DmeEX0004374 @ dm6
Exon Skipping
Gene
FBgn0266084 | Fhos
Description
The gene Formin homology 2 domain containing is referred to in FlyBase by the symbol DmelFhos (CG42610, FBgn0266084). It is a protein_coding_gene from Dmel. It has 10 annotated transcripts and 10 polypeptides (8 unique). Gene sequence location is 3L:8753619..8798719. Its molecular function is described by: actin filament binding. It is involved in the biological process described with 12 unique terms, many of which group under: anatomical structure morphogenesis; epithelium development; multicellular organismal process; positive regulation of cellular component movement; programmed cell death involved in cell development. 43 alleles are reported. The phenotypes of these alleles manifest in: intracellular non-membrane-bounded organelle; multicellular structure; intracellular organelle; cytoskeleton; intracellular. The phenotypic classes of alleles include: increased mortality during development; stress response defective; phenotype; fertile.
Coordinates
chr3L:8788939-8790508:+
Coord C1 exon
chr3L:8788939-8789305
Coord A exon
chr3L:8789371-8789517
Coord C2 exon
chr3L:8790170-8790508
Length
147 bp
Sequences
Splice sites
3' ss Seq
TGCATTTGATACACCCTAAGGTC
3' ss Score
3.03
5' ss Seq
AAGGTTCGT
5' ss Score
8.44
Exon sequences
Seq C1 exon
ATCTTCTAGTGTCGATCAGGATGTAAAGAAGTCTGAGCCCAAGAAGTCGGAAAATGAACTTCACTGGGAGGAACTGGTTAGGAATATGACAAGGCCCCTAAATCTTTGCGATCTGGACTTTACGGATCTGAGGGATGATGACGAGAAGGATGTGCTGGCCCCTCGAAGTTTGGGTGCCGGTATACCCCCGCCGCCTCCCCCGCTGGGTGGAGCCATTGCCCCACCGCCAATGATGCCTCCAAGCTTGGCACCACCACCCATGTACGGATATGGCGGTAGTCTAACCAATAGTGTCAATTCGTTAAATGGTTCTATAAATGGTGAACTGGTCAATGGTAATAACACCATCAAAAAGAACAAGAAAACG
Seq A exon
GTCAAGCTCTTCTGGAAGGAAGTGCGCGAGGACATGATACCGCAGGTGGTGGGCAAGACCATATGGGATGAGCTGCCCGATGCCAACGTGGACACACAGAAGCTCGAACATCTCTTTGAGTCCCGGGCCAAAGACTTGATGACCAAG
Seq C2 exon
AAACAACAAGAGCTGAACAAGAGCAAAGAGATCATCGTGCTTGATCACAAGCGCTCCAATGCCATCAATATTGCGATCACTAAGCTGCCTCCTCCGAGGGCCATTAAGACGGCCATCCTCAAAATGGATGCCACTGTGGTCACACGGGAGGGAATCGACAAGCTACTCAATATGCTGCCCACTGATGAGGAGCGTGGCAAGATCCAGGAGGCCCAGTTATCCAACCCAGAGTTGCCCCTGGGCAGCGCCGAGCAGTTCCTTTTGACCCTGGCCTCCATTTCGGAGCTGGAAGCTCGCCTGAAATTGTGGGCTTTCCGTCTGGACTTTGACAACAGTGAG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0266084-'23-20,'23-18,24-20
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (Ref)
No structure available
Features
Disorder rate (Iupred):
C1=0.772 A=0.267 C2=0.098
Domain overlap (PFAM):
C1:
PF0218118=FH2=PU(2.7=8.1)
A:
PF0218118=FH2=FE(13.1=100)
C2:
PF0218118=FH2=FE(30.5=100)
Main Inclusion Isoform:
FBpp0306020
Main Skipping Isoform:
NA
Other Inclusion Isoforms:
FBpp0291295, FBpp0291296, FBpp0291739, FBpp0291740, FBpp0297585, FBpp0297586, FBpp0297587, FBpp0306021
Other Skipping Isoforms:
NA
Associated events
Conservation
Primers PCR
Suggestions for RT-PCR validation
F:
CACCCATGTACGGATATGGCG
R:
GTGACCACAGTGGCATCCATT
Band lengths:
256-403
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)