CCTTTTGTCTTTCCCCATAGGCA
3' ss Score
13.59
5' ss Seq
CACGTAAGT
5' ss Score
10.16
Exon sequences
Seq C1 exon
GTTCCAAGTTTGGAGCTTTTAGCTGCCAGCCCTGGCCCATCATGTAGCTGCAGCACAGCCTTCCCTAACGTTGCAACTGGGGGAAAAATCACTTTCCAGTCTGTTTTGCAAGGTGTGCATTTCCATCTTGATTCCCTGAAAGTCCATCTGCTGCATCGGTCAAGAGAAACTCCACTTGCATGAAGATTGCACGCCTGCAGCTTGCATCTTTGTTGCAAAACTAGCTACAGAAGAGAAGCAAGGCAAAGTCTTTTGTGCTCCCCTCCCCCATCAAAGGAAAGGGGAAAATGTCTCAGTCGAAAG
Seq A exon
GCAAGAAGCGAAACCCTGGCCTTAAAATTCCAAAAGAAGCATTTGAACAACCTCAGACCAGTTCCAC
Seq C2 exon
ACCACCTCGAGATTTAGACTCCAAGGCTTGCATTTCTATTGGAAATCAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSG00000108984-'0-17,'0-15,11-17
Average complexity
C1
Mappability confidence:
100%=100=100%
Protein Impact
ORF disruption upon sequence exclusion
No structure available
Features
Disorder rate (Iupred):
C1=1.000 A=0.986 C2=0.682
Domain overlap (PFAM):
C1:
NO
A:
NO
C2:
NO
Main Skipping Isoform:
NA
Other Skipping Isoforms:
NA
Associated events
Other assemblies
Conservation
Chicken
(galGal3)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
ACTTGCATGAAGATTGCACGC
R:
AGAAATGCAAGCCTTGGAGTCT
Band lengths:
167-234
Functional annotations
There are 1 annotated functions for this event
PMID: 26538579
Encodes an experimentally validated Eukaryotic Linear Motif (ELM). Method: bimolecular fluorescence complementation, filter binding. ELM ID: ELMI003289; ELM sequence: KKRNPGLKI; Overlap: FULL
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Autistic and control brains